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26 Varner, Michael W.Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis.OBJECTIVE: To measure angiogenin, a potent inducer of neovascularization and interleukin-6, as an indicator of acute inflammation, in second-trimester amniotic fluid of patients with elevated maternal serum hCG. METHODS: In this case-control study, 20 patients with elevated maternal serum hCG (at le...Angiogenesis Inducing Agents; Interleukin-6; Pregnancy Complications; hCG1998-04
27 Varner, Michael W.Serial salivary estriol to detect an increased risk of preterm birth.OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 women with singleton pregnancies was completed at eight United States medical centers. Saliva was coll...Estriol; Preterm Birth; Spontaneous Preterm Labor2000-10
28 Moon, Ann M.; Capecchi, Mario R.Fgf8 is required for outgrowth and patterning of the limbs.The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep...Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm2000-12-26
29 Buchi, Karen F.; Varner, Michael W.Changing prevalence of prenatal substance abuse in Utah.OBJECTIVE: To estimate the current prevalence of prenatal exposure to methamphetamines and other drugs of abuse among infants born in Utah and compare the results with those of a maternal substance abuse prevalence study performed in 1991 in the same geographic area. METHODS: Thirteen well baby nurs...Street Drugs; Prenatal Care; Maternal Exposure; Infant, Newborn2003-06-12
30 Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. JohnRobust estimation of fetal heart rate variability using Doppler ultrasound.This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori...Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms2003-08
31 Florsheim, Paul W.; Ngu, LeDifferential outcomes among adolescent fathers: understanding fatherhood as a transformative processIn response to the rising numbers of mother headed households, there is a great debate about whether to encourage young unwed parents to marry. Policies designed to pursue and/or punish fathers who do not meet their legal and financial responsibilities and to promote marriage, carte blanche, are ref...Parenting; Gender; Matrimony2003-10-18
32 Varner, Michael W.Asthma during pregnancyOBJECTIVE: To determine neonatal and maternal outcomes stratified by asthma severity during pregnancy by using the 1993 National Asthma Education Program Working Group on Asthma and Pregnancy definitions of asthma severity. The primary hypothesis was that moderate or severe asthmatics would have an ...Asthma; Infant, Newborn; Pregnancy Outcomes2004-01
33 Moon, Ann M.; Capecchi, Mario R.Roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the in...Animals; Apoptosis; Forelimb; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice, Mutant Strains; Trans-Activators2004-09
34 Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R.Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...Neuroprogenitor; Embryogenesis2004-11-01
35 Coffin, Cheryl M.; Capecchi, Mario R.Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has...Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors2004-11-01
36 Varner, Michael W.Spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy.OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a large multicenter randomized bacterial vaginosis antibiotic trial (metronidazole ver...Pregnancy; Chlamydia Trachomatis; Sexually Transmitted Diseases2005-03
37 Varner, Michael W.Complications of anesthesia for cesarean delivery.OBJECTIVE: To quantify anesthesia-related complications associated with cesarean delivery in a well-described, prospectively ascertained cohort from multiple university-based hospitals in the United States and to evaluate whether certain factors would identify women at increased risk for a failed re...Cesarean Section; Complications of Anesthesia2005-08
38 Varner, Michael W.Does progesterone treatment influence risk factors for recurrent preterm delivery?OBJECTIVE: To examine how demographic and pregnancy characteristics can affect the risk of recurrent preterm delivery and the how the effectiveness of progesterone treatment for prevention alters these relationships. METHODS: This was a secondary analysis of a randomized trial of 17alpha-hydroxyprog...Preterm Delivery; Progesterone Treatment; Pregnancy; Risk Factors2005-09
39 Varner, Michael W.; Lyon, Joseph L.; Alder, Stephen C.; Ellis Simonsen, Sara M.Effect of grand multiparity on intrapartum and newborn complications in young women.OBJECTIVE: To examine the effect of high parity on complications in young women, aged 18-34 years. METHODS: Seven years of Utah birth certificate data were reviewed (1995-2001). Young nulliparas and primiparas were compared with young grand and great grand multi-paras by using logistic regression. Y...Infant, Newborn; Parity; Pregnancy; Risk Factors; Obstetric Labor Complications2005-09
