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26 Kestle, John R. W.; Walker, Marion L.Noncommunicating spinal extradural arachnoid cyst causing spinal cord compression in a childExtradural arachnoid cysts in the spine are relatively uncommon causes of spinal cord compression in the pediatric population that are thought to arise from congenital defects in the dura mater. Most reports describe such cysts communicating with the intrathecal subarachnoid space through a small de...2006
27 Dailey, Andrew T.Diagnosis and treatment of craniocervical dislocation in a series of 17 consecutive survivors during an 8-year periodObject. Craniocervical dissociation (CCD) is a highly unstable and usually fatal injury resulting from osseoligamentous disruption between the occiput and C-2. The purpose of this study was to elucidate systematic factors associated with delays in diagnosing and treating this life-threatening condit...Spinal cord injury; Craniocervical dislocation; Atlantooccipital joint; Atlantoaxial joint; Tetraplegia; CCJ; CCD2006
28 Schmidt, Meic H.Photodynamic therapyWe appreciate the comments of Drs. Kaye and Hill on our article. We are pleased that these investigators concurred with our impression that photodynamic therapy (PDT) may potentially be useful in the treatment of posterior fossa tumors. Several interesting questions were raised about the technical ...Photodynamic therapy; Photofrin1994
29 Kestle, John R. W.Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshopObject. Treatment for hydrocephalus has not advanced appreciably since the advent of cerebrospinal fluid (CSF) shunts more than 50 years ago. Many questions remain that clinical and basic research could address, which in turn could improve therapeutic options. To clarify the main issues facing hydr...Biomedical research2007
30 Digre, Kathleen B.; Schmidt, Richard H.; Osborne, Anne G.; Patel, Bhupendra C.; Pratt, David; Rietz, Lisa A.Compressive optic neuropathy caused by renal osteodystrophy. Case report.Compressive optic neuropathy with acute or chronic vision loss has been associated with various skull base tumors, aneurysms, Graves disease, trauma, and, less commonly, fibrous dysplasia and osteopetrosis. The Author's present a case of acute visual deterioration in a 25-year-old woman who had mass...Optic Neuropathy; Optic Nerve Decompression; Renal Osteodystrophy2001-10
31 Couldwell, William T.Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C systemThe protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administrat...Protein kinase C; Phorbol ester; Cell proliferation; Tumor cell growth; Astrocyte; Glioma; Immunohistochemistry1990
32 Schmidt, Meic H.Benzoporphyrin derivative and light-emitting diode for use in photodynamic therapy: applications of space light-emitting diode technologyPhotodynamic therapy (PDT) is a cancer treatment modality that recently has been applied as adjuvant therapy for rain tumors. PDT consists of intravenously injecting a photosensitizer, which preferentially accumulates in tumor ells, into a patient and then activating the photosensitizer with a light...Benzoporphyrin; Photodynamic therapy; Brain tumors; Photofrin1998
33 Couldwell, William T.; House, Paul A.; Salzman, Karen L.; Osborne, Anne G.; MacDonald, Joel D.; Jensen, Randy L.Surgical considerations regarding giant dilations of the perivascular spacesObject. Dilations of brain perivascular spaces (PVSs), also known as Virchow-Robin spaces, are routinely identified on magnetic resonance imaging studies of the brain and recognized as benign normal variants. Giant dilations occur only rarely and can be easily misdiagnosed as central nervous system ...2004
34 Couldwell, William T.Diagnosis and management of Cushing diseaseThe management of a case involving Cushing disease, defined as excess secretion of adrenocorticotropic hormone (ACTH) from a pituitary adenoma, remains one of the most vexing problems facing the pituitary surgeon. The systemic consequences of this endocrinopathy are profound morbidity and premature...2007-01-01
35 Kestle, John R. W.Sporadic osteochondroma of the cervical spineOsteochondroma is the most common benign tumor of bone, but axial skeleton involvement is uncommon and usually indicates a hereditary cause such as osteochondromatosis (hereditary multiple exostosis). 1 Approximately 7% of hereditary osteochondromas occur along the vertebral column, which is double...2006
36 Schmidt, Meic H.Thoracoscopic spine surgery for decompression and stabilization of the anterolateral thoracolumbar spineThe anterior thoracolumbar spine can be exposed via a variety of approaches. Historically, open anterolateral or posterolateral approaches have been used to gain access to the anterior thoracolumbar spinal column. Although the exposure is excellent, open approaches are associated with significant pa...Endoscopic spinal surgery; Thoracic spine; Lumbar spine; Thoracoscopic spinal instrumentation2005
37 Couldwell, William T.Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic applicationProtein kinase C (PKC) is an enzyme involved in the regulation of cellular growth, proliferation, and differentiation in a number of tissues including the anterior pituitary, in which it is also believed to play a role in hormone secretion. Protein kinase C activity and expression have been found to...Apoptosis; Hypericin; Pituitary adenoma; Protein kinase C1996
38 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 9: fusion in patients with stenosis and spondylolisthesisGuidelines. The performance of a lumbar PLF is recommended for patients with lumbar stenosis and associated degenerative spondylolisthesis who require decompression. There is insufficient evidence to recommend a treatment guideline. Options. Pedicle screw fixation as an adjunct to lumbar PLF should ...Fusion; Lumbar spine; Degenerative disease; Lumbar fusion2005
