UScholar Works
 
Filters: Department: "Biology" Collection: "ir_uspace"
276 - 300 of 649
Number of results to display per page
CreatorTitleDescriptionSubjectDate
276 Capecchi, Mario R.; Tvrdik, PetrHoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry.Formation of neuronal circuits in the head requires the coordinated development of neurons within the central nervous system (CNS) and neural crest-derived peripheral target tissues. Hoxb1, which is expressed throughout rhombomere 4 (r4), has been shown to be required for the specification of facial...Rhombomere 4; Branchiomotor; Cranial Nerve2004-07-04
277 Capecchi, Mario R.Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebraeTo address the expression and function of Hoxb13, the 5' most Hox gene in the HoxB cluster, we have generated mice with loss-of-function and beta-galactosidase reporter insertion alleles of this gene. Mice homozygous for Hoxb13 loss-of-function mutations show overgrowth in all major structures deriv...Animals; Axons; Ganglia, Spinal; Mice; Spinal Cord2003-04-15
278 Capecchi, Mario R.Hoxb8 is required for normal grooming behavior in mice.Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Add...Aging; Alleles; Animals, Newborn; Behavior, Animal; Bone and Bones; Disease Models, Animal; Mice, Knockout Nerve Net2002-01-03
279 Capecchi, Mario R.Hoxc13 mutant mice lack external hairHox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibri...Filiform papillae; Homozygotes; Paralogous1998-01-01
280 Carrier, David R.Human flight and exercise in microgravityEarly experimenters in human flight learned, sometimes with fatal consequences, that the human body lacks the muscular power to fly (1). Indeed, the power demands are so great that only relatively small animals (less than 12 kg) are able to fly actively due to the interplay of morphologic scaling (m...Human flight; Microgravity2000
281 Baehr, WolfgangHuman interstitial retinoid-binding protein. Gene structure and primary structureInterstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ...Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA1989-05-15
282 Sperry, John S.Hydraulic architecture of palmsThe water transport and storage system of palms is adapted to maintain the primary stem xylem functional over the life of the shoot, and in spite of severe drought. However, our structural information far exceeds our knowledge of vascular function, and these functional considerations bring more que...Hydraulic architecture; Rhapis excelsa; Cavitation1995
283 Linton, Matthew J.Hydraulic conductivity, xylem cavitation, and water potential for succulent leaves of agave deserti and agave tequilanaAxial hydraulic conductivity (Kh) was measured for fresh, dehydrated, and rehydrated leaves of the Crassulacean acid metabolism (CAM) leaf succulents, Agave deserti and Agave tequilana. Dehydration of leaves at 35(o)C for several hours caused Kh to decrease, with a 50% decrease occurring at a leaf w...Transpiration; Dehydrated; Drought2001
284 Sperry, John S.Hydraulic consequences of vessel evolution in angiospermsWe tested two hypotheses for how vessel evolution in angiosperms influenced xylem function. First, the transition to vessels decreased resistance to flow--often considered the driving force for their evolution. Second, the transition to vessels compromised safety from cavitation--a constraint emergi...Cavitation; Resistivity; Perforation2007
285 Sekercioglu, CaganIbis questThe day I arrived in Ethiopia, researcher Yilma Dellelegn Abebe of the Ethiopia Wildlife and Natural History Society (EWNHS) was just leaving the capital city, Addis Ababa, to search for three Northern Bald Ibises in a remote, roadless area of the country. These critically endangered birds had been ...2007-01-01
286 Seger, JonIdeas in ecologyThe word "ecology" means different things to different people. For example, during the last 25 years or so the word has been used to label attitudes, life-styles, consumer goods, political parties, and college courses. In the 1960s one university renamed its "Home Economics" course "Home Ecology."...Behavioral ecology; Population ecology1986
287 Olivera, Baldomero M.Identification and characterization of a Ca2+-sensitive nonspecific cation channel underlying prolonged repetitive firing in Aplysia neuronsThe afterdischarge of Aplysia bag cell neurons has served as a model system for the study of phosphorylation-mediated changes in neuronal excitability. The nature of the depolarization generating the afterdischarge, however, has remained unclear. We now have found that venom from Conus textile trig...Ca21-activated nonspecific cation channel; Slow inward current; Ion channel modulation; Afterdischarge; Bursting; Aplysia bag cell neurons; Conus textile; Neurotoxins1996
288 Beckerle, Mary C.Identification of a new protein localized at sites of cell-substrate adhesionA new protein found at sites of cellsubstrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells.Actin; Nonimmune rabbit serum; Polypeptide1986
