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Creator | Title | Description | Subject | Date |
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Farmer, Colleen G. | Parental care: the key to understanding endothermy and other convergent features in birds and mammals | Birds and mammals share a number of features that are remarkably similar but that have evolved independently. One of these characters, endothermy, has been suggested to have played a cardinal role in avian and mammalian evolution. I hypothesize that it is parental care, rather than endothermy, that ... | Evolution; Metabolism; Convergence | 2000 |
| 327 |
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Hultine, Kevin | Carbon and nitrogen allocation to male and female reproduction in Rocky Mountain Douglas-fir (Pseudotsuga menziesii var. glauca, Pinaceae) | We measured carbon (respiration, photosynthesis, and production) and nitrogen allocation to male and female cones of Rocky Mountain Douglas-fir (Pseudotsuga menziesii var. glauca) to quantify gender-specific: (1) resource allocation to reproduction, and (2) contribution to carbon costs of reproducti... | Gender; photosynthesis; resource allocation | 2000 |
| 328 |
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Clayton, Dale H. | Testing species limits of non-echolocating Philippine swiftlets (Collocalia spp.) using molecular genetic data | Swiftlets are small, insectivorous birds that are distributed from the Indian Ocean, through southeast Asia and north Australia, to the Pacific. About 22 species of swiflets nest in caves or other dark places, where they navigate using a crude form of echolocation (Chantler and Driessens 1995). Thr... | | 2000 |
| 329 |
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Capecchi, Mario R. | How close are we to implementing gene targeting in animals other than the mouse? | Describes several significant contributions that bring us much closer to extending ‘‘gene targeting'' to mammalian species other than the mouse. Gene targeting now provides the means for creating new strains of mice with mutations in virtually any gene. First, the desired mutation is introduced ... | Cattle; Mutagenesis; Mice; Humans; Ethics, Medical | 2000-02-01 |
| 330 |
 |
Thomas, Kirk R.; Capecchi, Mario R. | Maintenance of functional equivalence during paralogous Hox gene evolution. | Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene comp... | Alleles; Animals; Cervical Vertebrae; Embryo; Genetic Complementation Test; Homeodomain Proteins; Homozygote; Mice | 2000-02-10 |
| 331 |
 |
Capecchi, Mario R. | Choose your target. | The technology of modifying endogenous genes has recently been extended from mice to Drosophila and sheep. Concurrently, genomic sequencing is uncovering thousands of previously uncharacterized genes. Armed with today's technologies, what are our best options for delineating the functions of these n... | Animals; Mice; Sheep | 2000-09-13 |
| 332 |
 |
Capecchi, Mario R. | Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice | While nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin levels... | ACE | 2000-10-31 |
| 333 |
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Capecchi, Mario R. | Illegitimate cre-dependent chromosome rearrangements in transgenic mouse spermatids. | The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-si... | Chromatin; Female; Mice, Inbred C57BL; Phenotype | 2000-12-05 |
| 334 |
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Moon, Ann M.; Capecchi, Mario R. | Fgf8 is required for outgrowth and patterning of the limbs. | The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep... | Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm | 2000-12-26 |
| 335 |
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Beckerle, Mary C. | Targeting of zyxin to sites of actin membrane interaction and to the nucleus | The localization of proteins to particular intracellular compartments often regulates their functions. Zyxin is a LIM protein found prominently at sites of cell adhesion, faintly in leading lamellipodia, and transiently in cell nuclei. Here we have performed a domain analysis to identify regions in ... | Zyxin; Actin; LIM domains; Focal adhesions; Lamellipodia; Cytoskeletal architecture | 2001 |
| 336 |
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| Albert Lasker Awards Ceremony, 2001 | This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h... | Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations | 2001 |
| 337 |
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Linton, Matthew J. | Hydraulic conductivity, xylem cavitation, and water potential for succulent leaves of agave deserti and agave tequilana | Axial hydraulic conductivity (Kh) was measured for fresh, dehydrated, and rehydrated leaves of the Crassulacean acid metabolism (CAM) leaf succulents, Agave deserti and Agave tequilana. Dehydration of leaves at 35(o)C for several hours caused Kh to decrease, with a 50% decrease occurring at a leaf w... | Transpiration; Dehydrated; Drought | 2001 |
| 338 |
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Olivera, Baldomero M. | On a potential global role for vitamin K-dependent γ-carboxylation in animal systems | The vitamin K-dependent γ-carboxylation of glutamate to γ-carboxyglutamate was originally well characterized in the mammalian blood clotting cascade. γ-Carboxyglutamate has also been found in a number of other mammalian proteins and in neuropeptides from the venoms of marine snails belonging to... | Carboxylation; Glutamate; Carboxyglutamate; Carboxylase mRNA; Conantokin G | 2001 |
| 339 |
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Carrier, David R. | Electromyographic pattern of the gular pump in monitor lizards | Gular pumping in monitor lizards is known to play an important role in lung ventilation, but its evolutionary origin has not yet been addressed. To determine whether the gular pump derives from the buccal pump of basal tetrapods or is a novel invention, we investigated the electromyographic activity... | Electromyographic pattern; Gular pump; Varanus exanthematicus; Lung ventilation; Evolution | 2001 |
