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Creator | Title | Description | Subject | Date |
| 501 |
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Capecchi, Mario R. | How close are we to implementing gene targeting in animals other than the mouse? | Describes several significant contributions that bring us much closer to extending ‘‘gene targeting'' to mammalian species other than the mouse. Gene targeting now provides the means for creating new strains of mice with mutations in virtually any gene. First, the desired mutation is introduced ... | Cattle; Mutagenesis; Mice; Humans; Ethics, Medical | 2000-02-01 |
| 502 |
 |
Rogers, Alan R. | How much can fossils tell us about regional continuity? | Presents a study on the genetic contribution of earlier populations to later populations within regions called regional continuity. Testing for regional continuity with multiple characters; Replacement of archaic population by a population of modern humans. | Human genetics; Fossils; Regional continuity | 2006-06-05 |
| 503 |
 |
Capecchi, Mario R. | Hox genes and mammalian development | We have examined the interactions of Hox genes in forming a cervical vertebrae, hindbrain, and limbs. In each case, it is apparent that individual Hox genes are performing individual functions but that more profound roles are apparent when they act in combination with others Hox genes. The observed ... | Drosophila; Gene Expression Regulation, Developmental; Homozygote | 1997 |
| 504 |
 |
Capecchi, Mario R. | Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. | Hox genes encode transcription factors that are used to regionalize the mammalian embryo. Analysis of mice carrying targeted mutations in individual and multiple Hox genes is beginning to reveal a complex network of interactions among these closely related genes which is responsible for directing th... | Abnormalities, Multiple; Gene Targeting; Glossopharyngeal Nerve; Mice, Knockout; Morphogenesis | 1997-12-15 |
| 505 |
 |
Capecchi, Mario R. | Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. | The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches. Hoxa3 mutant homozygotes have defects in the development of all three organs. Roles for the Hoxa3 para... | Animals, Newborn; Calcitonin; Ectoderm; Gene Dosage; Genotype; Mice, Mutant Strains; Phenotype | 1998-03-01 |
| 506 |
 |
Capecchi, Mario R. | Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. | Mice in which all members of the Hox10 or Hox11 paralogous group are disrupted provide evidence that these Hox genes are involved in global patterning of the axial and appendicular skeleton. In the absence of Hox10 function, no lumbar vertebrae are formed. Instead, ribs project from all posterior ve... | Alleles; Animals; Forelimb; Gene Expression Regulation, Developmental; Hindlimb | 2003-07-18 |
| 507 |
 |
Capecchi, Mario R. | Hox11 paralogous genes are essential for metanephric kidney induction | The mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phen... | Metanephric; Six2; Wt1 | 2002-06-01 |
| 508 |
 |
Capecchi, Mario R.; Tvrdik, Petr | Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. | Formation of neuronal circuits in the head requires the coordinated development of neurons within the central nervous system (CNS) and neural crest-derived peripheral target tissues. Hoxb1, which is expressed throughout rhombomere 4 (r4), has been shown to be required for the specification of facial... | Rhombomere 4; Branchiomotor; Cranial Nerve | 2004-07-04 |
| 509 |
 |
Capecchi, Mario R. | Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae | To address the expression and function of Hoxb13, the 5' most Hox gene in the HoxB cluster, we have generated mice with loss-of-function and beta-galactosidase reporter insertion alleles of this gene. Mice homozygous for Hoxb13 loss-of-function mutations show overgrowth in all major structures deriv... | Animals; Axons; Ganglia, Spinal; Mice; Spinal Cord | 2003-04-15 |
| 510 |
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Capecchi, Mario R. | Hoxb8 is required for normal grooming behavior in mice. | Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Add... | Aging; Alleles; Animals, Newborn; Behavior, Animal; Bone and Bones; Disease Models, Animal; Mice, Knockout Nerve Net | 2002-01-03 |
| 511 |
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Capecchi, Mario R. | Hoxc13 mutant mice lack external hair | Hox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibri... | Filiform papillae; Homozygotes; Paralogous | 1998-01-01 |
| 512 |
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Varner, Michael W. | hPL: physiologic and pathophysiologic observations. | Serum human placental lactogen (hPL) levels were studied in 806 women in late pregnancy. The hPL levels were positively correlated with birth weight but were unrelated to maternal age, parity, socioeconomic status, or the sex of the newborn. The hPL levels peaked at 37 weeks' gestation and then decl... | hPL; Pregnancy Complications; Pregnancy, Multiple; Infant, Newborn; Birth Weight | 1979-08 |
| 513 |
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Bernstein, Paul S. | HPLC measurement of ocular carotenoid levels in human donor eyes in the lutein supplementation era. | PURPOSE: A substantial proportion of the population at risk for visual loss from age-related macular degeneration consumes supplements containing high doses of lutein, but clinical studies to date have shown only modest and variable increases in macular carotenoid pigments in response to supplementa... | Chromatography, High Pressure Liquid; Dietary Supplements; Tissue Donors | 2007-02 |