40 Varner, Michael W.Cerebral vasculopathies masquerading as eclampsia.Obstetricians know that preeclampsia-eclampsia is a syndrome and is a final common pathway for multiple causes. It is also possible that other conditions, not always directly related to pregnancy, can mimic preeclampsia-eclampsia. One such entity is cerebral vasculopathy, an entity characterized b...Cerebrovascular Disorders; Eclampsia; Puerperal Disorders2006-02
41 Varner, Michael W.Risk of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery.OBJECTIVE: To determine whether the risk for uterine rupture is increased in women attempting vaginal birth after multiple cesarean deliveries. METHODS: We conducted a prospective multicenter observational study of women with prior cesarean delivery undergoing trial of labor and elective repeat oper...Cesarean Section, Repeat; Uterine Rupture; Vaginal Birth after Cesarean; Obstetric Labor Complications/surgery2006-07
42 Varner, Michael W.Decision-to-incision times and maternal and infant outcomes.OBJECTIVE: To measure decision-to-incision intervals and related maternal and neonatal outcomes in a cohort of women undergoing emergency cesarean deliveries at multiple university-based hospitals comprising the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units N...Cesarean Section; Fetal Distress; Outcome Assessment; Fetal Distress2006-07
43 Varner, Michael W.Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women.OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate t...Asthma; Body Mass Index; Pregnancy Outcome; Lung Diseases2006-07
44 Varner, Michael W.Trial of labor or repeat cesarean delivery in women with morbid obesity and previous cesarean delivery.OBJECTIVE: Assess effects of body mass index (BMI) on trial of labor after previous cesarean delivery and determine whether morbidly obese women have greater maternal and perinatal morbidity with trial of labor compared with elective repeat cesarean delivery. METHODS: Secondary analysis from a prosp...Pregnancy Outcome; Obesity; Repeat Cesarean Section; Body Mass Index2006-07
45 Wen, Ming; Van Duker, Heather; Olson, Lenora MarySocial contexts of regular smoking in adolescence: towards a multidimensional ecological modelUsing data from the Longitudinal Study of Adolescent Health (Add Health), this study investigates factors at the individual, family, peer, school, neighborhood, and state levels that are important for subsequent adolescent cigarette regular smoking after controlling for the baseline smoking behavio...Adolescent smoking; Social capital; Family; Neighborhood; School; Teenagers; Teenage smoking2006-09-19
46 Varner, Michael W.Blood transfusion and cesarean delivery.OBJECTIVE: To evaluate risks for intraoperative or postoperative packed red blood cell transfusion in women who underwent cesarean delivery. METHODS: This was a 19-university prospective observational study. All primary cesarean deliveries from January 1, 1999, to December 31, 2000, and all repeat c...Blood Transfusion; Postpartum Hemorrhage; Pregnancy Complications; Anemia2006-10
47 Varner, Michael W.Fetal injury associated with cesarean delivery.OBJECTIVE: To describe the incidence and type of fetal injury identified in women undergoing cesarean delivery. METHODS: Between January 1, 1999, and December 31, 2000, a prospective cohort study of all cesarean deliveries was conducted at 13 university centers. Information regarding maternal and in...Birth Injuries; Cesarean Section; Adverse Effects2006-10
48 Varner, Michael W.Reduction in amniocentesis risks using a real-time needle guide procedure.Rates of complications associated with a second trimester genetic amniocentesis were studied in 918 patients, and complete infant follow-up was obtained. In 903 singleton pregnancies and 15 twin gestations, the procedure was performed under continuous sector scanning guidance through an attached nee...Amniocentesis; Ultrasonography; Pregnancy2007-01-25
49 Dolcourt, John L.; Hales, Joseph W.Use of internet searches for physician learningINTRODUCTION In 2005 the American Medical Association (AMA) approved the structure for awarding continuing medial education (CME) credit to physicians searching the Internet for answers to point-of-care related questions. Previous investigations of how physicians use the Intenet have relied on...Trapeze Interactive Poster2009
50 Gibbs, Katie Bernice; Frazer, John K.otg, a heritable T-cell malignancy in zebrafish that exhibits apoptosis resistanceOtg (oscar the grouch), a line of zebrafish identified with a T cell malignancy pseudoposition, has a recessive inheritance pattern with approximately 50% penetrance in presumed homozygotes (m/m). After breeding otg with a wild-type lck::eGFP fish to create obligate heterozygotes (+/m), and then in...otg; Oscar the grouch zebrafish; Apoptosis resistance; T cell malignancy; Pseudoposition; Trapeze Interactive poster2010-03-15
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