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CreatorTitleDescriptionSubjectDate
351 Ehleringer, James R.Study of ecosystems in the context of global changeGlobal change research requires not only knowledge of how individual species (e.g. pests) respond to climate and land-use change, but also an understanding of the responses of whole systems to their multiple and interacting drivers. An upscaling from single systems to landscapes and continents is an...Ecosystems; Global change1999
352 Rogers, Alan R.Sociobiology of sex and sexes (comment)A comment on "Sociobiology of sex and sexes" by Marion Blute.Sociobiology; Sex and sexes1984-04
353 Bastiani, MichaelPathfinding by neuronal growth cones in grasshopper embryo: III. Selective affinity of the G growth cone for the P cells within the A/P fascicleThe growth cone of the G neuron selectively fasciculates upon specific axon bundles in a stereotypic sequence as it navigates through the developing central nervous system of the grasshopper embryo. It turns and extends anteriorly in the contralateral neuropil of the second thoracic ganglion at a s...Axon; Filopodia; Neuropil1984
354 Moon, Ann M.; Capecchi, Mario R.Roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the in...Animals; Apoptosis; Forelimb; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice, Mutant Strains; Trans-Activators2004-09
355 Capecchi, Mario R.Hoxc13 mutant mice lack external hairHox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibri...Filiform papillae; Homozygotes; Paralogous1998-01-01
356 Capecchi, Mario R.Hematopoietic origin of pathological grooming in Hoxb8 mutant miceMouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal similar to humans with OCD-spectrum disorder trichotillomania. Since Hox gene disruption often has pleiotropic effects, the root cause of this behavioral deficit was unclear. Here we report that, in the b...2010
357 Yamaguchi, AyakoRhythm generation, coordination, and initiation in the vocal pathways of male African clawed frogscentral pattern generator; vocalization; parabrachial area; hindbrain; bilateral coordination; motor programs2016
358 Capecchi, Mario R.Hox11 paralogous genes are essential for metanephric kidney inductionThe mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phen...Metanephric; Six2; Wt12002-06-01
359 Olivera, Baldomero M.Pyridine nucleotide metabolism in Escherichia coli. I. Exponential growthThe pyridine nucleotide pool of Escherichia coli is made up almost exclusively of DPN and TPN. In an exponentially growing glucose culture an average cell contains 1,460,000 molecules of DPN (30% reduced) and 440,000 molecules of TPN (57% reduced). If the total volume of the cell were accessible t...Nicotinic acid1971
360 Beckerle, Mary C.Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated plateletsActivation of blood platelets triggers a series of responses leading to the formation and retraction of blood clots. Among these responses is the establishment of integrin-mediated transmembrane connections between extracellular matrix components and the actin cytoskeleton of the platelet.Actin; GPIIb-IIIa1993
361 Olivera, Baldomero M.; McIntosh, J. MichaelSolution structure of αA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineusWe report the solution three-dimensional structure of an αA-conotoxin EIVA determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. The αA-conotoxin EIVA consists of 30 amino acids representing the largest peptide among the α/αAfamily conotoxins discovered so f...Conotoxins; A-conotoxin EIVA; Conus ermineus2003
362 Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. MichaelDifferential targeting of nicotinic acetylcholine receptors by novel αA-conotoxinsWe describe the isolation and characterization of two peptide toxins from Conus ermineus venom targeted to nicotinic acetylcholine receptors (nAChRs). The peptide structures have been confirmed by mass spectrometry and chemical synthesis. In contrast to the 12-18 residue, 4 Cys-containing α-co...Conotoxins; aA-conotoxins; Conus ermineus; Peptide toxins1997
363 Capecchi, Mario R.Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in miceAngiotensin-converting enzyme (ACE) produces the vasoconstrictor angiotensin II. The ACE protein is composed of two homologous domains, each binding zinc and each independently catalytic. To assess the physiologic significance of the two ACE catalytic domains, we used gene targeting in mice to int...2004-02-13
364 Gesteland, Raymond F.; Atkins, John F.; Tuohy, Therese M.Uninterrupted translation through putative 12-nucleotide coding gap in sequence of carA: business as usualPrevious work of others reported an untranslated stretch of 12 nucleotides in the 5' coding sequence of carA from Pseudomonas aeruginosa. However, N-terminal protein sequencing of carA-lacZ translational fusions shows that these 12 nucleotides are normally translated in a continuous triplet manner, ...Base Sequence; Protein Biosynthesis; Sequence Deletion1994