| 514 |
 |
Baehr, Wolfgang | Human interstitial retinoid-binding protein. Gene structure and primary structure | Interstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ... | Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA | 1989-05-15 |
| 515 |
 |
Varner, Michael W. | Human placental lactogen and other placental proteins as indicators of fetal well-being. | The purpose of this article will be to review the role of hPL and the newer hormones as indicators of fetal well-being. | Human Placental Lactogen; Pregnancy Proteins; Indicators of Fetal Well-Being | 1982-12 |
| 516 |
 |
Varner, Michael W. | Human placental lactogen: a predictor of perinatal outcome? | Serial human placental lactogen (hPL) determinations were performed on 806 women with normal and abnormal pregnancies late in the pregnancy. These results were not reported to the clinicians involved. For the study population as a whole, low hPL levels did not effectively predict those adverse perin... | Infant, Newborn; Placental Lactogen; Pregnancy; Prenatal Diagnosis | 1979-08 |
| 517 |
 |
Bernstein, Paul S. | Human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture | PURPOSE. A spontaneously arising, apparently transformed, cell line has been cloned from a primary culture of human retinal pigment epithelial (RPE) cells and has been subcultured more than 200 times. The similarities of these cells to human RPE cells in vivo have been determined. METHODS. The struc... | Cell Line, Transformed; Chromatography, High Pressure Liquid; Phagocytosis | 1995 |
| 518 |
 |
Erickson, J. Alan; Smith, Jeffrey, J.; Bornhorst, Joshua A.; Ashwood, Edward R. | Humananti-mouse antibody protected ELISA for the quantification of squamous cell carcinoma antigen | Squamous cell carcinoma antigen (SCC) was first isolated from squamous cell carcinoma tissue of the uterine cervix and initially reported as TA-4. The antigen has been characterized as a glycoprotein with a molecular weight between 45,000 and 55,000 daltons. Studies suggest that SCC may function as ... | SCC; Squamous Cell Carcinoma Antigen; BSA; PBS; Phosphate Buffered Saline; HAMA; Human Anti-mouse Antibodies; IIR; ImmunoglobulinInhibiting Reagent | 2005-12-09 |
| 519 |
 |
Meadows, Natalie | Hunting for insight: an analysis of hunting behaviors in mice | Behaviors revolving around the acquisition of food resources are complex and crucial processes for many organisms. Hunting is an especially interesting behavior, which involves complex cognitive and social behaviors. In order to study rudimentary hunting behaviors in a controlled setting a model org... | Hunting; Mouse behavior; ADD/ADHD; Autism | 2014-06-24 |
| 520 |
 |
Couldwell, William T. | Hypericin: a potential antiglioma therapy | HYPERICIN, A POLYCYCLIC aromatic dione isolated from plants, is presently being clinically evaluated as an antiviral agent in the treatment of human immunodeficiency virus (HIV) infection. In addition, it is known to be a potent protein kinase C inhibitor. To evaluate its potential as an inhibitor o... | Hypericin; Protein kinase C; Glioma; Brain neoplasm | 1994 |
| 521 |
 |
Nebeker, Jonathan R.; Samore, Matthew H | Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the research on adverse drug events and reports (RADAR) project | OBJECTIVES: We undertook the review of all available cases of hypersensitivity reactions after placement of a drug-eluting stent (DES) and classified potential causes. BACKGROUND: Six months after the approval of the first DES, the Food and Drug Administration (FDA) reported 50 hypersensitivity reac... | Drug Hypersensitivity; Coronary Vessels | 2006 |
| 522 |
 |
Couldwell, William T.; Osborne, Anne G. | Hypertrophic olivary degeneration after surgical removal of cavernous malformations of the brain stem: report of four cases and review of the literature | Background: Hypertrophic olivary degeneration (HOD) is a pathological phenomenon that occurs after injury to the dentato-olivary pathway. Its hallmarks include hypertrophy of the olive with increased T2 signal intensity on magnetic resonance imaging, and often manifests with palatal tremor and osci... | Hypertrophic olivary degeneration; Surgery; Cavernous malformation; Brainstem | 2008 |
| 523 |
 |
Couldwell, William T.; Schmidt, Meic H.; MacDonald, Joel D.; Jensen, Randy L. | Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinus | Stereotactic radiosurgery (SRS) is performed with increasing frequency in the treatment of residual or recurrent pituitary adenomas. Its major associated risk in these cases of residual or recurrent pituitary tumor adjacent to normal functional pituitary gland is radiation exposure to the pituitary,... | Pituitary tumor; Cavernous sinus; Hypopituitarism; Stereotactic radiosurgery; Transsphenoidal surgery; Pituitary transposition | 2003 |
| 524 |
 |
Schmidt, Meic H.; MacDonald, Joel D.; Jensen, Randy L.; Couldwell, William T. | Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinus | Stereotactic radiosurgery (SRS) is performed with increasing frequency in the treatment of residual or recurrent pituitary adenomas. Its major associated risk in these cases of residual or recurrent pituitary tumor adjacent to normal functional pituitary gland is radiation exposure to the pituitary,... | Hypophysial transposition; Hypophysopexy; Pituitary tumors; Stereotactic radiosurgery; Pituitary transposition; Hypopituitarism | 2003 |
| 525 |
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Warner, Homer R. | IAIMS Implementation and Administration at the University of Utah | Biomedical Informatics | | 1986 |