| 340 |
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Adler, Frederick R. | Patterns of patch rejection in size-structured populations: beyond the ideal free distribution and size segregation | We examine optimal patch allocation strategies in a population structured by size or some other characteristic. By treating size-specific differences among patches as limiting factors, we create a single framework to analyse foraging for two resources, foraging in the presence of predators and fo... | Foraging-predation trade-off; Optimal foraging; Size structure | 2001 |
| 341 |
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Torti, Sylvia D.; Coley, Phyllis D.; Kursar, Thomas A. | Causes and consequences of monodominance in tropical lowland forests | Tropical canopy dominance in lowland, well-drained forests by one plant species is a long-standing conundrum in tropical biology. Research now shows that dominance is not the result of one trait or mechanism. We suggest that the striking dominance of Gilbertiodendron dewevrei in the Ituri Forest of ... | Monodominance; Gilbertiodendron dewevrei; Ituri Forest; Understory | 2001 |
| 342 |
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Seger, Jon | Evidence for a cryptic species complex in the ant parasitoid Apocephalus paraponerae (Diptera: Phoridae) | Cryptic species complexes occur in many taxa, in particular in the insect order Diptera. Here we describe a possible new cryptic species complex in the family Phoridae. Three lines of evidence suggest that Apocephalus paraponerae, an ant parasitoid, is actually a complex of at least four genetically... | Host; Sequence; Populations | 2001 |
| 343 |
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Farmer, Colleen G. | New perspective on the origin of endothermy | A new hypothesis for the origin of endothermy in birds is discussed. I suggest extensive parental care provided the initial impetus for the evolution of endothermy. Among extant animals one of the most important functions of an endothermic metabolism is the incubation of embryos. Furthermore, I prop... | Endothermy; Parental care; Thermogenesis; Reproduction; Hormone; Aerobic capacity | 2001 |
| 344 |
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Ehleringer, James R. | Sourcing drugs with stable isotopes | Carbon (δ13C) and nitrogen (δ15N) isotope ratios at natural abundance levels are useful tools in determining the region-of-origin for both cocaine and heroin. Here we show that cocaine originating from different geographic regions of South America exhibited pronounced differences in their δ13C a... | Stable isotopes; Drug sourcing; Region-of-origin signature; Isotope ratio analysis | 2001 |
| 345 |
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Shapiro, Michael D. | Cynodont from the Upper Triassic of East Greenland: tooth replacement and double-rootedness | A new genus and species of cynodont from the Upper Triassic Fleming Fjord Formation of East Greenland possesses double-rooted postcanine teeth and a nonalternate pattern of tooth replacement. The specimen represents an addition to the known diversity of Early Mesozoic taxa with multi-rooted dentitio... | Mitredon cromptoni; Cynodont; Upper Triassic; East Greenland; Fleming Fjord Formation; Tooth replacement; Double-rootedness; Multi-rooted dentition | 2001 |
| 346 |
 |
Clayton, Dale H. | Molecular phylogeny of the dove genera Streptopelia and Columba | Evolutionary history of the dove genus Streptopelia has not been examined with rigorous phylogenetic methods. We present a study of phylogenetic relationships of Streptopelia based on over 3,600 base pairs of nuclear and mitochondrial gene sequences. | Doves; Streptopelia; Columba | 2001 |
| 347 |
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Baehr, Wolfgang; Frederick, Jeanne M.; Church-Kopish, Jill; Howes, Kimberly | Mutant rhodopsin transgene expression on a null background | PURPOSE. To study mechanisms leading to photoreceptor degeneration in mouse models for autosomal dominant retinitis pigmentosa (adRP) based on the rhodopsin P23H mutation. METHODS. Mice of a transgenic line expressing a rhodopsin triple mutant, V20G, P23H, and P27L (GHL), were mated with rhodopsin (... | Mutant Rhodopsin; Photoreceptor Degeneration; Autosomal Dominant Retinitis Pigmentosa; Rhodopsin | 2001-03 |
| 348 |
 |
Davidson, Diane W. | Herbivory on planted dipterocarp seedlings in secondary logged forests and primary forests of Sabah, Malaysia | Leaf defences, leaf nutritional quality and leaf expansion rates may vary with resource availabilities to plants. Such variation could affect rates of leaf loss to herbivores, particularly along the steep resource gradients in disturbed forests. Intraspecific and interspecific variation in leaf dama... | Danum Valley; Dipterocarp; Dryobalanops lanceolata; Herbivory rates; Leaf damage; Leaf expansion rates; Logged tropical forests; Secondary forests; Shorea leprosula | 2001-03 |
| 349 |
 |
Rogers, Alan R.; Harpending, Henry C. | Genetic structure of ancient human populations | Discusses mitochondrial DNA (mtDNA) sequences as important source of data about the history of human species. | Tree of descent; Mismatch distributions; Simulations; Findings; Intermatch distributions; Younger and older populations | 2001-09-15 |
| 350 |
 |
Capecchi, Mario R. | Generating mice with targeted mutations. | Mutational analysis is one of the most informative approaches available for the study of complex biological processes. It has been particularly successful in the analysis of the biology of bacteria, yeast, the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Extension ... | Animals; Recombination, Genetic; Stem Cells | 2001-10-01 |
