UScholar Works
 
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CreatorTitleDescriptionSubjectDate
251 Fleming Aaron M.Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoinOxidation of the guanine heterocycle by two electrons can yield the chiral product 5-carboxamido-5-formamido-2-iminohydantoin (2Ih). The 2Ih free base enantiomers were synthesized from 2'-deoxyguanosine oxidized with a Cu(II)/H2O2 oxidant system followed by hydrolysis of the N-glycosidic bond. These...Guanine oxidation; 2-Iminohydantoin; Electronic circular dichroism; Time-dependent density functional theory2014-12-15
252 Olivera, Baldomero M.; Parks, Thomas N.Conantokin-T: a γ-carboxyglutamate containing peptide with N-methyl-D-aspartate antagonist activityConantokin-T, a 21-amino acid peptide which induces sleep-like symptoms in young mice was purified from the venom of the fish-hunting cone snail, Conus tulipa. The amino acid sequence of the peptide was determined and verified by chemical synthesis. The peptide has 4 residues of the modified amino ...Conotoxins; Conantokin-T; N-methyl-D-aspartate antagonist; Conus tulipa1990
253 Seger, JonConditional relatedness, recombination, and the chromosome numbers of insectsIf two polymorphic loci are out of phase equilibrium, a homozygote at one of these loci is more highly related to its kin, at the other locus, than is an equivalent heterozygote. As a result, selection can favor (1) phenotypic responses to relative heterozygosity, and (2) increased recombination bet...Coefficients of relatedness; Conditional relatedness1983
254 Mattis, Daniel C.Conductivity of one-dimensional interacting fermions*Using an exactly soluble model, the decay rate of a current-carrying state of one-dimensional fermions is calculated in the presence of random scatterers at finite temperature and the dc conductivity thereby inferred. For interacting fermions it is modified by a factor (T/T + θ)g, where g is a posi...Fermi gas1974-04
255 Vardeny, Zeev ValentineConfined and delocalized polarons in ∏-conjugated oligomers and polymers: a study of the effective conjugation lengthWe studied optical absorption of polarons in ∏-conjugated oligomers and polymers using the photoinduced absorption technique as well as chemical doping spectra from the literature. We find that the photon energy of the polaron low-energy transition obeys a relationship that depends only on the oli...Confined polarons; Delocalized polarons; pi-conjugated oligomers; pi-conjugated polymers; Effective conjugation length2004-06
256 Blumenthal, Donald K.; Trewhella, JillConformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.Different isoforms of the full-length protein kinase A (PKA) regulatory subunit homodimer (R2) and the catalytic (C) subunit-bound holoenzyme (R2C2) have very different global structures despite similar molecular weights and domain organization within their primary sequences. To date, it has been th...Protein Isoforms; Global Structures; cAMP2005-10-21
257 DeTar, CarletonConjecture concerning the modes of excitation of the quark-gluon plasmaIt is a widely held belief that at temperatures much higher than the confinement scale of quantumchromodynamics (QCD), quarks and gluons become free, giving rise to a new form of matter, called the quark-gluon plasma. It is conjectured here that the characterization of the plasma as a free or weakl...Polyakov loops; Excitation1985-07
258 Vardeny, Zeev ValentineConjugation-length dependence of spin-dependent excition formations rates in ∏-conjugated oligomers and polymersWe have measured the ratio, r =ơ s/ơT of the formation cross section, ơ of singlet and triplet excitons from polarons in ∏-conjugated oligomer and polymer films, using a spectroscopic technique we developed recently. We discovered a universal relation between r and the conjugation length (CL): ...pi-conjugated polymers; Conjugation length; Polaron recombination2002-04
259 Olivera, Baldomero M.Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magusWe describe the purification and first biochemical characterization of an enzymatic activity in venom from the marine snail Conus magus. This enzyme, named conodipine-M, is a novel phospholipase A2 with a molecular mass of 13.6 ĸDa and is comprised of two polypeptide chains linked by one or more di...Conotoxins; Conodipine-M; Conus magus1994
260 Olivera, Baldomero M.; Gray, William RobertConotoxin MI: disulfide bonding and conformational statesThe toxic peptide from Conus magus venom (conotoxin MI) is a 14-amino acid peptide (McIntosh, M., Cruz, L. J., Hunkapiller, M. W., Gray, W. R., and Olivera, B. M. (1982) Arch. Biochem. Biophys. 218, 329-334) which inhibits the acetylcholine ceptor. In this work we have confirmed the primary structu...Conotoxins; Disulfide bonding; Venom; Conus magus1983
261 Olivera, Baldomero M.; Hillyard, David R.ConotoxinsMany successful animal and plant families have developed distinctive biochemical strategies; one of the more unusual examples is found in a group of marine gastropods, the cone snails (Conus) (1). These animals have evolved a specialized biochemistry of small constrained peptides, the conotoxins. Th...Conotoxins1991
262 Potts, Wayne K.Consequences of self and foreign superantigen interaction with specific VB elements of the murine TCR aBThe aB T-cell receptor (TCRaB) recognizes a ligand composed of an antigen fragment complexed with a product of the major histocompatibility complex (MHC). The repertoire of receptors is limited both by the germ line of receptor variable elements and by selective events that take place during T-cell ...Toxins; Repertoire; Expression1989
