Honors Theses Open Access
 
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26 Spurlock, Ella K.Exploration of the 2-dimensional π-d conjugated coordination polymer Cu-benzenehexathoilCoordination polymers (CPs) are a type of atomically precise material that has long been an area of study for materials chemists. Recently, research has advanced with twodimensional conjugated CPs as detailed synthetic schemes are developed to create highly atomically ordered, large-area sheets. The...2022
27 Coplan, Caitlin DeniseFabrication and Application of Aluminum NanostructuresPlasmonics, the phenomenon resulting from light interactions with nanoscale structures, is an active field for nanoscale manipulation of light. By varying the metal, size, and shape, plasmonic nanostructures can be tuned to interact with a broad spectral range of light. Commonly used plasmonic mater...2019
28 Borodai, Anastasia S.Faraday @ Home Continuing Faraday from the "U" to the YouthRecent attention has been brought to light in the United States regarding the lack of students pursuing STEM disciplines and degree programs. There is a considerable amount of research on the importance of STEM (Science, Technology, Engineering and Math) Education at an early onset age. With this is...2017
29 Ridge, Rachel KatherineFlagellar Protein Flhe Influences Motility and Morphology Through Regulation of Assembly in Escherichia ColiThe bacterial flagellar motor is a remarkably complex system, comprising thousands of protein subunits and responsible for motility in numerous species. Of these proteins, FlhE is not universally conserved and is relatively understudied. Usually found cotranscribed with flhB and flhA in the flhBAE o...2017
30 Narasipura, Eshan AmruthFull synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycinTargeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-...2021
31 Capener, JacobG Protein-Coupled resecptor kinase 2 mediated phosphorylation for The Activation of SmoothenedThe Hedgehog (Hh) pathway is a cell signaling pathway that is involved in embryonic development and adult tissue maintenance in vertebrates. Improper functioning of this pathway can lead to developmental disorders and several forms of cancer. Despite the pathway's biological importance, the transduc...2020
32 Jones, Kathryn K.Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation CatalysisMetallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini...2020
33 Black, AlyssaIdentifying hybrid male sterility genes in Drosophila PseudoobscuraSpeciation, the process of one species splitting into two separate species, often involves the evolution of hybrid sterility or hybrid inviability. These reproductive isolating barriers are caused by negative interactions between genes called hybrid incompatibilities. Identifying hybrid incompatibil...Infertility, Male -- Genetic aspects Drosophila pseudoobscura -- Genetics Male sterility genes2015-05
34 Khuu, ScottIdentifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal TransitionCancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski...2017
35 Owen, Cameron J.Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie CationsEmployment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate...2019
36 Zurbuchen, RudiMacrocyclization of glucagon-like peptide (GLP-1) by thiol-ene reactionMacrocyclization of peptides helps maintain a stable alpha helical structure using a conformational constraining staple. One such peptide, glucagon-like peptide-1 (GLP-1), is a 37 amino acid peptide agonist for the GLP-1 receptor and has the ability to lower blood glucose levels and is responsible ...Peptide hormones - Receptors - Research; Ring formation (Chemistry) - Research; Macrocyndization; GLP-1; Swim kinematics; Pre-pulse inhibition2016-05
37 Franchina, Jordan AveryMeasurement of bond dissociation energies of transition metal moleculesMeasuring thermochemical and kinetic properties of chemical systems has always; been a central theme of chemistry. Knowing these properties assists us in assessing; whether or not a chemical reaction is energetically feasible, efficient, and worthwhile.; Theoretical chemistry has now developed suffi...Chemical systems; thermochemical; kinetic; modeling2018-04
38 Scholl, WallisNanomite-Decorated Nanoparticles as Surface-Enhanced Spectroscopy SubstratedSurface-enhanced spectroscopy substrates utilize the localized surface plasmon resonance of nanoparticles for optical, photocatalysis, and biological and chemical sensing applications. Plasmonic anisotropic nanoparticles with sharp tips focus the electromagnetic field of the localized surface plasmo...2020
39 Cowley, JacobOptimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynesIn order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the...2021
40 Fox, ZachThe physical effects of solvent in molecule-based magnetsMolecule-based magnets are being studied in order to expand the utility of magnets in modern devices. Advantages of molecule-based magnets include less energy intensive synthesis and greater versatility through changes to organic components of the structure. This class of materials is studied to ena...Magnets - Experiments2012-05
41 Duffin, CalderSequence Activity Relaqtionships in a Radical Sam Peptide MaturaseRibosomally synthesized and post-translationally modified peptide Tte1186a and several point mutation variants are synthesized using solid phase peptide synthesis with FMOC amino acids. Substrate recognition and thioether linkage formation from the radical S-adenosyl methionine Tte1186 maturase is d...2020
42 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
43 Farrall, NicholasStructural characterization of the full-length exocyst complex by transmission electron cryo-microscopyThe exocyst is a conserved octameric protein complex in eukaryotes that is essential for tethering and fusion of vesicles to the plasma membrane. Composed of eight subunits, it is essential for growth, secretion, and developmental processes and has been implicated in cell motility, autophagy, cell d...Saccaromyces cerevisaie - Cytology; Cryomiscroscopy - Research2014-05
44 Reece, Eric J.Synthesis and Characterization of Proton Conducting Silica Nano-Particles for use in Polymer Electrolyte Membrane Fuel CellsOne of the fastest growing fields in scientific research is alternative energy. This has led to an investigation into the various aspects of fuel cells and their components due to their highly efficient energy conversion and low CO2 emissions. The efficiency of fuel cells is highly dependent on the ...2019
45 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
46 Randolph, CharlotteSynthesis of VLC-Pufas relating to macular degenerative diseasesVery Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb...2022
47 Aderibigbe, JustisTrends in the usage of bidentate phosphines as ligands in nickel catalysis of hydrogenation reactionsA critically important process in catalysis is the formation of an active catalyst from the combination of a metal precursor and a ligand, as the efficacy of this reaction governs the amount of active catalyst. This review is a compacted but comprehensive review of reactions catalyzed by nickel and ...2021
48 Walker, KortnieUnderstanding and treating diabetic retinopathyDiabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre...Diabetic retinopathy2015-05
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