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Creator | Title | Description | Subject | Date |
| 251 |
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Capecchi, Mario R. | Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. | Mice were generated with a targeted disruption of the homeobox-containing gene hoxb-9. Mice homozygous for this mutation show defects in the development of the first and second ribs. In most cases the first and second ribs are fused near the point at which the first and second pairs of ribs normally... | Embryonic and Fetal Development; In Situ Hybridization; Mice, Knockout | 1997-01-15 |
| 252 |
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Capecchi, Mario R. | Critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice | Angiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used ta... | Blood pressure; ACE activity; Enzyme | 1997-03-06 |
| 253 |
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Capecchi, Mario R. | Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. | The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA rec... | Animals, Newborn; Crosses, Genetic | 1997-10-14 |
| 254 |
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| KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997 | This 3 minutes, 1 second video clip from Salt Lake City's KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human diseases. | Gene targeting; Genetic engineering; Molecular genetics; Cancer Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Television feature stories | 1997-11-09 |
| 255 |
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Capecchi, Mario R. | Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. | Hox genes encode transcription factors that are used to regionalize the mammalian embryo. Analysis of mice carrying targeted mutations in individual and multiple Hox genes is beginning to reveal a complex network of interactions among these closely related genes which is responsible for directing th... | Abnormalities, Multiple; Gene Targeting; Glossopharyngeal Nerve; Mice, Knockout; Morphogenesis | 1997-12-15 |
| 256 |
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Olivera, Baldomero M.; Hillyard, David R.; Gray, William Robert | ĸ-Conotoxin PVIIA is a peptide inhibiting the Shaker K+ channel | ĸ-Conotoxin PVIIA (k-PVIIA), a 27-amino acid toxin from Conus purpurascens venom that inhibits the Shaker potassium channel, was chemically synthesized in a biologically active form. The disulfide connectivity of the peptide was determined. ĸ-Conotoxin PVIIA has the following structure. | Conotoxins; k-Conotoxin PVIIA; Conus purpurascens | 1998 |
| 257 |
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Ehleringer, James R. | Carbon isotope dynamics in Abies amabilis stands in the Cascades | Carbon isotope ratios (d13C) of canopy air and carbon isotope discrimination at the ecosystem level were studied in three montane Pacific silver fir (Abies amabilis (Dougl. ex Loud.) Dougl. ex J. Forbes) stands, an old-growth and two younger stands. Spatial and temporal variations of canopy CO2 con... | Carbon isotopes; Pacific silver fir; Carbon budget; Soil respiration; Cascade Mountains | 1998 |
| 258 |
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Capecchi, Mario R. | Gene targeting: an historical perspective | Our entry into what was going to become the field of gene targeting began in 1977. I was experimenting with the use of extremely small glass needles to inject DNA directly into the nuclei of living cells. The needles were controlled by hydraulically driven micro-manipulators and were directed into n... | Gene targeting -- History; Homologous recombination | 1998 |
| 259 |
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| AAMC Award for Distinguished Research presentation for 1998 | This is a 3 minutes, 51 seconds video of the presentation of the American Association of Medical Colleges' Award for Distinguished Research to Mario Capecchi and Oliver Smithies for their independent work as pioneers in gene targeting. | Transgenic mice; Gene targeting; Genetic engineering; Mutagenesis; Capecchi, Mario R.; Science - Awards - United States; Smithies, Oliver; Awards presentations | 1998 |
| 260 |
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Olivera, Baldomero M.; ; McIntosh, J. Michael | α-Conotoxin AuIB selective blocks α3ß4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release | Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3ß4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally. However, progress in the characterization of... | Conotoxins; a-Conotoxin AuIB; Norepinephrine release | 1998 |
| 261 |
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Hughes, Kelly T. | Flagellar anti-σ factor FlgM actively dissociates Salmonella typhimurium σ28 RNA polymerase holoenzyme | The anti-σ factor FlgM of Salmonella typhimurium inhibits transcription of class 3 flagellar genes through a direct interaction with the flagellar-specific σ factor, σ28. FlgM is believed to prevent RNA polymerase (RNAP) holoenzyme formation by sequestering free σ28. We have analyzed FlgM-media... | sigma-factors; transcription; FlgM; Flagellum | 1998 |
| 262 |
