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Creator | Title | Description | Subject | Date |
| 276 |
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Rodin, Ernst A. | Interictal infraslow activity in patients with epilepsy | Objective: To evaluate if interictal infraslow activity (ISA), as obtained from a conventional EEG system, can contribute information about the epileptogenic process. Methods: The entire long-term intracranial monitoring sessions of 12 consecutive patients were evaluated on an XLTEK system for ISA. ... | | 2014-01-01 |
| 277 |
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Couldwell, William T. | Submandibular high-flow bypass in the treatment of skull base lesions: an analysis of long-term outcome | Background: Cerebral bypass surgery remains an integral part of the treatment of complex skull base tumors and unclippable aneurysms. Objective: The authors retrospectively analyzed a single-surgeon experience using a high-flow submandibular-infratemporal saphenous vein graft bypass technique after ... | | 2012-01-01 |
| 278 |
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Frederick, Jeanne M. | RNA interference gene therapy in dominant retinitis pigmentosa and cone-rod dystrophy mouse models caused by GCAP1 mutations | RNA interference (RNAi) knockdown is an efficacious therapeutic strategy for silencing genes causative for dominant retinal dystrophies. To test this, we used self-complementry (sc) AAV2/8 vector to develop an RNAi-based therapy in two dominant retinal degeneration mouse models. The allele-specific ... | | 2014-01-01 |
| 279 |
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Farrell, Timothy W. | Organizational culture associated with provider satisfaction | Background: Organizational culture is key to the successful implementation of major improvement strategies. Transformation to a patient-centered medical home (PCHM) is such an improvement strategy, requiring a shift from provider-centric care to team-based care. Because this shift may impact provide... | | 2014-01-01 |
| 280 |
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Moon, Anne M. | TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-Mammary Syndrome | TBX3 is a member of the T-box family of transcription factors with critical roles in development, oncogenesis, cell fate, and tissue homeostasis. TBX3 mutations in humans cause complex congenital malformations and Ulnar-mammary syndrome. Previous investigations into TBX3 function focused on its acti... | | 2014-01-01 |
| 281 |
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Couldwell, William T. | Intraoperative aneurysmal subarachnoid hemorrhage after rupture of a previously undiagnosed intracranial aneurysm during Chiari decompression: case report and literature review | Type 1 Chiari malformation occurs when caudal displacement of cerebellar tonsils below the level of foramen magnum obstructs the normal flow of cerebrospinal fluid (CSF) between the cranial and spinal spaces, a condition that often needs surgical decompression to restore normal CSF circulation. Abru... | | 2014-01-01 |
| 282 |
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Planelles, Vicente | Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation | Despite the clinical relevance of latent HIV-1 infection as a block to HIV-1 eradication, the molecular biology of HIV-1 latency remains incompletely understood. We recently demonstrated the presence of a gatekeeper kinase function that controls latent HIV-1 infection. Using kinase array analysis w... | | 2014-01-01 |
| 283 |
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Harris, Michael D. | Correlations between the alpha angle and femoral head asphericity: Implications and recommendations for the diagnosis of cam femoroacetabular impingement | Objective: To determine the strength of common radiographic and radial CT views for measuring true femoral head asphericity. Patients and Methods: In 15 patients with cam femoroacetabular impingement (FAI) and 15 controls, alpha angles were measured by two observers using radial CT (0º, 30º, 60º,... | | 2014-01-01 |
| 284 |
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Couldwell, William T. | Normal dimensions of the posterior pituitary bright spot on magnetic resonance imaging: Clinical article | Object. The normal pituitary bright spot seen on unenhanced T1-weighted MRI is thought to result from the T1-shortening effect of the vasopressin stored in the posterior pituitary. Individual variations in its size may be difficult to differentiate from pathological conditions resulting in either ab... | | 2014-01-01 |
| 285 |
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LaStayo, Paul C. | Intermuscular fat: a review of the consequences and causes | Muscle's structural composition is an important factor underlying muscle strength and physical function in older adults. There is an increasing amount of research to support the clear disassociation between the loss of muscle lean tissue mass and strength with aging. This disassociation implies that... | | 2014-01-01 |
| 286 |
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Kriesel, John D. | Helicase-primase inhibitor pritelivir for HSV-2 infection | Background Pritelivir, an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. We tested the efficacy and safety of pritelivir in otherwise healthy persons with genital HSV-2 infection. Methods We randomly... | | 2014-01-01 |
| 287 |
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Couldwell, William T. | Technique for methyl methacrylate cranioplasty to optimize cosmetic outcome | Background: Cranioplasty aims to reconstruct skull defects from fractures, decompressive craniectomies, tumors, and congenital anomalies in a cosmetically acceptable manner. We present a technique in methyl methacrylate cranioplasty that gives excellent cosmetic results by maintaining patient's calv... | | 2014-01-01 |
| 288 |
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Couldwell, William T. | Role of CCM1 loss-of-function-induced endothelial-to-mesenchymal transition in the development of cavernous malformations | Cerebral cavernous malformations (CCM) occur in two variants: sporadic and familial. Mutations in three genes-CCM1, CCM2, and CCM3-play a role in both subtypes, with mouse models showing the development of multiple cavernous malformations in animals with loss of function in any of these three genes.... | | 2013-01-01 |