39 Kestle, John R. W.Effect of single-application topical ophthalmic anesthesia in patients with trigeminal neuralgia: a randomized double-blind placebo-controlled trialTo evaluate the reported benefit of ipsilateral single-application ophthalmic anesthetic eyedrops in patients with typical trigeminal neuralgia, a randomized double-blind placebo-controlled trial was performed. Fortyseven patients were randomly assigned to receive two drops of either proparacaine (...Randomized trial; Ophthalmic anesthesia1994
40 Couldwell, William T.; Schloesser, Peter E.Hemorrhage from moyamoya-like vessels associated with a cerebral arteriovenous malformationThe authors describe a case of subarachnoid hemorrhage from moyamoya-like vessels associated with an arteriovenous malformation (AVM) in a 44-year-old Hispanic man who presented with severe headache. The AVM was located in the left parietal lobe and the ipsilateral middle cerebral artery was occlude...Moyamoya-like vessels; Arteriovenous malformation; Ischemia MeSH: Arteriovenous malformations2004
41 Couldwell, William T.Comment on Kitano, M., et al.: Subdural patch graft technique for watertight closure of large dural defects in extended transsphenoidal surgeryAhn and Kim demonstrate a suturing technique to close dural defects after transsphenoidal and extended transsphenoidal approaches. The technique entails a specifically designed forceps to cinch the knot down in the depths of the field. The Author's used the technique in 21 consecutive patients (16 e...Transsphenoidal surgery; CSF leaks2009
42 Kestle, John R. W.Comparison between magnetic resonance imaging and computed tomography for stereotactic coordinate determinationThe spatial accuracy of magnetic resonance imaging (MRI) has not been established for stereotactic surgery. Magnetic susceptibility artifacts may lead to anatomical distortion and inaccurate stereotactic MRI coordinates, especially when targets are in regions of the brain out of the center of the ma...Computed tomography; Stereotactic coordinates; Stereotactic surgery1992
43 Couldwell, William T.; Orlandi, Richard R.Carotid artery-sparing repair of a cavernous carotid artery pseudoaneurysmCarotid artery (CA) injury after transsphenoidal and endoscopic sinus surgery is a well-recognized but fortunately rare complication.1 It is associated with significant morbidity and mortality rates5 and is more common in cases of repeated surgery, cavernous sinus invasion, prior radiotherapy, and ...Carotid artery; Sinus; Pseudoaneurysm; Endoscopic surgery2006
44 Dailey, Andrew T.Agreement between orthopedic surgeons and neurosurgeons regarding a new algorithm for the treatment of thoracolumbar injuries: a multicenter reliability studyIntroduction: Considerable variability exists in the management of thoracolumbar (TL) spine injuries. Although there are many influences, one significant factor may be the treating surgeon's specialty and training (ie, orthopedic surgery vs. neurosurgery). Our objective was to assess the agreement ...Thoracolumbar injuries; Rating; Classification; TLISS; Neurosurgery; Interspeciality reliability2006
45 Couldwell, William T.Utilization of unilateral and bilateral stereotactically placed adrenomedullary-striatal autografts in Parkinsonian humans: rationale, techniques, and observationsA limited clinical pilot study involving an amalgam of specialized disciplines including neurology, neuropharmacology, neuropsychology, neurosurgery, neuroanesthesia, neuroradiology, surgical pathology, neuropathology, and urological surgery was organized to clarify issues related to patient selecti...Adrenal medullary graft; Autograft; Brain graft; Neural transplantation; Parkinsonism; Stereotaxy1990
46 Kestle, John R. W.High incidence of tumor dissemination in myxopapillary ependymoma in pediatric patientsP Myxopapillary ependymomas (MPEs) have historically been thought to be benign tumors occurring most frequently in adults. Only 8 to 20% of these tumors occur in the first two decades of life, making this tumor a rarity in pediatric neurosurgery. Five patients with intraspinal MPEs were treated by t...2005-01
47 Schmidt, Meic H.Embolization of sacral tumorsThe management of sacral tumors is challenging because of difficulties in accessing the lesion, the high rate of local recurrence, extensive vascularity causing significant intraoperative blood loss, resistance to radiation therapy, and risk of malignant transformation. Although surgery is the main ...Sacral tumor2003
48 Kestle, John R. W.; Brockmeyer, Douglas LeeComplications of intracranial pressure monitoring in children with head traumaObject. Intracranial pressure (ICP) monitoring has become routine in the management of patients with traumatic brain injury (TBI). Many surgeons prefer to use external ventricular drains (EVDs) over fiberoptic monitors to measure ICP because of the added benefit of cerebrospinal fluid drainage. The ...Head trauma; Ventriculostomy; External ventricular drain; Monitoring; Fiberoptic monitor2004
49 Dailey, Andrew T.Thoracolumbar spine trauma classification: the Thoracolumbar Injury Classification and Severity Score system and case examplesObject. The aim of this study was to review the Thoracolumbar Injury Classification and Severity Score (TLICS) and to demonstrate its application through a series of spine trauma cases. Methods. The Spine Trauma Study Group collaborated to create and report the TLICS system. The TLICS system is re...Thoracolumbar spine trauma; Classification; Thoracolumbar injury; TLICS; Spine Trauma Study Group; Thoracolumbar Injury Classification and Severity Score2009
50 Dailey, Andrew T.; Brodke, Darrel S.; Bachus, Kent N.Anterior cervical fixation: analysis of load-sharing and stability with use of static and dynamic platesBackground: Anterior plates provide stability following decompression and fusion of the cervical spine. Various plate designs have emerged, and they include static plates with fixed-angle screws, rotationally dynamic plates that allow the screws to toggle in the plate, and translationally dynamic pl...Anterior cervical fixation; Load-sharing; Stability; Static plates; Dynamic plates2006
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