289 Olivera, Baldomero M.Identification of a novel pharmacophore for peptide toxins interacting with K+ channelsқM-conotoxin RIIIK blocks TSha1 K+ channels from trout with high affinity by interacting with the ion channel pore. As opposed to many other peptides targeting K+ channels, қM-RIIIK does not possess a functional dyad. In this study we combine thermodynamic mutant cycle analysis and docking calc...Conotoxins; Peptide toxins; қM-conotoxin RIIIK; Pharmacophore2005
290 Olivera, Baldomero M.Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxinsPeptidylprolyl cis-trans isomerases (PPIases) are ubiquitous proteins that catalyze the cis-trans isomerization of prolines. A number of proteins, such as Drosophila rhodopsin and the human immunodeficiency viral protein HIV-1 Gag, have been identified as endogenous substrates for PPIases. However, ...2010
291 Capecchi, Mario R.Illegitimate cre-dependent chromosome rearrangements in transgenic mouse spermatids.The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-si...Chromatin; Female; Mice, Inbred C57BL; Phenotype2000-12-05
292 Bowling, David R.Impacts of anthropogenic emissions and cold air pools on urban to montane gradients of snowpack ion concentrations in the Wasatch Mountains, UtahUrban montane valleys are often characterized by periodic wintertime temperature inversions (cold air pools) that increase atmospheric particulate matter concentrations, potentially stimulating the deposition of major ions to these snow-covered ecosystems. We assessed spatial and temporal patterns o...2014-01-01
293 Sekercioglu, CaganImpacts of birdwatching on human and avian communitiesEcotourism can be a vehicle for community-based conservation if it is conducted with an emphasis on the well-being of local ecosystems and human communities. Birdwatchers form the largest group of ecotourists, and are, on average, well-educated, wealthy and committed. This makes them ideal ecotouris...2002-01-01
294 Ehleringer, James R.Implications of CO2 pooling on δ13C of ecosystem respiration and leaves in Amazonian forestThe carbon isotope of a leaf (δ13Cleaf) is generally more negative in riparian zones than in areas with low soil moisture content or rainfall input. In Central Amazonia, the small-scale topography is composed of plateaus and valleys, with plateaus generally having a lower soil moisture status ...Amazonia; Carbon dioxide; Oxygen isotope ratio; Respiration; Soil water content2008
295 Varner, Johanna; Dearing, Denise M.The importance of biologically relevant microclimates in species distribution models and habitat suitability assessmentsPredicting habitat suitability under climate change is vital to conserving biodiversity. However, current species distribution models rely on coarse scale climate data, whereas fine scale microclimate data may be necessary to assess habitat suitability and generate predictive models. Here, we evalua...2013
296 Sekercioglu, CaganImportance of Ethiopian shade coffee farms for forest bird conservationCoffee is the most important tropical commodity and is grown in high-priority areas for biological conservation. There is abundant literature on the conservation value of coffee farms internationally, but there has been little research on this topic in Africa. Ethiopia is a diverse and little-studie...2014-01-01
297 Jorgensen, ErikImproved Mos1-mediated transgenesis in C. elegansThe ability to add or delete genes to the genome of genetic model organisms is essential. Previously, we developed methods based on the Mos1 transposon1 to make targeted transgene insertions (Mos1-mediated Single Copy transgene Insertions, MosSCI2) and targeted deletions (Mos1-mediated deletions, Mo...2012-01-01
298 Capecchi, Mario R.In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells.Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for future therapies based on cell replacement. The isolation of defined cell populations from a certain lineage or tissue is a prerequisite for the analysis of the potent...Animals; Cell Differentiation; Cells, Cultured; Gene Transfer Techniques; Mice, Transgenic2005-10-23
299 Loftus, Patrick David; Rosenblatt, Jody; Eisenhoffer Jr., George ThomasInduced pressure promotes extrusion and transient polyp formation in MDCK monolayers to maintain homeostasisIn the human body about 100,000 cells are produced every second by mitosis and a similar number die by apoptosis. What happens if too much death occurs? What happens if too little death occurs? How are dying epithelial cells removed?Extrusion; MDCK monolayers; Polyp formation; Trapeze Interactive Poster2010-03-15
300 Potts, Wayne K.Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals?Congenic strains of mice are assumed to differ only at a single gene or region of the genome. These mice have great importance in evaluating the function of genes. However, their utility depends on the maintenance of this true congenic nature. Although, accumulating evidence suggests that congenic ...Strains; Mutations; Pathogen2004
276 - 300 of 649