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Creator | Title | Description | Subject | Date |
26 |
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Askew, Eldon W.; Bernstein, Paul S. | Serum and macular responses to antioxidant supplementation verus a carotenoid-rich dietary intervention in the elderly. | The aim of this study was to observe responses of serum antioxidants, oxidative stress biomarkers, and macular carotenoid pigments to antioxidant supplements or dietary intervention in a single-masked, randomized, pilot clinical study of elderly subjects receiving antioxidant supplements or a dietar... | Macula; Serum Carotenoids; Zeaxanthin | 2006-02-01 |
27 |
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Normann, Richard A.; Johansson,Torbjorn; Abbasi, Masoud; Huber, Robert J. | Three-dimensional architecture for a parallel processing photosensing array | A three-dimensional architecture for a photosensing array has been developed. This silicon based architecture consists of a 10 x 10 array of photosensors with 80 microns diameter, through chip interconnects to the back side of a 500 microns thick silicon wafer. Each photosensor consists of a 300 x 3... | Retina; Optics; Silicon; Photosensing | 1992 |
28 |
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Normann, Richard A.; Jones, Kelly E. | Advanced demultiplexing system for physiological stimulation | A CMOS very large scale integration (VLSI) chip has been designed and built to implement a scheme developed for multiplexing/demultiplexing the signals required to operate an intracortical stimulating electrode array. Because the use of radio telemetry in a proposed system utilizing this chip may im... | Electrode Array; Stimulation; Telemetry; Microelectrodes; Transistors | 1997 |
29 |
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Creel, Donnell J.; Leventhal, Audie G. | Retinal projections in tyrosinase-negative albino cats | Retinal projections were examined in two tyrosinase-negative albino cats using autoradiographic techniques. Cats from this colony have pink eyes; their retinal pigment epithelium, ciliary body, and iris epithelium are completely devoid of melanin pigment. Test breeding for five generations indicates... | Cats; Albinism; Vision; Autoradiography; Retina | 1982-07 |
30 |
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Zhang, Kang; Yang, Zhenglin; Jiang, Li | Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q | Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal vascular system. Autosomal dominant FEVR is genetically heterogeneous, but its principal locus, EVR1, is on chromosome 11q13-q23. The gene encoding the Wnt receptor frizzled-4 (FZD4) was recently reported ... | Familial exudative vitreoretinopathy; FEVR; Inherited blinding disorders | 2004 |
31 |
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Baehr, Wolfgang; Zhang, Kang; Kolb, Helga | Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2 | PURPOSE: To identify gene arrangement, chromosomal localization, and expression pattern of mouse guanylate cyclase activating proteins GCAP1 and GCAP2, retina-specific Ca2+-binding proteins, and photoreceptor guanylate cyclase activators. METHODS: The GCAP1 and GCAP2 genes were cloned from genomic l... | Molecular Sequence Data; Guanylate Cyclase-Activating Proteins; In Situ Hybridization, Fluorescence | 1998 |
32 |
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Normann, Richard A.; Kolb, Helga; Lasater, Eric M. | Signal integration at the pedicle of turtle cone photoreceptors: an anatomical and electrophysiological study | The morphology of the axon which connects the cell body and pedicle of turtle cone photoreceptors was studied by light and electron microscopy. The axon which contains numerous synaptic vesicles, some endoplasmic reticulum, and a few cisternae is basically filled with cytoplasm. The length of the ax... | Cone Photoreceptor, Voltage Clamp; Isolated Cells; Input Resistance; Cell Body-Pedicle Coupling | 1989 |
33 |
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Baehr, Wolfgang | Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons | The second messengers cAMP and inositol-1,4,5-triphosphate have been implicated in olfaction in various species. The odorant-induced cGMP response was investigated using cilia preparations and olfactory primary cultures. Odorants cause a delayed and sustained elevation of cGMP. A component of this c... | Calcium-Binding Proteins; Nerve Tissue Proteins; Rats, Sprague-Dawley | 1998 |
