|
|
Creator | Title | Description | Subject | Date |
| 351 |
 |
Capecchi, Mario R. | Male fertility is dependent on dipeptidase activity of testis ACE. | Testis angiotensin-converting enzyme (ACE) is an isozyme exclusively expressed by developing sperm. This protein has only a single catalytic domain containing the HEXXH consensus-site motif typical of zinc metallopeptidases. The exact role of testis ACE is unknown, but male mice lacking the protein ... | Amino Acid Motifs; Blotting, Western; Catalytic Domain; Comparative Study; Isoenzymes; Protein Structure, Tertiary | 2005-11-11 |
| 352 |
 |
Sekercioglu, Cagan | Mapping functional traits: comparing bundance and presence-absence estimates at large spatial scales | Efforts to quantify the composition of biological communities increasingly focus on functional traits. The composition of communities in terms of traits can be summarized in several ways. Ecologists are beginning to map the geographic distribution of trait-based metrics from various sources of data,... | | 2012-01-01 |
| 353 |
 |
Adler, Frederick R. | Mathematical model of a three-stage innate immune response to a pneumococcal lung infection | Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease. We combine bacterial titer measurements from mice infected with Streptococcus pneumoniae with mat... | | 2011 |
| 354 |
 |
Adler, Frederick R. | Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death | Acetaminophen is the leading cause of acute liver injury in the developed world. Timely administration of N-Acetylcysteine (N-Ac) prevents the progression of serious liver injury and disease, while failure to administer N-Ac within a critical time frame allows disease progression and in the most sev... | | 2012-01-01 |
| 355 |
 |
Beckerle, Mary C. | Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers | Actin stress fibers (SFs) in live cells consist of series of dynamic individual sarcomeric units. Within a group of consecutive SF sarcomeres, individual sarcomeres can spontaneously shorten or lengthen without changing the overall length of this group, but the underlying mechanism is unclear. We us... | | 2014-01-01 |
| 356 |
 |
Adler, Frederick R. | Mathematical modeling the age dependence of Epstein-Barr virus associated infectious mononucleosis | Most people get Epstein-Barr virus (EBV) infection at young age and are asymptomatic. Pri-mary EBV infection in adolescents and young adults however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue, and sore throat that can persist for months. Expansion in the num... | | 2012 |
| 357 |
 |
Adler, Frederick R. | Mathematical modeling the age dependence of Epstein-Barr virus associated infectious mononucleosis | Most people get Epstein-Barr virus (EBV) infection at young age and are asymptomatic. Primary EBV infection in adolescents and young adults however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue, and sore throat that can persist for months. Expansion in the numb... | | 2011 |
| 358 |
 |
Capecchi, Mario R. | Measurement of suppressor transfer RNA activity. | Transfer RNA (tRNA) suppression of nonsense mutations in prokaryotic systems has been widely used to study the structure and function of different prokaryotic genes. Through genetic engineering techniques, it is now possible to introduce suppressor (Su+) tRNA molecules into mammalian cells. A quanti... | Animals; Cells, Cultured; Eukaryotic Cells; Genes, Viral; Mice; Orthomyxoviridae; Peptide Chain Termination, Translational; Protein Biosynthesis | 1983-08-26 |
| 359 |
 |
Sekercioglu, Cagan | Measuring the meltdown: drivers of global amphibian extinction and decline | Habitat loss, climate change, over-exploitation, disease and other factors have been hypothesised in the global decline of amphibian biodiversity. However, the relative importance of and synergies among different drivers are still poorly understood. We present the largest global analysis of roughly ... | | 2008-01-01 |
| 360 |
 |
Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. Joseph | Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement | Organs and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev... | Zyxin; Actin | 2005 |
| 361 |
 |
Hughes, Kelly T.; Chevance, Fabienne | Mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution | The rod component of the bacterial flagellum polymerizes from the inner membrane across the periplasmic space and stops at a length of 25 nm at the outer membrane. Bushing structures, the P- and L-rings, polymerize around the distal rod and form a pore in the outer membrane. The flagellar hook stru... | Flagellar assembly; Spirochete evolution; Membrane penetration | 2007 |
| 362 |
 |
Beckerle, Mary C. | Members of the zyxin family of LIM proteins interact with members of the p130cas family of signal transducers | Integrin binding to extracellular matrix proteins induces formation of signaling complexes at focal adhesions. Zyxin co-localizes with integrins at sites of cellsubstratum adhesion and is postulated to serve as a docking site for the assembly of multimeric protein complexes involved in regulating ce... | Zyxin; Actin; LIM domains; Trip6; Focal adhesions | 2002 |
| 363 |
 |
