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Creator | Title | Description | Subject | Date |
26 |
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Gerig, Guido | Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain | Background: Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargeme... | | 2008-01-01 |
27 |
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Gerig, Guido | Assessment of reliability of multi-site neuroimaging via traveling phantom study | This paper describes a framework for quantitative analysis of neuroimaging data of traveling human phantoms used for cross-site validation. We focus on the analysis of magnetic resonance image data including intra- and intersite comparison. Locations and magnitude of geometric deformation is studied... | | 2008-01-01 |
28 |
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Gerig, Guido | A structural MRI study of human brain development from birth to two years | Brain development in the first 2 years after birth is extremely dynamic and likely plays an important role in neurodevelopmental disorders, including autism and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain development in healthy subjects from... | | 2008-01-01 |
29 |
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Gerig, Guido | Minimum description length with local geometry | Establishing optimal correspondence across object populations is essential to statistical shape analysis. Minimizing the description length (MDL) is a popular method for finding correspondence. In this work, we extend the MDL method by incorporating various local curvature metrics. Using local curva... | | 2008-01-01 |
30 |
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Gerig, Guido | Discordance of prenatal and neonatal brain development in twins | Background: Discordance of birth weight has been observed in twin pairs, though little is known about prenatal and early neonatal discordance of head and brain size, and the role that zygosity and chorionicity play in discordances of early brain development in twins. Aims: To compare prenatal and ne... | | 2009-01-01 |
31 |
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Gerig, Guido | Constrained data decomposition and regression for analyzing healthy aging from fiber tract diffusion properties | It has been shown that brain structures in normal aging undergo significant changes attributed to neurodevelopmental and neurodegeneration processes as a lifelong, dynamic process. Modeling changes in healthy aging will be necessary to explain differences to neurodegenerative patterns observed in m... | | 2009-01-01 |
32 |
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Gerig, Guido | Cortical enhanced tissue segmentation of neonatal brain MR images acquired by a dedicated phased array coil | The acquisition of high quality MR images of neonatal brains is largely hampered by their characteristically small head size and low tissue contrast. As a result, subsequent image processing and analysis, especially for brain tissue segmentation, are often hindered. To overcome this problem, a dedic... | | 2009-01-01 |
33 |
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Gerig, Guido | Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism | To examine brain volumes in substructures associated with the behavioral features of children with FXS compared to children with idiopathic autism and controls. A cross-sectional study of brain substructures was conducted at the first time-point as part of an ongoing longitudinal MRI study of brain ... | | 2009-01-01 |
34 |
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Gerig, Guido | Temporal and spatial development of axonal maturation and myelination of white matter in the developing brain | BACKGROUND AND PURPOSE-Diffusion tensor imaging (DTI) has been widely used to investigate the development of white matter (WM). However, information about this development in healthy children younger than 2 years of age is lacking, and most previous studies have only measured fractional anisotropy (... | | 2009-01-01 |
35 |
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Gerig, Guido | Voxel-wise group analysis of DTI | Diffusion tensor MRI (DTI) is now a widely used modality to investigate the fiber tissues in vivo, especially the white matter in brain. An automatic pipeline is described in this paper to conduct a localized voxel-wise multiple-subject group comparison study of DTI. The pipeline consists of 3 steps... | | 2009-01-01 |
36 |
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Gerig, Guido | Evaluation of DTI property maps as basis of DTI atlas building | Compared to region of interest based DTI analysis, voxel-based analysis gives higher degree of localization and avoids the procedure of manual delineation with the resulting intra and inter-rater variability. One of the major challenges in voxel-wise DTI analysis is to get high quality voxel-level c... | | 2010-01-01 |
37 |
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Gerig, Guido | Quality control of diffusion weighted images | Diffusion Tensor Imaging (DTI) has become an important MRI procedure to investigate the integrity of white matter in brain in vivo. DTI is estimated from a series of acquired Diffusion Weighted Imaging (DWI) volumes. DWI data suffers from inherent low SNR, overall long scanning time of multiple dire... | | 2010-01-01 |
38 |
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Gerig, Guido | Towards analysis of growth trajectory through multi-modal longitudinal MR imaging | The human brain undergoes significant changes in the first few years after birth, but knowledge about this critical period of development is quite limited. Previous neuroimaging studies have been mostly focused on morphometric measures such as volume and shape, although tissue property measures rela... | | 2010-01-01 |