34 |
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Normann, Richard A.; Muller, Jay F.; Kolb, Helga | Synaptic inputs to physiologically defined turtle retinal ganglion cells | Two physiologically distinct, HRP-marked turtle retinal ganglion cells were examined for their morphology, GABAergic, glycinergic, and bipolar cell synaptic inputs, using electron-microscopic autoradiography and postembedding immunocytochemistry. One cell was a color-opponent, transient ON/OFF gangl... | Turtles; Neural Pathways; Synapes; Retinal Ganglion Cells | 1991 |
35 |
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Olson, Randall J.; Pingree, Michael F.; Lundergan, Maureen K. | Penetrating keratoplasty for keratoconus: a long-term review of results and complications | PURPOSE: To study the long-term complications of penetrating keratoplasty (PKP) to evaluate current recommendations to patients with keratoconus. SETTING: John Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: Retrospective study of all PKP procedures for keratoconus performe... | Visual Acuity; Refraction, Ocular; Keratoconus; Astigmatism | 2000-07 |
36 |
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Olson, Randall J.; Mamalis, Nick; Spencer, Terrence S. | Postoperative sterile endophthalmitis (TASS) associated with the memorylens | PURPOSE: To report 10 cases of delayed-onset acute intraocular inflammation following cataract extraction and posterior chamber implantation of the MemoryLens(R) intraocular lens (IOL). SETTING: John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA. MET... | Memory Lens; Toxic Anterior Segment Syndrome; Retrospective Studies; adverse effects | 2000-12 |
37 |
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Normann, Richard A. | Background and bleaching adaptation in luminosity type horizontal cells in the isolated turtle retina | 1. The effects of background illumination and bleached photopigment on luminosity type horizontal cells were studied in the isolated turtle retina. 2. Background illumination, which produced less than 60% bleaching, hyperpolarized and desensitized the horizontal cells to a degree which depended upon... | Turtles; Retina; Photoreceptors; Bleached photopigment; Dark Adaptation | 1990 |
38 |
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Baehr, Wolfgang | Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction | Guanylyl cyclase activating protein (GCAP1) has been proposed to act as a calcium-dependent regulator of retinal photoreceptor guanylyl cyclase (GC) activity. Using immunocytochemical and biochemical methods, we show here that GCAP1 is present in rod and cone photoreceptor outer segments where photo... | Cloning, Molecular; DNA Primers; Molecular Sequence Data | 1995 |
39 |
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Olson, Randall J. | Wound complications associated with incision enlargement for foldable intraocular lens implantation during cataract surgery | PURPOSE: To determine the relationship between various intraocular lens (IOL) types and the incidence of unwanted light images. SETTING: The Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: A telephone questionnaire was administered to 302 postoperative patients who had rece... | Cararact Surgery; Incision Enlargement; Wound Complications; Vision Disorders | 2000-06 |
40 |
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Normann, Richard A.; Shah, Maulik R. | Study of printed spiral coils for neuroprosthetic transcranial telemetry applications | We have explored the use of printed spiral coils (PSC's) for neuroprosthetic transcranial telemetry applications. We fabricated two-dimensional PSC's on a thin (25 microns) polyimide substrate using copper (35 microns) as a conducting material. All the coils had a fixed inner diameter of 1.0 cm. We ... | Blindness; Neuroprosthesis; Transcranial Telemetry System; Prosthesis Design | 1998 |
41 |
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Bernstein, Paul S. | Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration | | | 2001 |
42 |
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Bernstein, Paul S. | Biochemical characterization of the retinoid isomerase system of the eye | We have previously shown that membranes from the retinal pigment epithelium can transform added all-trans-retinol into a mixture of 11-cis-retinoids, demonstrating the "missing reaction" in the visual cycle for the first time (Bernstein, P. S., Law, W. C., and Rando, R. R. (1987) Proc. Natl. Acad. S... | Hydrogen-Ion Concentration | 1987 |
