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CreatorTitleDescriptionSubjectDate
51 Horch, Kenneth W.Intrafascicular electrodes for nerve stimulationWe have designed a new type of intrafascicular, implanted electrode for stimulating peripheral nerves to elicit muscle contraction. The electrode requires low current to stimulate the nerve fibers, provides a fine control of muscular force, and causes little or no tissue reaction. it is of potential...Intrafascicular electrodes; Peripheral nerve; Neural recordings1988
52 Horch, Kenneth W.Intraspinal microstimulation using cylindrical multielectrodesA cylindrical multielectrode system specifically designed for intraspinal microstimulation was mechanically and electrically evaluated in the ventral horn of the feline lumbo-sacral spinal cord. Electrode insertions proved to be straight as evaluated from radiographs. Impedances were measured in s...Cylindrical multielectrode; Microstimulation; Neural prosthesis; Current distance constants; Electrode array; Spinal cord stimulation2006-02
53 Christensen, Douglas A.Introduction to biomedical engineering: biomechanics and bioelectricity - part IIntended as an introduction to the field of biomedical engineering, this book covers the topics of biomechanics (Part I) and bioelectricity (Part II). Each chapter emphasizes a fundamental principle or law, such as Darcy's Law, Poiseuille's Law, Hooke's Law, Starling's law, levers and work in the a...Biological membranes; Poiseuille's law; Hooke's law; Starling's law of the heart; Matlab2009
54 Christensen, Douglas A.Introduction to biomedical engineering: biomechanics and bioelectricity - part IIIntended as an introduction to the field of biomedical engineering, this book covers the topics of biomechanics (Part I) and bioelectricity (Part II). Each chapter emphasizes a fundamental principle or law, such as Darcy's Law, Poiseuille's Law, Hooke's Law, Starling's Law, levers and work in the...Bioelectricity; Kirchhoff's voltage law; Kirchhoff's current law; Coulomb's law; Thevenin equivalent circuits; Nernst potential; Matlab2009
55 Christensen, Douglas A.Laser diode coherence length variation with drive current: a tool for dispersion measurementsA visible light (670nm) laser diode was used as a variable coherence length source to measure dispersion characteristics in single-mode fibers. The diode's spectral width, measured against increasing drive current, was found to change from about 16 nanometers to less than 0.2 nanometer. The corresp...Laser diode; Fiber interferometry1992
56 Horch, Kenneth W.Mechanical testing of metallic and polymeric intrafascicular electrodesWe are exploring alternatives to Pt/Ir wire for constructing ultra-flexible neural intrafascicular electrodes suitable for chronic implantation. In this study we measured the flexural properties of several kinds of fine metal wires and conducting polymer fibers. The fibers were made either of in...Intrafascicular electrodes; Polymer fibers1994
57 Horch, Kenneth W.Microfabricated cylindrical multielectrodes for neural stimulationThe effects of spinal cord injuries are likely to be ameliorated with the help of functional electrical stimulation of the spinal cord, a technique that may benefit from a new style of electrode: the cylindrical multielectrode. This paper describes the specifications for, fabrication techniques for...Cylindrical multielectrode; Depth electrodes; Impedance testing; Microelectromechanical systems (MEMS); Microstimulation; Impedance testing; Neural prosthesis2006-02
58 Jenson, Justin Michael; Bock, Susan C.Mitigating spinal cord injuryHow would your life change if you became one of the 15,000 Americans to suffer a spinal cord injury this year? Trauma to the spinal cord causes immediate loss of function below the level of the injury. Then, in the hours and days after the accident, the body's secondary injury response may extend ...Trapeze Interactive Poster2010-03-15
59 Normann, Richard A.; Horch, Kenneth W.; Cha, KichulMobility performance with a pixelized vision systemA visual prosthesis, based on electrical stimulation of the visual cortex, has been suggested as a means for partially restoring functional vision in the blind. The prosthesis would create a pixelized visual sense consisting of punctate spots of light (phosphenes). The present study investigated the...Visual Prosthesis; Mobility; Phosphene Simulator1992
60 Christensen, Douglas A.Modeling sources in the FDTD formulation and their use in quantifying source and boundary condition errorsThe modeling of voltage and current sources as either added or replaced sources in FDTD simulations is described and their differences discussed in terms of a transmission line analogy. An infinitesimal current element (ICE) is used to illustrate the validation of added source modeling and to study...Finite-difference time-domain method; Infinitesimal current element1995-04
61 Christensen, Douglas A.Multiple sensor optical thermometry system for application in clinical hyperthermiaThe thermometry system described is based upon the temperature dependence of the band edge absorption of infrared light in GaAs crystal. The design of the thermometry was completed, and the system was subjected to an extensive evaluation, including testing with tissue phantoms and microwave applic...Thermometry; Hyperthermia applicator; Phantom tests1984-01
62 Horch, Kenneth W.Muscle recruitment through electrical stimulation of the lumbo-sacral spinal cordThe goal of this study was to determine the feasibility of producing graded muscle contraction in individual muscles or muscle groups by electrically stimulating motor neurons in the lumbo-sacral spinal cord. Recruitment curves were obtained for quadriceps, tibialis anterior and triceps surae/pl...Functional neuromuscular stimulation (FNS); Motor pools, Muscle recruitment, Spinal cord stimulation2000