365 Capecchi, Mario R.Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.Although the role of Hox genes in patterning the mammalian body plan has been studied extensively during embryonic and fetal development, relatively little is known concerning Hox gene function in adult animals. Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous g...Embryonic and Fetal Development; Gene Expression Regulation, Developmental; Genotype; Mice, Knockout1999-01
366 Beckerle, Mary C.; Clark, Kathleen A.Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegansWe describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula...LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development1999
367 Adler, Frederick R.; Feener, Donald H.Maintaining diversity in an ant community: modeling, extending, and testing the dominance-discovery trade-offAnt communities often consist of many species with apparently similar niches. We present a mathematical model of the dominance-discovery trade-off, the trade-off between the abilities to find and to control resources, showing that it can in principle facilitate the coexistence of large numbers of s...Coexistence; Dominant species; Parasitoid2007
368 Davidson, Diane W.Microtopography of microbiotic crusts on the Colorado Plateau, and distribution of component organismsWe analyzed the microtopography of microbiotic soil crusts at 3 sites on the Colorado Plateau of southern Utah and investigated distributions of cyanobacteria and several lichens in distinctive microhabitats created by this topography. At all 3 sites the long axes of linear soil mounds were oriented...Microtopography; Microbiotic crusts; Colorado Plateau; Cryptobiotic soil; Colonization; Nonrandom orientation; Exposure; Collema; Disturbance history; Microhabitat2000
369 Lawton, Kristy J.Motor neurons tune premotor activity in a vertebrate central pattern generatorCentral patterns generators (CPGs) are neural circuits that drive rhythmic motor output without sensory feedback. Vertebrate CPGs are generally believed to operate in a top-down manner in which premotor interneurons activate motor neurons that in turn drive muscles. In contrast, the frog (Xenopus la...CPG; feed back; synchrony; vocal; vocalization; Xenopus2017
370 Clayton, Dale H.Nocturnal foraging of yellow-crowned night herons in the BahamasDetailed observations of nocturnal foraging of the Yellow-crowned Night Heron (Nycticorax violacevs) are not to be found in the literature, though this species commonly feeds at night (Kushlan 1978, Riegner 1982a). I observed several Yellow-crowned Night Herons foraging during November and December...Nocturnal foraging; Bahamas; Nycticorax violacevs1985
371 Bohs, Lynn A.Phylogeny and provisional classification of the Solanaceae based on chloroplast DNAA phylogenetic analysis of the Solanaceae based on chloroplast DNA variation is presented. Restriction site maps were determined for 79 species (52 genera) for 11 restriction enzymes.rbcL; ndhF; Chloroplast DNA1999
372 Olivera, Baldomero M.Pyridine nucleotide metabolism in Escherichia coli. II. Niacin starvationThe effect of niacin starvation has been studied in a niacin-requiring auxotroph of Escherichia coli. If a culture is totally deprived of niacin, cells continue to divide until the total pyridine nucleotide content has fallen from 1.9 X 10^6 to 1.2 X 10^5 molecules per cell. During starvation, the r...Starvation; Nicotinic acid1973
373 Coley, Phyllis D.On turning green into goldAnthropogenic effects on the climate and biodiversity of our planet are among the most troubling and perhaps irreversible threats facing scientists, policymakers, and citizens. Yet many scientists are reluctant or unsure of how to apply their expertise in basic science to these pressing real-world p...Bioprospecting; Drug discovery; Active compounds; Panama2008
374 Adler, Frederick R.Balance of terror: an alternative mechanism for competitive trade-offs and its implications for invading speciesThis article uses models to propose an explanation for three observations in community ecology: the apparent overreaction of prey to attack by specialist predators, the existence of a common trade-off among components of competitive ability in communities of unrelated competitors, and the ability of...Models; Curve; Native1999
375 Adler, Frederick R.Aggregation and stability in parasite-host modelsThis paper generalizes the two-dimensional approximation of models of macroparasites on homogeneous populations developed by Anderson & May (1978), focusing on how the dispersion (the variance to mean ratio) of the equilibrium distribution of parasites on hosts is related to the stability of the equ...Aggregation; Stability; Host-parasite models1992-04
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