Blair, David F. | Metal centers of cytochrome c oxidase: structures and interactions | Studies directed toward the elucidation of the structures of the metal centers in cytochrome c oxidase are reviewed. Progress towards an understanding of the interactions between these centers and their spatial distributions within the protein will also be presented. Our studies are based primarily... | | 1983 |
| 364 |
 |
Potts, Wayne K. | MHC signaling during social communication | The major histocompatibility complex (MHC) has been known to play a critical role in immune recognition since the 1950s. It was a surprise, then, in the 1970s when the first report appeared indicating MHC might also function in social signaling. Since this seminal discovery, MHC signaling has been f... | | 2012-01-01 |
| 365 |
 |
Capecchi, Mario R. | Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II | Recently, the concept of local renin-angiotensin systems (RAS) capable of generating angiotensin II apart from the circulation has received considerable attention. To investigate this, we generated ACE 1/3 mice in which one allele of ACE is null and the second allele was engineered to express ACE o... | | 2003 |
| 366 |
 |
Capecchi, Mario R. | Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure | To test the hypothesis that local vascular production of angiotensin II is necessary for the normal regulation of blood pressure, we engineered a new line of genetically altered mice that lack endothelial angiotensin-converting enzyme (ACE). This was accomplished using a novel strategy of targeted... | | 2002 |
| 367 |
 |
Capecchi, Mario R. | Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death | To investigate the local effects of angiotensin II on the heart, we created a mouse model with 100-fold normal cardiac angiotensin-converting enzyme (ACE), but no ACE expression in kidney or vascular endothelium. This was achieved by placing the endogenous ACE gene under the control of the α-myo... | Atrial enlargement; Cardiac arrhythmia; ACE | 2004 |
| 368 |
 |
Capecchi, Mario R. | Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma | Angiotensin-converting enzyne (ACE) is a pepitdase responsible for the cleavage of angiotensin I and Several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10... | Macrophage enzyme; Melanoma resistance; Enhanced macrophage angiotensin-converting enzyme | 2007 |
| 369 |
 |
Capecchi, Mario R. | Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. | The Hox genes encode transcription factors which mediate the formation of the mammalian body plan along the anteroposterior and appendicular axes. Paralogous Hox genes within the separate linkage groups are closely related with respect to DNA sequence and expression, suggesting that they could have ... | Animals; Atlas; Homozygote; Mice; Models, Genetic | 1994-07-28 |
| 370 |
 |
Beckerle, Mary C. | Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells | Microinjected 0.26-um fluorescent, carboxylated microspheres were found to display classical saltatory motion in tissue culture cells . The movement of a given particle was characterized by a discontinuous velocity distribution and was unaffected by the activity of adjacent particles. | Organelles; Microscopy; Proteins | 1984 |
| 371 |
 |
Davidson, Diane W. | Microtopography of microbiotic crusts on the Colorado Plateau, and distribution of component organisms | We analyzed the microtopography of microbiotic soil crusts at 3 sites on the Colorado Plateau of southern Utah and investigated distributions of cyanobacteria and several lichens in distinctive microhabitats created by this topography. At all 3 sites the long axes of linear soil mounds were oriented... | Microtopography; Microbiotic crusts; Colorado Plateau; Cryptobiotic soil; Colonization; Nonrandom orientation; Exposure; Collema; Disturbance history; Microhabitat | 2000 |
| 372 |
 |
Adler, Frederick R. | Migration alone can produce persistence of host-parasitoid models | It has long been recognized that the unstable equilibrium of a single-patch predator-prey model cannot be stabilized by diffusive coupling with identical patches, since the coupled system acts exactly like the single-patch system if the patches are synchronized (Maynard Smith 1974; Allen 1975; Reeve... | Heterogeneity; Nicholson-Bailey; migration rates | 1993 |
| 373 |
 |
Capecchi, Mario R. | Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment | Alveolar soft part sarcoma (ASPS), a deadly soft tissue malignancy with a predilection for adolescents and young adults, associates consistently with t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3. We proved the oncogenic capacity of this fusion gene by driving sarcomagenesis in m... | | 2014-01-01 |
| 374 |
 |
Seger, Jon | Models of sex ratio evolution | Our understanding of sex ratio evolution depends strongly on models that identify: (1) constraints on the production of male and female offspring, and (2) fitness consequences entailed by the production of different attainable brood sex ratios. Verbal and mathematical arguments by, among others, D... | Fitness; Species; Sex-allocation | 2002 |
| 375 |
 |
Olivera, Baldomero M. | Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails | Background: Conotoxins can be utilized to investigate enzyme-assisted folding of disulfide-rich peptides. Results: Various ER-resident cone snail enzymes act in concert to accelerate the oxidative folding of conotoxins and modulate their conformation by reconfiguring disulfide connectivities. Conclu... | | 2012-01-01 |
