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Creator | Title | Description | Subject | Date |
26 |
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Narasipura, Eshan Amruth | Full synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycin | Targeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-... | | 2021 |
27 |
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Randolph, Charlotte | Synthesis of VLC-Pufas relating to macular degenerative diseases | Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb... | | 2022 |
28 |
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Spurlock, Ella K. | Exploration of the 2-dimensional π-d conjugated coordination polymer Cu-benzenehexathoil | Coordination polymers (CPs) are a type of atomically precise material that has long been an area of study for materials chemists. Recently, research has advanced with twodimensional conjugated CPs as detailed synthetic schemes are developed to create highly atomically ordered, large-area sheets. The... | | 2022 |
29 |
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Fernandez, Florence | Evaluation of environmental education in high school science courses across Salt Lake City, Utah | While the effects of pollution become Incredibly more evident in the air of the Salt Lake Valley, many Utah high school students still lack the knowledge and information necessary to take preventative and immediate actions to protect their health and their environment. In this study, the reasons for... | Environmental education -- Utah -- Salt Lake City; Science -- Study and teaching -- Utah -- Salt Lake City; Air -- Pollution -- Utah -- Salt Lake City | 2015-05 |
30 |
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Fan, Huijun | Examination of Y-Deterium isotope effects for the solvolysis of model isoprenoid compounds | Model isoprenoid compounds can undergo two distinct pathways, dissociative or associative nucleophilic substitution depending on the conditions used. The dissociative pathway consists of two steps, involving a carbocation intermediate where the formation of that carbocation is rate determining. The ... | Isopentenoids; Solvolysis; Deuterium - Isotopes | 2012-05 |
31 |
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Khuu, Scott | Identifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal Transition | Cancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski... | | 2017 |
32 |
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Black, Alyssa | Identifying hybrid male sterility genes in Drosophila Pseudoobscura | Speciation, the process of one species splitting into two separate species, often involves the evolution of hybrid sterility or hybrid inviability. These reproductive isolating barriers are caused by negative interactions between genes called hybrid incompatibilities. Identifying hybrid incompatibil... | Infertility, Male -- Genetic aspects Drosophila pseudoobscura -- Genetics Male sterility genes | 2015-05 |
33 |
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Jones, Kathryn K. | Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation Catalysis | Metallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini... | | 2020 |
34 |
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Walker, Kortnie | Understanding and treating diabetic retinopathy | Diabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre... | Diabetic retinopathy | 2015-05 |
35 |
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Owen, Cameron J. | Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie Cations | Employment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate... | | 2019 |
36 |
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Godfrey, Rose | A porcine model for the development and testing of preoperative skin preparations | Clinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu... | | 2022 |
37 |
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Galinat, Shelby | Bipyrimidine solubility modeling for applications in NON-Aqueous redox flow batteries | Energy storage research has undergone transformative changes in the past 50 years. The increasingly concerning threat of climate change has emphasized the need for energy storage technology to facilitate renewable energy incorporation into the grid. Without energy storage, the fluctuations of wind a... | | 2022 |
38 |
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Kim, Alexander H. | DPP Signal Regulation Through O-Linked Glycosylation | Dorsal closure in Drosophila is an embryogenic event that involves coordinated cellular shape changes. A series of interconnected signaling cascades are utilized to accomplish this task, one of which is the Decapentaplegic (Dpp) pathway. Dpp is a member of the TFG-β family of secreted cytokines, wh... | | 2017 |
39 |
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Bischoff, Amanda | Elucidating the Mechanism and Predicting the Selectivity of the bis(Pyridine) Silver Permanganate Oxidatiin | The Movassaghi group has recently reported several total syntheses of epipolythiodiketopiperazine derivatives (ETPs), a class of natural products with potent biological activity. A crucial step in their synthesis oxidizes two to four tertiary C-H bonds to form tertiary alcohols using (bis)pyridine s... | | 2016 |
40 |
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Visser, Joshua | Characterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongation | Guanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca... | DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers | 2016-05 |
41 |
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Nicolo, Tera | Characterization of mitochondria-modified electrodes | In order to develop an herbicide sensor, yeast, potato, and bovine heart mitochondria were isolated and immobilized onto Toray paper electrodes. Cyclic voltammetry showed two redox peaks at 186 ± 14 mV vs. SCE and -357 ± 24 mV vs. SCE with an E1/2 of -128 mV. Scan rate studies suggested the proces... | Electrodes; Herbicides - Detection | 2013-05 |
42 |
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Simonsen, Kyle | Breast cancer knowledge and attitudes among women in Armenia | Background: Breast cancer, the most common invasive cancer among women, has high incidence and mortality rates among women in the Republic of Armenia. Advanced stage at detection limits treatment options and contributes to high morbidity and mortality. Understanding women's breast cancer knowledge a... | Breast - Cancer; Breast - Cancer - Patients - Attitudes; Breast - Cancer - Patients - Armenia (Republic) | 2013-07 |
43 |
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Pecchia-Bekkum, Annika | Applications of controlled DNA assembly and disassembly in biosensing and responsive drug delivery | Deoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In... | Nucleic acids - Biotechnology | 2013-08 |
44 |
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Kent, Alexandra | DNA split aptamers as a biosensing platform for the detection of small drug molecules | Prescription drug overdose and abuse is a leading cause of death in the United States. It is a serious issue and has become increasingly problematic as opioids are being prescribed with a higher frequency. For this reason, fast, accurate detection of small drug molecules is crucial. The current stan... | Drug testing; Biosensors; DNA split aptamers | |
45 |
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Reece, Eric J. | Synthesis and Characterization of Proton Conducting Silica Nano-Particles for use in Polymer Electrolyte Membrane Fuel Cells | One of the fastest growing fields in scientific research is alternative energy. This has led to an investigation into the various aspects of fuel cells and their components due to their highly efficient energy conversion and low CO2 emissions. The efficiency of fuel cells is highly dependent on the ... | | 2019 |
46 |
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Arave, Rowan A. | AKT1 activation promotes the development of melanoma metastasis | Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu... | Melanoma - Genetics - Research; Metastasis - Genetics - Research; Biochemistry; Genetics | 2015-12 |
47 |
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Lutz, Kevin | Discovery of platinum (II) cocrystals with highly fluorinated cyanocarbons | This thesis investigates new platinum(II) complex cocrystals with highly fluorinated cyanoaromatics. While π stacking compounds of polycyclic aromatic hydrocarbons and cyanoaromatics have been reported, interactions with transition metal complexes have yet to be explored. Crystal structures for (pp... | | 2023 |
48 |
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Cowley, Jacob | Optimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynes | In order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the... | | 2021 |
49 |
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Hansen, Mason | Intereferon gamma inducible nampt and its role in resisting cancer cell growth | | | 2023 |