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CreatorTitleDescriptionSubjectDate
301 Blumenthal, Donald K.Phosphorylation of cardiac troponin by guanosine 3':5'-monophosphate-dependent protein kinase.Homogeneous cGMP-dependent protein kinase catalyzes the rapid incorporation of phosphate, specifically into the inhibitory subunit of purified cardiac troponin with a maximal incorporation of 1 mol of phosphate/mol of troponin. When troponin was incubated in the presence of both cGMP- and cAMP-depen...Protein Kinases1978-01-25
302 Mitchell, Joyce A.A medical microcomputer database management systemThe Patient Data Handler (PDH) is a general purpose, interactive, relational database management system (DBMS) which was created to store and retrieve the patient records stemming from a research project centering upon the genetic causes and diagnosis of concomitant deafness and blindness [1, 5]. Th...1985-01-01
303 Mitchell, Joyce A.Challenges and strategies of the Genetics Home ReferenceObjective: This paper focuses on the first two years of operation of Genetics Home Reference (GHR), a Web-based resource <http://www.ghr.nlm.nih.gov> for the general public that helps to explain the health implications of findings from the Human Genome Project. Methods and Findings: Key challenges o...2006-01-01
304 Mitchell, Joyce A.Design and evaluation of a personal digital assistant-based alerting service for cliniciansPurpose: This study describes the system architecture and user acceptance of a suite of programs that deliver information about newly updated library resources to clinicians' personal digital assistants (PDAs). Description: Participants received headlines delivered to their PDAs alerting them to new...2004-01-01
305 Mitchell, Joyce A.Evidence-based retrieval in evidence-based medicineObjective: Clinical decisions based on a meta-analysis that is based on an ineffective retrieval strategy may have serious negative consequences for patients. The study objective was to investigate the extent to which meta-analyses report proof of their retrieval strategies' effectiveness. Methods: ...2004-01-01
306 Mitchell, Joyce A.Getting around in a large nomenclature file: browsing SNOMED internationalWe have developed a means whereby we can easily browse a very large (s 30 MB) file of a nomenclature vocabulary. "SNOMED International - A Vocabulary of Human and Veterinary Medicine" is such a file and has been proposed to serve as the basis for controlled vocabularies. The College of American Path...1994-01-01
307 Blumenthal, Donald K.Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.Phosphorylase kinase is a multimeric protein kinase (alpha 4 beta 4 gamma 4 delta 4) whose enzymatic activity is conferred by its gamma-subunit. A library of 18 overlapping synthetic peptides spanning residues 277-386 of the gamma-subunit has been prepared to use in identifying important regulatory ...Metabolism; Phosphorylase Kinase1995-09-22
308 Mitchell, Joyce A.Bioinformatics linkage of heterogeneous clinical and genomic information in support of personalized medicineObjectives: Biomedical Informatics as a whole faces a difficult epistemological task, since there is no foundation to explain the complexities of modeling clinical medicine and the many relationships between genotype, phenotype, and environment. This paper discusses current efforts to investigate su...2007-01-01
309 Mitchell, Joyce A.Beyond relevance--characteristics of key papers for clinicians: an exploratory study in an academic settingObjective: The purpose of this study was to determine what factors beyond relevance influence a clinician's decision to choose to read one journal article over another in satisfying an information need. Design: Seventeen health care providers were interviewed and then surveyed regarding the characte...1996-01-01
310 Mitchell, Joyce A.Construction of a medical informatics thesaurusMedical Informatics needs a specific terminology that reflects the multi-disciplinary nature of the field and can rapidly change as the discipline evolves. Using the four primary methods of thesaurus construction, a group at the University of Missouri- Columbia is developing a thesaurus that meets t...1994-01-01
311 Mitchell, Joyce A.50 Years of informatics research on decision support: what's nextObjectives: To reflect on the history, status, and future trends of decision support in health and biomedical informatics. To highlight the new challenges posed by the complexity and diversity of genomic and clinical domains. To examine the emerging paradigms for sup - porting cost-effective, person...2011-01-01
312 Mitchell, Joyce A.Computational Feature of Selection and Classification of RET Phenotypic SeverityAlthough many reported mutations in the RET oncogene have been directly associated with hereditary thyroid carcinoma, other mutations are labelled as uncertain gene variants because they have not been clearly associated with a clinical phenotype. The process of determining the severity of a mutation...2010-01-01
313 Mitchell, Joyce A.The creation and early implementation of a high speed fiber optic network for a university health sciences centerIn late 1989 the University of Missouri Health Sciences Center began the process of creating an extensive fiber optic network throughout its facilities, with the intent to provide networked computer access to anyone in the Center desiring such access, regardless of geographic location or organizatio...1991-01-01
314 Blumenthal, Donald K.Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity.Calmodulin-dependent protein phosphatase purified from bovine cardiac muscle catalyzed the rapid dephosphorylation of Ser-95 of bovine cardiac cAMP-dependent protein kinase regulatory subunit (RII). The kinetic constants determined for the reaction (Km = 20 microM; Vmax = 2 mumol min-1 mg-1) are com...Metabolism; High Pressure Liquid; Enzymology1985-06-25
315 Del Fiol, GuilhermeProviders' information needs in the care of older adults2013 Center on Aging Poster Retreat; Information needs; Clinical decision support; Electronic health record2013
316 Blumenthal, Donald K.Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase.Calmodulin-dependent protein phosphatase from bovine brain and heart was assayed for phosphotyrosine and phosphoserine phosphatase activity using several substrates: 1) smooth muscle myosin light chain (LC20) phosphorylated on tyrosine or serine residues, 2) angiotensin I phosphorylated on tyrosine,...Metabolism; Phosphatase Activity1986-07-25
317 Gardner, Reed M.Hemodynamic MonitoringBiomedical Informatics2006
318 Gardner, Reed M.Data Gathering Analysis and Display in Critical Care MedicineBiomedical Informatics1986
319 Gardner, Reed M.Evaluation of User Acceptance of a Clinical Expert SystemBiomedical Informatics1994
320 Gardner, Reed M.Fundamentals of Physiologic MonitoringBiomedical Informatics1993
321 Gardner, Reed M.The Future of Computerized Decision Support in Critical CareBiomedical Informatics1994
322 Gardner, Reed M.Digital Electronic Communications Between ICU Ventilators and Computers and PrintersBiomedical Informatics1992
323 Gardner, Reed M.Frequency of Technical Problems Encountered in the Measurement of Pulmonary Artery Wedge PressureBiomedical Informatics1984
324 Gardner, Reed M.Impact of a Clinical Information System on Hospital CostsBiomedical Informatics1986
325 Gardner, Reed M.The HELP Clinical Decision-Support SystemBiomedical Informatics1994
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