63 Horch, Kenneth W.Muscle recruitment with intrafascicular electrodesWe have studied muscle recruitment with Tefloninsulated, 25 pm diameter, Pt-Ir intrafasicular electrodes implanted in nerves innervating the gastrocnemius and soleus muscles of cats. The purpose of this study was to measure the performance of these bipolar electrodes, which had been designed to...Functional neuromuscular stimulation (FNS); Intrafascicular electrode1991
64 Normann, Richard A.; Maynard, Edwin M.Neural interface for a cortical vision prosthesisThe development of a cortically based vision prosthesis has been hampered by a lack of basic experiments on phosphene psychophysics. This basic research has been hampered by the lack of a means to safely stimulate large numbers of cortical neurons. Recently, a number of laboratories have developed a...Neuroprosthetics; Artificial Vision; Electrode Arrays; Multielectrode Recordings; Biocompatibility1999
65 Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul RichardNeural signal for skin indentation depth. I. Changing indentationsPsychophysical tests on human subjects showed that judgments of skin indentation depth made when the fingertip was indented at rates from 0.2 to 16 mm/set were quite insensitive to changes in indentation velocity. Similar results were obtained on the forearm at indentation velocities of 0.4 to 16...Skin; Indentation; Nerve impulses1983
66 Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul RichardNeural signal for skin indentation depth. II. Steady indentationsThe glabrous skin of the monkey's hand was stimulated with a waveform that indented the skin at a rate of 0.4 mm/set, held the skin steadily or nearly steadily indented for 12 set or longer, and then retracted back to the starting position. Recordings were made of activity in single afferent fibe...Skin; Indentation; Nerve impulses1983
67 Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul RichardNeural signal for the intensity of a tactile stimulusThe effect of indenting the skin at different rates on the perceived intensity of the stimulus was studied by indenting the skin of the fingertip with two triangular waveforms, given as a pair. The subjects were asked to judge which member of the pair was more intense. Perceived intensity was foun...Skin; Indentation; Nerve impulses1984
68 Horch, Kenneth W.; Normann, Richard A.Noble metal penetrating cortical stimulating electrode array: preliminary resultsElectrical stimulation of the visual cortex causes subjects to see spots of light (phosphenes) in their visual fields. We have developed arrays of penetrating electrodes which may from the basis of a visual prosthesis centered around electrical stimulation of the visual cortex. These arrays have bee...Visual prosthesis1988
69 Horch, Kenneth W.On the number and nature of regenerating myelinated axons after lesions of cutaneous nerves in the cat1. Electrophysiological and anatomical techniques were used to investigate normal and regenerating sural and posterior femoral cutaneous nerve fibres in the cat. 2. One and a half years after transection of these nerves it was found that the regenerating neurones supported multiple sprouts in the...Nerve fibres; Transection; Nerve injury1981
70 Horch, Kenneth W.Ontogeny of diving and feeding behavior in juvenile seaturtles: Leatherback Seaturtles (Dermochelys coriacea L) and Green Seaturtles (Chelonia mydas L) in the Florida CurrentWe compared activity, diving behavior and response to prey by Dermochelys coriacea and Chelonia mydas during their first 8-10 weeks of development.We reared juveniles in the laboratory and, at two-week intervals, released them in the ocean for a brief trial. Each turtle towed a device used to measur...Hatchlings; Posthatchling; Habitats2004
71 Christensen, Douglas A.; Herron, James N.Optical immunoassay systems based upon evanescent wave interactionsImmunoassays based upon evanescent wave interactions are finding increased biosensing application. In these devices, the evanescent tail associated with total internal reflection of an incident beam at the substrate/solution interface provides sensitivity for surface-bound proteins over bulk molec...Diagnostics; Evanescence; Planar waveguides; Human chorionic gonadotropin (hCG)1996
72 Gesteland, Raymond F.; Atkins, John F.; Baranov, Pavel V.P-site tRNA is a crucial initiator of ribosomal frameshiftingThe expression of some genes requires a high proportion of ribosomes to shift at a specific site into one of the two alternative frames. This utilized frameshifting provides a unique tool for studying reading frame control. Peptidyl-tRNA slippage has been invoked to explain many cases of programmed ...Translation; Recoding; Kinetic Model; Frameshifting; Ribosome2004
73 Gesteland, Raymond F.Pattern of protein synthesis in monkey cells infected by simian virus 40After infection of several permanent monkey cell lines by simian virus 40 (SV40), four additional protein bands can be detected by simple sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell extracts. These bands appear only after the onset of viral deoxyribonucleic acid (DNA) syn...Monkeys; Simian virus 40; Peptides; DNA, Viral/biosynthesis1972
74 Horch, Kenneth W.Perspectives on new electrode technology for stimulating peripheral nerves with implantable motor prosthesesAbstract-The limits of present electrode technology are being reached in current motor prostheses for restoring functional movement in paralyzed people. Improved devices require electrodes and stimulation methods that will activate muscles selectively and independently with less implanted hardwa...Paralysis; Prostheses; Electrodes1995
75 Baehr, Wolfgang; Prestwich, Glenn D.Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding proteinBovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate...Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry2004
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