39 |
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Gerig, Guido | Image registration driven by combined probabilistic and geometric descriptors | Deformable image registration in the presence of considerable contrast dierences and large-scale size and shape changes represents a signicant challenge for image registration. A representative driving application is the study of early brain development in neuroimaging, which requires co-registratio... | | 2010-01-01 |
40 |
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Gerig, Guido | Brain volumes in psychotic youth with schizophrenia and mood disorders | Background: We sought to test the hypothesis that deficits in grey matter volume are characteristic of psychotic youth with early-onset schizophrenia-spectrum disorders (EOSS) but not of psychotic youth with early-onset mood disorders (EOMD). Methods: We used magnetic resonance imaging to examine br... | | 2010-01-01 |
41 |
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Gerig, Guido | A new framework for analyzing white matter maturation in early brain development | The trajectory of early brain development is marked by rapid growth presented by volume but also by tissue property changes. Capturing regional characteristics of axonal structuring and myelination via neuroimaging requires analysis of longitudinal image data with multiple modalities. Complementary ... | | 2010-01-01 |
42 |
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Gerig, Guido | Changes of MR and DTI appearance in early human brain development | Understanding myelination in early brain development is of clinical importance, as many neurological disorders have their origin in early cerebral organization and maturation. The goal of this work is to study a large neonate database acquired with standard MR imagery to illuminate effects of early ... | | 2010-01-01 |
43 |
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Gerig, Guido | Multi-object analysis of volume, pose, and shape using statistical discrimination | One goal of statistical shape analysis is the discrimination between two populations of objects. Whereas traditional shape analysis was mostly concerned with single objects, analysis of multi-object complexes presents new challenges related to alignment and pose. In this paper, we present a methodol... | | 2010-01-01 |
44 |
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Gerig, Guido | Spatio-temporal analysis of early brain development | Analysis of human brain development is a crucial step for improved understanding of neurodevelopmental disorders. We focus on normal brain development as is observed in the multimodal longitudinal MRI/DTI data of neonates to two years of age. We present a spatio-temporal analysis framework using Gom... | | 2010-01-01 |
45 |
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Gerig, Guido | Estimation of smooth growth trajectories with controlled acceleration from time series shape data | Longitudinal shape analysis often relies on the estimation of a realistic continuous growth scenario from data sparsely distributed in time. In this paper, we propose a new type of growth model para-meterized by acceleration, whereas standard methods typically control the velocity. This mimics the b... | | 2011-01-01 |
46 |
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Gerig, Guido | Twin-singleton differences in neonatal brain structure | Twin studies suggest that global and regional brain volumes are highly heritable. However, estimates of heritability vary across development. Given that all twin studies are open to the potential criticism of non-generalizability due to differences in intrauterine environment between twins and singl... | | 2011-01-01 |
47 |
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Gerig, Guido | Efficient probabilistic and geometric anatomical mapping using particle mesh approximation on GPUs | Deformable image registration in the presence of considerable contrast differences and large size and shape changes presents significant research challenges. First, it requires a robust registration framework that does not depend on intensity measurements and can handle large nonlinear shape variati... | | 2011-01-01 |
48 |
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Gerig, Guido | Brain maturation of newborns and infants | Recently, imaging studies of early human development have received more attention, as improved modeling methods might lead to a clearer understanding of the origin, timing, and nature of differences in neurodevelopmental disorders. Non-invasivemagnetic resonance imaging (MRI) can provide three-dimen... | | 2011-01-01 |
49 |
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Gerig, Guido | Spatial intensity prior correction for tissue segmentation in the developing human brain | The degree of white matter (WM) myelination is rather inhomogeneous across the brain. As a consequence, white matter appears differently across the cortical lobes in MR images acquired during early postnatal development. At 1 year old specifically, the gray/white matter contrast of MR images in pref... | | 2011-01-01 |
50 |
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Gerig, Guido | Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse | The use of structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in animal models of neurophysiology is of increasing interest to the neuroscience community. In this work, we present our approach to create optimal translational studies that include both animal and human neu... | | 2011-01-01 |