43 |
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Olson, Randall J. | Update on a long-term, prospective study of capsulotomy and retinal detachment rates after cataract surgery | PURPOSE: To evaluate the retinal detachment risks and neodymium:YAG (Nd:YAG) capsulotomy rates associated with different cataract approaches and intraocular lens (IOL) styles in a long-term,prospective clinical study. SETTING: Clinical practice of 1 ophthalmologist, Fort Collins, Colorado, USA. METH... | Cataract Extraction; Laser Therapy; Retinal Detachment; Risk Factors | 2000-07 |
44 |
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Fu, Yingbin | Mechanism of reductive activation of potato tuber ADP-glucose pyrophosphorylase. | The potato tuber (Solanum tuberosum L.) ADP-glucose pyrophosphorylase activity is activated by a incubation with ADP-glucose and dithiothreitol or by ATP, glucose- 1-phosphate, Ca2+, and dithiothreitol. The activation was accompanied by the appearance of new sulfhydryl groups as determined with 5, 5... | Glucosephosphates; Enzyme Activation; Adenosine Triphosphate | 1998 |
45 |
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Zhang, Kang | Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities | PURPOSE: The PITX3 gene, which codes for a homeobox bicoidlike transcription factor is responsible for dominant cataract and anterior segment mesenchymal dysgenesis in humans. In the current study, a family with autosomal dominant posterior polar cataract (PPC) and a PITX3 mutation that cosegregates... | Chromosomes, Human, Pair 10; Homozygote; Lod Score | 2006 |
46 |
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Olson, Randall J. | Clinical comparison of single-piece and three-piece truncated hydrophobic acrylic intraocular lenses | PURPOSE: To determine the clinical differences between three-piece (3P) and single-piece (SP) truncated hydrophobic acrylic intraocular lenses (IOL). DESIGN: Retrospective cohort clinical study. METHODS: The setting was an academic clinical practice. The patient population consisted of subjects with... | Lenses, Intraocular; Patient Satisfaction; Postoperative Complications; Prosthesis Design; Visual Acuity | 2003-10 |
47 |
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Baehr, Wolfgang | Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction | PURPOSE: The light-dependent redistribution of phototransduction components in photoreceptor cells plays a role in light adaptation. Upon illumination, rod and cone arrestins (Arr and cArr) translocate from the inner to the outer segments while transducin subunits (Talpha, Tbetagamma) translocate in... | Phototransduction; Protein Kinases; Rhodopsin Kinase | 2003 |
48 |
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Baehr, Wolfgang | Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver | Lecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal pigmented epithelium, LRAT plays a key role in the retinoid cycle, a two-cell recycling system that replenis... | Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Microscopy, Fluorescence | 2004 |
49 |
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Olson, Randall J. | Clinical experience with 21-gauge manual microphacoemulsification using Sovereign WhiteStar Technology in eyes with dense cataract | PURPOSE: To present a series of patients who had 21-gauge microphacoemulsification using Sovereign WhiteStar technology. SETTING: John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. METHODS: Eighteen consecutive patients with cataracts judged to be 3+ or 4+ on... | Cataract; Microsurgery; Phacoemulsification; Postoperative Complications; Visual Acuity | 2004-01 |
50 |
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Olson, Randall J. | Effect of lens edge design versus anterior capsule overlap on posterior capsule opacification | PURPOSE: To determine whether lens edge design or anterior capsule overlap on the intraocular lens (IOL) has greater effect on posterior capsule opacification (PCO). DESIGN: Retrospective cohort clinical study. METHODS: Retrospective. SETTING: Academic clinical practice. PATIENT POPULATION: The pati... | Posterior Capsular Opacification' Intraocular Lens; Anterior Capsular Opacification; Acrylic Lenses; Silicone Lenses | 2004-10 |