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Creator | Title | Description | Subject | Date |
251 |
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Capecchi, Mario R.; Mansour, Suzanne L.; Thomas, Kirk R. | Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. | Gene targeting--homologous recombination of DNA sequences residing in the chromosome with newly introduced DNA sequences--in mouse embryo-derived stem cells promises to provide a means to generate mice of any desired genotype. We describe a positive nd negative selection procedure that enriches 2,00... | Animals; Clone Cells; Restriction Mapping; Stem Cells | 1988-11-24 |
252 |
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Warner, Homer R. | An Approach to Evaluating the Completeness of a Medical Knowledge Base | Biomedical Informatics | | 1989 |
253 |
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Warner, Homer R. | The HELP System Development Tools | Biomedical Informatics | | 1989 |
254 |
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Warner, Homer R. | Revision of Diagnostic Logic Using a Clinical Database | Biomedical Informatics | | 1989 |
255 |
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Warner, Homer R. | Data Driven Interpretation of Laboratory Results in the Context of a Medical Decision Support System | Biomedical Informatics | | 1989 |
256 |
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Warner, Homer R. | Database Capture of Natural Language Echocardiographic Reports: A Unified Medical Language System Approach | Biomedical Informatics | | 1989 |
257 |
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Warner, Homer R. | Passing Partial Information among Bayesean and Boolean Frames | Biomedical Informatics | | 1989 |
258 |
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Baehr, Wolfgang | Cloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strains | We cloned and sequenced the gene encoding the major outer membrane protein (MOMP) of two Chlamydia psittaci strains, guinea pig inclusion conjunctivitis (GPIC) strain 1, and meningopneumonitis (Mn) strain Cal-10. Intraspecies alignment of the two C. psittaci MOMP genes revealed 80.6% similarity, and... | Base Sequence; Cloning, Molecular; Amino Acid Sequence | 1989 |
259 |
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Normann, Richard A.; Kolb, Helga; Lasater, Eric M. | Signal integration at the pedicle of turtle cone photoreceptors: an anatomical and electrophysiological study | The morphology of the axon which connects the cell body and pedicle of turtle cone photoreceptors was studied by light and electron microscopy. The axon which contains numerous synaptic vesicles, some endoplasmic reticulum, and a few cisternae is basically filled with cytoplasm. The length of the ax... | Cone Photoreceptor, Voltage Clamp; Isolated Cells; Input Resistance; Cell Body-Pedicle Coupling | 1989 |
260 |
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Warner, Homer R. | Clustered Disease Findings: Aspects of Experts Systems | Biomedical Informatics | | 1989 |
261 |
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Warner, Homer R. | ILIAD as a Patient Case Simulator to Teach Medical Problem Solving | Biomedical Informatics | | 1989 |
262 |
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Couldwell, William T. | Management of cysticercosis cerebri | Infestation of the central nervous system (CNS) with the parasitic larval form of the cestode Taenia solium, Cysticercosis Cerebri represents an endemic problem in much of the underdeveloped world. In such areas, up to 4% of the population maybe affected by neurocysticercosis, and it accounts for u... | Taenia solium; Cysticercosis Cerebri; Parenchymal cyst; Basilar cisternal cyst; Intraventricular cyst | 1989 |
263 |
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Couldwell, William T. | Pituitary gland metastasis from adenocarcinoma of the prostate | A case of prostatic carcinoma metastasis to the pituitary gland is reported. The presentation and rarity of such a lesion is addressed. The literature review yielded only isolated case reports of symptomatic brain metastases unassociated with bone disease from adenocarcinoma of the prostate. The man... | Prostate; Pituitary gland; Adenocarcinoma; Metastasis; Transsphenoidal surgery | 1989 |
264 |
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Angelucci, Alessandra | Segregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis. | The spatial relations between selected classes of association and callosal neurons were studied in the frontal and parietal lobes of the macaque monkey using retrogradely transported fluorescent dyes. Fast blue and nuclear yellow were injected in the left frontal (areas 4 and 6) and right posterior ... | Macaca fascicularis; Parietal Lobe; Neurons | 1989 |
265 |
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Gardner, Reed M. | Improved Perioperative Antibiotic Use and Reduced Surgical Wound Infection Through Use of Computer Decision Analysis | Biomedical Informatics | | 1989 |
266 |
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Gardner, Reed M. | Pulmonary Function Laboratory Standards | Biomedical Informatics | | 1989 |
267 |
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Kestle, John R. W. | Intervertebral disc embolization resulting in spinal cord infarction | A case of spinal cord infarction resulting from embolization of fibrocartilaginous intervertebral disc material is presented. Cases from the literature are reviewed and the theories of pathogenesis are discussed. In all reported cases the diagnosis was not made until postmortem examination. | Spinal cord infarction; Nucleus pulposus; Intervertebral disc; Embolization | 1989 |
268 |
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Digre, Kathleen B. | Significance of CT and MR findings in sphenoid sinus disease. | Disorders of the paranasal sinuses, particularly the sphenoid sinus, can be associated with significant disorders of the optic and other cranial nerves. We examined 100 consecutive routine CT scans, 100 posterior fossa CT scans, and 100 MR scans to look for evidence of sinus disease, especially of t... | Sphenoid Sinus; Vision Disorders; Paranasal Sinus Diseases; Magnetic Resonance Imaging | 1989-05 |
269 |
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Blumenthal, Donald K. | Effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding. | Using site-directed mutagenesis we have expressed in Escherichia coli three engineered calmodulins (CaM) containing deletions in the solvent-exposed region of the central helix. These are CaM delta 84, Glu-84 removed; CaM delta 83-84, Glu-83 and Glu-84 removed; and CaM delta 81-84, Ser-81 through Gl... | Drug Effects; Genetics; Metabolism | 1989-05-15 |
270 |
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Baehr, Wolfgang | Human interstitial retinoid-binding protein. Gene structure and primary structure | Interstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ... | Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA | 1989-05-15 |
271 |
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Blumenthal, Donald K. | Gamma-subunit of skeletal muscle phosphorylase kinase contains two noncontiguous domains that act in concert to bind calmodulin. | Phosphorylase kinase is a Ca2+-regulated, multisubunit enzyme that contains calmodulin as an integral subunit (termed the delta-subunit). Ca2+-dependent activity of the enzyme is thought to be regulated by direct interaction of the delta-subunit with the catalytic subunit (the gamma-subunit) in the ... | Pharmacology; Metabolism; Enzymology | 1989-10-15 |
272 |
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Warner, Homer R. | Some Changes in Medical Informatics (Editorial) | Biomedical Informatics | | 1990 |
273 |
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Normann, Richard A. | Background and bleaching adaptation in luminosity type horizontal cells in the isolated turtle retina | 1. The effects of background illumination and bleached photopigment on luminosity type horizontal cells were studied in the isolated turtle retina. 2. Background illumination, which produced less than 60% bleaching, hyperpolarized and desensitized the horizontal cells to a degree which depended upon... | Turtles; Retina; Photoreceptors; Bleached photopigment; Dark Adaptation | 1990 |
274 |
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Warner, Homer R. | History of Medical Informatics at Utah | Biomedical Informatics | | 1990 |
275 |
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Warner, Homer R. | Toward a Public Domain UMLS Patient Database | Biomedical Informatics | | 1990 |