263 Beckerle, Mary C.; Clark, Kathleen A.Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegansWe describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula...LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development1999
264 Yang, Seung OokConstruction of a protein-based nanoreactor using charge complementarity2012
265 Adler, Frederick R.Construction of multidimensional clustered patternsEcological processes often depend upon the patterning, as well as the absolute density, of resources. In this paper, we develop methods for describing pattern from the perspective of the organism encountering and exploiting the resources, and for reconstructing pattern from the description.Algorithms; clustered resources; foraging1994
266 Symko, Orest GeorgeContinuously operating 4He evaporation refrigeratorA simple and compact device was developed to provide continuous, self-regulating refrigeration at approximately 1.3 K. The temperature of the device remains nearly constant, independent of external power, up to a critical power. For a molar flow rate of 10^-4 moles/sec, the refrigerator can absorb...4He evaporation refrigerator1971
267 DeTar, CarletonContinuum limit in the quenched approximationPrevious work at G/g2 = 5.7 with quenched staggered quarks is extended with new calculations at 5.85 and 6.15 on lattices up to 323 x 64. These calculations allow a more detailed study of extrapolation in quark mass, finite volume and lattice spacing than has heretofore been possible. We discuss h...Decay constants; Staggered quarks; Wilson quarks1996-03
268 DeTar, CarletonContinuum limit of lattice QCD with staggered quarks in the quenched approximation: a critical role for the chiral extrapolationWe calculate the light quark spectrum of lattice QCD in the quenched approximation using staggered quarks. We take the light quark mass, infinite volume, continuum limit. With nonlinear chiral extrapolations, we find that the nucleon to p mass ratio is mN/mp =­ 1.254 + 0.018 + 0.028, where the err...Staggered quarks; Chiral extrapolations1998-10
269 Goller, FranzContributions of expiratory muscles to song production in zebra finchesBirdsong production requires coordinated activity of syringeal and respiratory muscles, Phonation occurs during the expiratory phase of the respiratory cycle, and expiratory muscles generate the pressure head for sound production.Phonation; Syringeal muscles; Air sac pressure1999
270 Lupton, John MarkControl of mobility in molecular organic semiconductors by dendrimer generationConjugated dendrimers are of interest as novel materials for light-emitting diodes. They consist of a luminescent chromophore at the core with highly branched conjugated dendron sidegroups. In these materials, light emission occurs from the core and is independent of generation. The dendron branchin...Dendrimer generation; Dendron branching; Charge transport; Mobility2001-03
271 Minteer, Shelley D.Controlled placement of enzymes on carbon nanotubes using comb-branched DNAImmobilization is not only useful for preserving enzyme activity, but also to adhere an enzyme to a surface, such as an electrode, so that the enzyme does not leach into solution during testing. Current immobilization approaches do not readily allow for adjustments to the distance between the enzyme...2014-01-01
272 Olivera, Baldomero M.; Gray, William RobertContryphan is a D-tryptophan-containing Conus peptideIn this report, we document for the first time the occurrence of D-tryptophan in a normally translated polypeptide, contryphan. The peptide, isolated from the venom of the fish-hunting marine snail Conus radiatus, produces the "stiff-tail" syndrome in mice.Conotoxins; Contryphan; D-tryptophan; Conus peptides; Conus radiatus; Stiff-tail syndrome1996
273 Olivera, Baldomero M.; Gray, William Robert; Yoshikami, DojuConus geographus toxins that discriminate between neuronal and muscle sodium channelsWe describe the properties of a family of 22-amino acid peptides, the μ-conotoxins, which are useful probes for investigating voltage-dependent sodium channels of excitable tissues. The μ-conotoxins are present in the venom of the piscivorous marine snail, Conus geographus L. We have purified even...Conus geographus; Venom; Conotoxins; Sodium channels; Neurotoxins1985
274 Olivera, Baldomero M.; McIntosh, J. MichaelConus peptides as tools for the neuroscientistRecombinant DNA technology has had a powerful impact on understanding receptors and ion channels, the key components in the nervous system that are involved in intercellular communication. Cloning genes encoding these proteins has revealed that for every receptor and ion channel type, multiple molec...Conus peptides; Conotoxins1993
275 Olivera, Baldomero M.Conus peptides: biodiversity-based discovery and exogenomicsThe venoms of the ~700 species of predatory cone snails (genus Conus) are being systematically characterized. Each Conus species contains 100-200 small, highly structured venom peptides (colloquially known as conotoxins), which are synthesized and secreted in a venom duct (for overviews, see Refs. ...Conotoxins; Conus peptides; Exogenomics2006
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