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51 Peterson, MikalSomatic chromosome pairing in interspecific drosophila hybrid and hybried rescue crossesHomologous chromosomes of somatic tissue pair together in Drosophila. One current model proposes that somatic pairing starts in an undirected manner; when sites on the chromosome, called "buttons", come into contact and pair. Then, after this initial pairing, the rest of the chromosome then synapses...2022
52 Rohaj, AarushiApoptosis efficiency of the transfected elephant and human P35 vectors in P53 varying leiomyosarcoma cellsComparative Oncology is an approach that integrates and connects commonly occurring cancers seen in animals, into studies focused on cancer biology, prevention, and treatment in humans. Studies show that natural mechanisms can suppress cancer 1,000 times more adequately in certain animals than in hu...2021
53 Watson, AndrePatterns of parasitism in a common Utah RodentMale-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi...2022
54 Domagala, DrueSynthesis of protacs to inhibit toll-like receptorsThe immune system is the body's defense against pathogens. Since it has to be able to withstand the fast-evolving nature of microscopic invaders, the immune system has a variety of mechanisms to recognize and destroy them. One way that pathogens are recognized is through toll-like receptor (TLR) sig...2022
55 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
56 Sperber, Alexander M.A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cellsHeart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I...2022
57 Mercer, MarianneEstablishing a System for Structure-Function analysis of the Novel Role that NUP153 Plays in Nuclear AssemblyIn mitosis, equal partitioning of DNA between daughter cells requires an integrated series of events. At the start of anaphase the chromatin separates and forms two chromatin discs. This chromatin is then targeted by nuclear membrane proteins and membrane to form the nuclear envelope. These membrane...2018
58 Chure, Griffin DanielFLHE influences cellular morphology through control of flagellar assembly in escherichia coliThe bacterial flagellar motor is a complex nanomachine composed of thousands of individual protein subunits. One of these proteins, FlhE, has not been studied in depth and its function is not completely understood. The flhE gene is cotranscribed with flhB and flhA in the flhBAE flagellar operon. In ...Escherichia coli; Flagella (Microbiology)2013-05
59 Blair, Coral DeanSnakes as a possible winter reservoir for Western equine encephalitis virusviruses; equine; snakes1964
60 Fackler, Anderson N.Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegansNeurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a...2018
61 Ong, ElaineIdentifying Natural Genetic Modifiers of Apoptosis and Retinal DegenerationApoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ...2018
62 Johnson, KariAnne RencherIdentification of PASK substrates and/or interacting proteinsPAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live...Biology2012-05
63 Weaver, BradleyHypoxia and the mesenchymal transition in gliomaRecent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum...Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition2014-04
64 Au, AlexanderImpact of population density of left atrial remodeling in patients with atrial fibrillationAtrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow...Atrial fibrillation Treatment2012-05
65 Little, Nancy AnnCharacterizing and mapping l(3)7E103 a gene required for Drosophila dorsal closureDorsal closure in the fruit fly Drosophila melanogaster is a complex morphogenetic process dependent upon three embryonic tissues: the lateral epidermis, leading edge epidermis, and amnioserosa. Additionally, the Jun N-terminal Kinase (JNK) and Decapentaplegic (Dpp) signaling cascades are required f...Drosophila melanogaster - Genetics; Drosophila melanogaster - Embryology2013-05
66 Barbeau, WilliamCharacterization of a New Ribosome Associated Quality Control PathwayProteins are life's double edged sword. Proteins are essential macromolecules of life, and the tasks that some proteins accomplish are quite marvelous. At the same time, if proteins misfold they have the potential to kill the cell that harbors them. It is becoming increasingly clear that proteins ha...Ribosomes - Research2016-12
67 Neville, RoselynConstitutively activated AKT is not sufficient to keep cells alive following epithelial cell extrusionThe PI3 kinase (PI3K)/AKT signaling pathway regulates many fundamental behaviors of the cell. If any of the key members of this pathway are deregulated, it can lead to malignant changes in the cell. AKT enhances the survival of cells by inhibiting pro-apoptotic processes, and promoting pathways for ...PI3K/AKT - Chemistry; Cancer metastasis2014-05
68 Tazehabadi, TaraBioinformatics to detect functional interactions important for the DNA repair enzyme mutyhDNA is the blueprint of all biological life as it provides the means necessary for sharing of genetic information. DNA is formed and stabilized by interactions between four unique bases, Adenine (A), Cytosine (C), Guanine (G), and Thymine (T) which come together in predetermined patterns to create a...2022
69 Thomas, NathanielThe HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of...2022
70 Mallender, ZacharyAssay of the dreem device on sleep metrics and an exploration of sleep staging in chronic short sleepers during time in bed extensionDespite clear and plentiful research that sleeping less than seven hours per night has a wide array of health consequences, a large portion of American adults report sleeping less than seven hours per night and thus receive chronic insufficient sleep. Many studies exploring the consequences of insuf...2022
71 Hahm, SuhyunStressors of varying properties induce differences in the modulation of behavior and biologyStress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor...2022
72 Smith, SarahEffects of Mitochondrial Mobility on Astrocyte FunctionWithin the brain, astrocytes provide support and influence the excitability of neurons by regulating the extracellular levels of potassium (K+) and glutamate. These glial cells play a vital role in neural homeostasis by regulating the concentration of neurotransmitters at the synapse, therefore modu...2018
73 Effects of Acute Hypoxia and High pCO2 on Total Protein Content and Metabolic Enzyme Activity in Rockfishes (Sebastes SPP.)Climate change is altering ocean chemistry and wind-driven upwelling regimes. In the California Current System (CCS), these changes are exposing nearshore fishes to increasing levels of high pCO2 and hypoxia. These stressors co-occur during upwelling events, lasting hours to days, and both have the ...2019
74 Lebrecht, MarandaEffects of ventilatory regimens on the prevalence of a common gastrointestinal disease in neonatesNecrotizing Enterocolitis, or NEC, is a common intestinal disease of preterm neonates. It is believed that bacterial colonization increases the risk of NEC. This study examines whether the type of ventilation of the neonate, either mechanical ventilation (MV) or non-invasive support (NIS), and the ...Enterocolitis, Neonatal necrotizing - Research; Newborn infants - Diseases; Sheep as laboratory animals - Research; Necrotizing enterocolitis; Lymphocytes2016-05
75 Muehlman, JayantiEffects of Wind-Generated Underwater Noise on Southern right Whale Group DynamicThe goal of this study was to investigate whether underwater noise affects the grouping behavior of southern right-whale (Eubalaena australis) mother-calf pairs at Península Valdés, Argentina. This area is a major calving ground for the population that occupies the western South Atlantic. Two larg...2020
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