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Creator | Title | Description | Subject | Date |
| 326 |
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Shapiro, Michael D. | Limb diversity and digit reduction in reptilian evolution | The study of morphological rules, or trends, offered classical biologists the opportunity to address the mechanisms underlying the evolution of anatomical designs. Regularities in evolution suggested that common functional or developmental rules governed the transformation of structures. Parallelism... | Digit loss; Morphology; Adaptation | 2006 |
| 327 |
 |
Olivera, Baldomero M.; ; McIntosh, J. Michael | Localization of [125I] ω-conotoxin GVIA binding in human hippocampus and cerebellum | THE peptide toxin ω-conotoxin GVIA (ω-CgTx) has been shown to be a high affinity ligand for N-type calcium channels in the brain. We have employed [125I]ω-CgTx to localize N-type channels in human hippocampus and cerebellum using autoradiography. Ten micron thick slidemounted tissue sections of... | Conotoxins; Peptide toxins | 1993 |
| 328 |
 |
Capecchi, Mario R. | Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. | Biochemical transformation of thymidine-kinase-deficient (TK-) mouse L cells is enhanced 20 to 40 fold when microinjected plasmid DNA contains regions of the genomes of Rous sarcoma virus or simian virus 40 in addition to the complete herpes simplex virus tk gene, irrespective of the orientation and... | Animals; Base Sequence; Genes, Viral; Plasmids; Thymidine Kinase | 1983-07-01 |
| 329 |
 |
Thomas, Kirk R.; Capecchi, Mario R. | Location of crossovers during gene targeting with insertion and replacement vectors. | Gene targeting was used to introduce nonselectable genetic changes into chromosomal loci in mouse embryo-derived stem cells. The nonselectable markers were linked to a selectable marker in both insertion- and replacement-type vectors, and the transfer of the two elements to the Hprt locus was assaye... | Genetic Vectors; Molecular Sequence Data; Restriction Mapping | 1993-04 |
| 330 |
 |
Adler, Frederick R. | Long-term models of oxidative stress and mitochondrial damage in insulin resistance progression | Insulin resistance, characterized by a reduced cellular response to insulin, is a major factor in type 2 diabetes pathogenesis, with a complex etiology consisting of a combination of environmental and genetic factors. Oxidative stress, which develops through an accumulation of toxic reactive oxygen ... | | 2014-01-01 |
| 331 |
 |
Bastiani, Michael | Loss of axons in the cat optic nerve following fetal unilateral enucleation: an electron microscopic analysis | Between the 48th day of gestation (E-48) and maturity, the number of axons in the cat optic nerve is reduced by approximately 50%. On the basis of an electron microscopic assay, the axon population of the E-48 nerve was estimated to be 328,000. In contrast, estimates from two normal adults were 159,... | Ganglion cell death; Retinofugal projection; Retinal ganglion cell axons | 1983 |
| 332 |
 |
Goller, Franz | Low-dimensional dynamical model for the diversity of pressure patterns used in canary song | During song production, oscine birds produce large air sac pressure pulses. During those pulses, energy is transferred to labia located at the juncture between the bronchii and the trachea, inducing the high frequency labial oscillations which are responsible for airflow modulations, i.e., the utt... | Serinus canarias; Air sac pressure | 2009-04 |
| 333 |
 |
Adler, Frederick R.; Liou, Theodore G.; Cahill, Barbara C. | Lung transplantation and survival in children with cystic fibrosis | The effects of lung transplantation on the survival and quality of life in children with cystic fibrosis are uncertain. We used data from the U.S. Cystic Fibrosis Foundation Patient Registry and from the Organ Procurement and Transplantation Network to identify children with cystic fibrosis who were... | Life; Infection; Risk; Harm | 2007 |
| 334 |
 |
Potts, Wayne K. | MHC signaling during social communication | The major histocompatibility complex (MHC) has been known to play a critical role in immune recognition since the 1950s. It was a surprise, then, in the 1970s when the first report appeared indicating MHC might also function in social signaling. Since this seminal discovery, MHC signaling has been f... | | 2012-01-01 |
| 335 |
 |
Linton, Matthew J. | Magnitude and mechanisms of disequilibrium between predawn plant and soil water potentials | Predawn plant water potential (Uw, measured with leaf psychrometers) and surrogate measurements made with the pressure chamber (termed Upc here) are used to infer comparative ecological performance, based on the expectation that these plant potentials reflect the wettest soil Uw accessed by roots. T... | Roots; Transpiration; Solutes | 2003 |
| 336 |
 |
Adler, Frederick R.; Feener, Donald H. | Maintaining diversity in an ant community: modeling, extending, and testing the dominance-discovery trade-off | Ant communities often consist of many species with apparently similar niches. We present a mathematical model of the dominance-discovery trade-off, the trade-off between the abilities to find and to control resources, showing that it can in principle facilitate the coexistence of large numbers of s... | Coexistence; Dominant species; Parasitoid | 2007 |
| 337 |