| 289 |
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Couldwell, William T. | Surgical treatment of craniofacial fibrous dysplasia in adults | Craniofacial fibrous dysplasia is a rare disorder that may require neurosurgical expertise for definitive management; however, surgical management of FD in adult patients is uncommon. Although other therapies have been shown to slow progression, the only definitive cure for adult craniofacial FD is ... | | 2014-01-01 |
| 290 |
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Couldwell, William T. | Surgical fidelity: comparing the microscope and the endoscope | Background: Both the microscope and the endoscope are widely used as visualization tools in neurosurgery; however, surgical dexterity when operating with endoscopic visual control may differ. The aim of this study was to compare the surgical fidelity when using each of these visualization tools. Met... | | 2013-01-01 |
| 291 |
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Bernstein, Paul S. | Reflection-based imaging of macular pigment distributions in infants and children | We have developed a reflection-based capability of the RetCam® platform, an FDA-cleared pediatric retinal-imaging instrument, for the purpose of measuring macular pigment levels as well as their spatial distributions in infants and children. Our modifications include narrow-band blue-wavelength exc... | | 2013-01-01 |
| 292 |
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Dwight, Zachary Lawrence | Heterozygote PCR product melting curve prediction | Melting curve prediction of PCR products is limited to perfectly complementary strands. Multiple domains are calculated by recursive nearest-neighbor thermodynamics. However, the melting curve of an amplicon containing a heterozygous single nucleotide variant (SNV) after PCR is the composite of four... | | 2014-01-01 |
| 293 |
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Couldwell, William T. | Intracranial hypotension in the setting of concurrent perineural cyst rupture and subarachnoid hemorrhage | Although most patients with intracranial hypotension typically present with headaches, the rest of the clinical spectrum is characteristically non-specific and often quite variable. In a patient with concurrent pathologies that can produce a similar clinical picture, a high index of suspicion must b... | | 2013-01-01 |
| 294 |
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Narus, Scott P. | Improving access to longitudinal patient health information within an emergency department | We designed and implemented an electronic patient tracking system with improved user authentication and patient selection. We then measured access to clinical information from previous clinical encounters before and after implementation of the system. Clinicians accessed longitudinal information for... | | 2012-01-01 |
| 295 |
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Mitchell, Joyce A. | Assessing clinical researchers information needs to create responsive portals and tools: my research assistant (MyRA) at the University of Utah: a case study | Question: How can health sciences librarians and biomedical informaticians offer relevant support to Clinical and Translational Science Award (CTSA) personnel? Setting: The Spencer S. Eccles Health Sciences Library and the associate vice president for information technology for the health sciences o... | | 2013-01-01 |
| 296 |
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Dwight, Zachary Lawrence | uAnalyze: web-based high-resolution DNA melting analysis with comparison to thermodynamic predictions | Abstract-uAnalyzeSM is a web-based tool for analyzing high-resolution melting data of PCR products. PCR product sequence is input by the user and recursive nearest neighbor thermodynamic calculations used to predict a melting curve similar to uMELT (http://www.dna.utah.edu/umelt/umelt.html). Unproce... | | 2012-01-01 |
| 297 |
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Crockett, David K. | Identification of histoplasma -specific peptides in human urine | Histoplasmosis is a severe dimorphic fungus infection, which is often difficult to diagnose due to similarity in symptoms to other diseases and lack of specific diagnostic tests. Urine samples from histoplasma-antigen-positive patients and appropriate controls were prepared using various sample prep... | | 2012-01-01 |
| 298 |
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Bernstein, Paul S. | Skin carotenoid status measured by resonance Raman spectroscopy as a biomarker of fruit and vegetable intake in preschool children | Background/Objective: Dietary assessment in children is difficult, suggesting a need to develop more objective biomarkers of intake. Resonance Raman spectroscopy (RRS) is a noninvasive, validated method of measuring carotenoid status in skin as a biomarker of fruit/vegetable intake. The purpose of t... | | 2012-01-01 |
| 299 |
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Farrell, Timothy W. | The state of care transitions education: A survey of AGS teachers section members | Care transitions pose significant risks for older and more complex medical patients, including medication errors and rehospitalizations. Unfortunately, few medical schools and residency programs provide targeted care transitions training. Changes in the healthcare system, including coordination of c... | 2013 AGS Posters, AGS, care transitions, geriatrics education | 2013 |
| 300 |
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Jensen, Randy Lynn | Treatment-related brain tumor imaging changes: so-called "pseudoprogression" vs. tumor progression: Review and future research opportunities | Background: Glioblastoma multiforme (GBM) has a dismal prognosis despite aggressive therapy. Initial diagnosis and measurement of response to treatment is usually determined by measurement of gadolinium-enhanced tumor volume with magnetic resonance imaging (MRI). Unfortunately, many GBM treatment mo... | | 2013-01-01 |
