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76 Gerig, GuidoCorrespondence evaluation in local shape analysis and structural subdivisionRegional volumetric and local shape analysis has become of increasing interest to the neuroimaging community due to the potential to locate morphological changes. In this paper we compare three common correspondence methods applied to two studies of hippocampal shape in schizophrenia: correspondence...2007-01-01
77 Gerig, GuidoGroup mean differences of voxel and surface objects via nonlinear averagingBuilding of atlases representing average and variability of a population of images or of segmented objects is a key topic in application areas like brain mapping, deformable object segmentation and object classification. Recent developments in image averaging, i.e. constructing an image which is cen...2006-01-01
78 Gerig, GuidoClosed and open source neuroimage analysis tools and libraries at UNCThe emergence of open-source libraries and development tools in the last decade has changed the process of academic software development in many ways. In medical image processing and visualization this change is especially evident, also because open source projects are actively furthered by grant fu...2006-01-01
79 Gerig, GuidoModeling 4D changes in pathological anatomy using domain adaptation: analysis of TBI imaging using a tumor databaseAnalysis of 4D medical images presenting pathology (i.e., lesions) is significantly challenging due to the presence of complex changes over time. Image analysis methods for 4D images with lesions need to account for changes in brain structures due to deformation, as well as the formation and deletio...2013-01-01
80 Gerig, Guido3D tensor normalization for improved accuracy in DTI tensor registration methodsThis paper presents a method for normalization of diffusion tensor images (DTI) to a xed DTI template, a pre-processing step to improve the performance of full tensor based registration methods. The proposed method maps the individual tensors of the subject image in to the template space based on ma...2012-01-01
81 Gerig, GuidoTopology preserving atlas construction from shape data without correspondence using sparse parametersStatistical analysis of shapes, performed by constructing an atlas composed of an average model of shapes within a population and associated deformation maps, is a fundamental aspect of medical imaging studies. Usual methods for constructing a shape atlas require point correspondences across subject...2012-01-01
82 Gerig, GuidoTumor-induced structural radiometric asymmetry in brain imagesThis paper presents a general framework for analyzing structural and radiometric asymmetry in brain images. In a healthy brain, the left and right hemispheres are largely symmetric across the mid-sagittal plane. Brain tumors may belong to one or both of the following categories: mass-effect, in whic...2001-01-01
83 Gerig, GuidoMultiscale medial shape-based analysis of image objectsMedial representation of a three-dimensional (3-D) object or an ensemble of 3-D objects involves capturing the object interior as a locus of medial atoms, each atom being two vectors of equal length joined at the tail at the medial point. Medial representation has a variety of beneficial properties,...2003-01-01
84 Gerig, GuidoAnalysis of longitudinal shape variability via subject specific growth modelingStatistical analysis of longitudinal imaging data is crucial for understanding normal anatomical development as well as disease progression. This fundamental task is challenging due to the difficulty in modeling longitudinal changes, such as growth, and comparing changes across different populations...2012-01-01
85 Gerig, GuidoMixed-effects shape models for estimating longitudinal changes in anatomy2012-01-01
86 Taylor, MarkUnderstanding the community based participatory research (CBPR) approach: case study in GhanaIn 2003, the University of Utah, in cooperation with Kwame Nkrumah University of Science and Technology (KNUST), Komfo Anokye Teaching Hospital (KATH), the Atwima Nwabiagya District Assembly and Barekuma community leaders, formed what is known as the Barekuma Collaborative Community Development Proj...2011-12-01
87 Gerig, GuidoStructural integrity of the uncinate fasciculus in geriatric depression: relationship with age of onsetBackground: The uncinate fasciculus connects limbic structures, such as the hippocampus and amygdala, with frontal regions. This study utilized diffusion tensor imaging to examine the structural integrity of the uncinate fasciculus in late-life depression. Method: 18 elderly depressed and 19 elderly...2007-01-01
88 Gerig, GuidoBrain maturation of newborns and infantsRecently, imaging studies of early human development have received more attention, as improved modeling methods might lead to a clearer understanding of the origin, timing, and nature of differences in neurodevelopmental disorders. Non-invasivemagnetic resonance imaging (MRI) can provide three-dimen...2011-01-01