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Thomas, Kirk R.; Capecchi, Mario R. | Maintenance of functional equivalence during paralogous Hox gene evolution. | Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene comp... | Alleles; Animals; Cervical Vertebrae; Embryo; Genetic Complementation Test; Homeodomain Proteins; Homozygote; Mice | 2000-02-10 |
| 338 |
 |
Bohs, Lynn A. | Major clades in Solanum based on ndhF sequence data | Analysis of sequence data from the chloropiast gene ndhF identifies at least 12 major well-supported clades within the genus Solanum. These are briefly described, given informal clade names, and compared with the groups recognized by previous Solanum workers. Non-molecular synapomorphies are propos... | Solanum; ndhF | 2005 |
| 339 |
 |
Potts, Wayne K. | Major histocompatibility complex heterozygote superiority during coinfection | Genes of the major histocompatibility complex (MHC) play a critical role in immune recognition, and many alleles confer susceptibility to infectious and autoimmune diseases. How these deleterious alleles persist in populations is controversial. | Pathogen; MHC; Homozygotes | 2003 |
| 340 |
 |
Potts, Wayne K.; Granger, Donald Lee | Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice | To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is th... | MHC-congenic; Host resistance; Infection | 2003 |
| 341 |
 |
Capecchi, Mario R. | Male fertility is dependent on dipeptidase activity of testis ACE. | Testis angiotensin-converting enzyme (ACE) is an isozyme exclusively expressed by developing sperm. This protein has only a single catalytic domain containing the HEXXH consensus-site motif typical of zinc metallopeptidases. The exact role of testis ACE is unknown, but male mice lacking the protein ... | Amino Acid Motifs; Blotting, Western; Catalytic Domain; Comparative Study; Isoenzymes; Protein Structure, Tertiary | 2005-11-11 |
| 342 |
 |
Sekercioglu, Cagan | Mapping functional traits: comparing bundance and presence-absence estimates at large spatial scales | Efforts to quantify the composition of biological communities increasingly focus on functional traits. The composition of communities in terms of traits can be summarized in several ways. Ecologists are beginning to map the geographic distribution of trait-based metrics from various sources of data,... | | 2012-01-01 |
| 343 |
 |
Adler, Frederick R. | Mathematical model of a three-stage innate immune response to a pneumococcal lung infection | Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease. We combine bacterial titer measurements from mice infected with Streptococcus pneumoniae with mat... | | 2011 |
| 344 |
 |
Adler, Frederick R. | Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death | Acetaminophen is the leading cause of acute liver injury in the developed world. Timely administration of N-Acetylcysteine (N-Ac) prevents the progression of serious liver injury and disease, while failure to administer N-Ac within a critical time frame allows disease progression and in the most sev... | | 2012-01-01 |
| 345 |
 |
Beckerle, Mary C. | Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers | Actin stress fibers (SFs) in live cells consist of series of dynamic individual sarcomeric units. Within a group of consecutive SF sarcomeres, individual sarcomeres can spontaneously shorten or lengthen without changing the overall length of this group, but the underlying mechanism is unclear. We us... | | 2014-01-01 |
| 346 |
 |
Adler, Frederick R. | Mathematical modeling the age dependence of Epstein-Barr virus associated infectious mononucleosis | Most people get Epstein-Barr virus (EBV) infection at young age and are asymptomatic. Pri-mary EBV infection in adolescents and young adults however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue, and sore throat that can persist for months. Expansion in the num... | | 2012 |
| 347 |
 |
Adler, Frederick R. | Mathematical modeling the age dependence of Epstein-Barr virus associated infectious mononucleosis | Most people get Epstein-Barr virus (EBV) infection at young age and are asymptomatic. Primary EBV infection in adolescents and young adults however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue, and sore throat that can persist for months. Expansion in the numb... | | 2011 |
| 348 |
 |
Capecchi, Mario R. | Measurement of suppressor transfer RNA activity. | Transfer RNA (tRNA) suppression of nonsense mutations in prokaryotic systems has been widely used to study the structure and function of different prokaryotic genes. Through genetic engineering techniques, it is now possible to introduce suppressor (Su+) tRNA molecules into mammalian cells. A quanti... | Animals; Cells, Cultured; Eukaryotic Cells; Genes, Viral; Mice; Orthomyxoviridae; Peptide Chain Termination, Translational; Protein Biosynthesis | 1983-08-26 |
| 349 |
 |
Sekercioglu, Cagan | Measuring the meltdown: drivers of global amphibian extinction and decline | Habitat loss, climate change, over-exploitation, disease and other factors have been hypothesised in the global decline of amphibian biodiversity. However, the relative importance of and synergies among different drivers are still poorly understood. We present the largest global analysis of roughly ... | | 2008-01-01 |
| 350 |
 |
Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. Joseph | Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement | Organs and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev... | Zyxin; Actin | 2005 |