89 Gerig, GuidoEstimation of smooth growth trajectories with controlled acceleration from time series shape dataLongitudinal shape analysis often relies on the estimation of a realistic continuous growth scenario from data sparsely distributed in time. In this paper, we propose a new type of growth model para-meterized by acceleration, whereas standard methods typically control the velocity. This mimics the b...2011-01-01
90 Gerig, GuidoPrenatal mild ventriculomegaly predicts abnormal development of the neonatal brainBackground: Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargeme...2008-01-01
91 Gerig, GuidoTemporal and spatial development of axonal maturation and myelination of white matter in the developing brainBACKGROUND AND PURPOSE-Diffusion tensor imaging (DTI) has been widely used to investigate the development of white matter (WM). However, information about this development in healthy children younger than 2 years of age is lacking, and most previous studies have only measured fractional anisotropy (...2009-01-01
92 Gerig, GuidoDiffusion tensor imaging: application to the study of the developing brainObjective: To provide an overview of diffusion tensor imaging (DTI) and its application to the study of white matter in the developing brain, in both healthy and clinical samples. Method: The development of DTI and its application to brain imaging of white matter tracts is discussed. 48 studies usi...2007-01-01
93 Macleod, Robert S.Sensitivity of epicardial electrical markers to acute ischemia detectionIntroduction: We hypothesize that electrocardiographic measurements from the intramyocardial space contain more sensitive markers of ischemia than those detectable on the epicardium. The goal of this study was to evaluate different electrical markers for their potential to detect the earliest phases...2014-01-01
94 Meyer, Miriah DawnDesign activity framework for visualization designAn important aspect in visualization design is the connection between what a designer does and the decisions the designer makes. Existing design process models, however, do not explicitly link back to models for visualization design decisions. We bridge this gap by introducing the design activity fr...2014-01-01
95 Gerig, GuidoModeling longitudinal MRI changes in populations using a localized, information-theoretic measure of contrastLongitudinal MR imaging during early brain development provides important information about growth patterns and the development of neurological disorders. We propose a new framework for studying brain growth patterns within and across populations based on MRI contrast changes, measured at each time ...2013-01-01
96 Gerig, GuidoSpatiotemporal modeling of distribution-valued data applied to DTI tract evolution in infant neurodevelopmentThis paper proposes a novel method that extends spatiotemporal growth modeling to distribution-valued data. The method relaxes assumptions on the underlying noise models by considering the data to be represented by the complete probability distributions rather than a representative, single-valued su...2013-01-01
97 Solomon, Douglas KipEvaluating the use of strontium isotopes in tree rings to record the isotopic signal of dust deposited on the Wasatch MountainsDust cycling from the Great Basin to the Rocky Mountains is an important component of ecological and hydrological processes. We investigated the use of strontium (Sr) concentrations and isotope ratios (87Sr/86Sr) in tree rings as a proxy for dust deposition. We report Sr concentrations and isotope r...2014-01-01
98 Gerig, GuidoAnalyzing imaging biomarkers for traumatic brain injury using 4D modeling of longitudinal MRIQuantitative imaging biomarkers are important for assessment of impact, recovery and treatment efficacy in patients with traumatic brain injury (TBI). To our knowledge, the identification of such biomarkers characterizing disease progress and recovery has been insufficiently explored in TBI due to d...2013-01-01
99 Gerig, GuidoBuilding spatiotemporal anatomical models using joint 4-D segmentation, registration, and subject-specific atlas estimationLongitudinal analysis of anatomical changes is a vital component in many personalized-medicine applications for predicting disease onset, determining growth/atrophy patterns, evaluating disease progression, and monitoring recovery. Estimating anatomical changes in longitudinal studies, especially th...2012-01-01
100 Gerig, GuidoLongitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopmentWe present a new framework for spatiotemporal analysis of parameterized functions attributed by properties of 4D longitudinal image data. Our driving application is the measurement of temporal change in white matter diffusivity of fiber tracts. A smooth temporal modeling of change from a discrete-ti...2012-01-01
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