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| Genetics in Utah : NPR talk of the nation, science Friday for May 15, 1998 | This is a 1 hour, 9 seconds audio transcript of National Public Radio's Science Friday that was taped at Westminster College of Salt Lake on 1998/05/15. The host, Ira Flatow, leads a panel composed of University of Utah scientists and researchers, Jeffrey Bodkin, Mario Capecchi, Ray Gesteland, Mark... | Genetic engineering; Molecular genetics; Capecchi, Mario R.; Homeobox genes; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis | 1998 |
| 263 |
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Olivera, Baldomero M.; Gray, William Robert; Hillyard, David R. | μ-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes | We report the characterization of a new sodium channel blocker, m-conotoxin PIIIA (m-PIIIA). The peptide has been synthesized chemically and its disulfide bridging pattern determined. | Conotoxins; m-Conotoxin PIIIA; Sodium channel blockers | 1998 |
| 264 |
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Ehleringer, James R. | Carbon isotope ratios of Atacama Desert plants reflect hyperaridity of region in northern Chile | Leaf carbon isotope ratios were measured on plants from the coastal portions of the Atacama Desert at Pan de Azucar and Paposo, Chile. Most species possessed C3 photosynthesis, although there were several CAM species, indications of some facultative CAM species, and only one C4 species. The carbon i... | Atacama Desert; Carbon isotope ratio; Intercellular carbon dioxide concentration; Hyperaridity | 1998 |
| 265 |
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Ehleringer, James R. | Responses of boreal conifers to climate fluctuations: indications from tree-ring widths and carbon isotope analyses | Spatial distribution and species composition of the boreal forest are expected to change under predicted climate change scenarios. Current research indicates that water limitations control the southern boundary of the central Canadian boreal forest and temperature limitations control the northern b... | Boreal forests; Carbon budget; Picea mariana; Pinus banksiana; Carbon isotopes | 1998 |
| 266 |
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Davidson, Diane W. | Nonnative brome grasses in the new national monument | Included within the boundaries of the Grand-Staircase Escalante National Monument are a number of noxious weeds for which the BLM mandates control. In addition to listed weeds are nonnative brome grasses [Bromus tectorum and Bromus rubens), which can potentially convert native ecosystems to biologic... | Noxious weeds, Cheatgrass, | 1998 |
| 267 |
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Beckerle, Mary C. | Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains | Drosophila Enabled (Ena) was initially identified as a dominant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member of the Ena/human vasodilator-stimulated phosphoprotein (VASP) family of proteins. We have used genetic, biochemical, and cell biological appr... | Drosophila Ena; VASP | 1998 |
| 268 |
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Gesteland, Raymond F.; Atkins, John F.; Ingram, Jennifer A.; Kelly, Paul J.; Grentzmann, Guido | Dual-luciferase reporter system for studying recoding signals | A new reporter system has been developed for measuring translation coupling efficiency of recoding mechanisms such as frameshifting or readthrough. A recoding test sequence is cloned in between the renilla and firefly luciferase reporter genes and the two luciferase activities are subsequently measu... | Amino Acid Sequence; Genes, Reporter; HIV; Antizyme; Translation | 1998 |
| 269 |
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Davidson, Diane W. | Effects of trenching on growth and survival of planted Shorea parvifolia seedlings under pioneer stands in a logged-over forest | Effects of trenching on growth and survival of planted Shorea parvifolia seedlings under pioneer stands in a logged-over forest. We conducted an experiment to determine the value of trenching in reducing potentially negative effects of root competition on growth of Shorea parvifolia seedlings plant... | Shorea parvifolia; Trenching; Dipterocarp seedlings; Enrichment planting; Pioneer stands; Root competition; Soil compaction; Sabah | 1998 |
| 270 |
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Jorgensen, Erik | Wormwholes: a commentary on K. F. Schaffner's "Genes, behavior, and developmental emergentism | Although Caenorhabditis elegans was chosen and modified to be an organism that would facilitate a reductionist program for neurogenetics, recent research has provided evidence for properties that are emergent from the neurons. While neurogenetic advances have been made using C elegans which may be u... | Organism; Neurons; Genotype | 1998 |
| 271 |
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Goller, Franz | Vibratory behavior of the sound generating structures of the bird syrinx | Recent endoscopic studies of the bird syrinx during phonation suggest that sound is generated by vibrating membrane folds or labia (Goller and Larsen, J. exp. Biol., 200, 2165-2176, 1997; Goller and Larsen, Proc. Natl. Acad. Sci., 4,14787-14791, 1997) and not by a whistle mechanism (Nottebohm, J. ... | Vocalization; Vibration detector; Whistle mechanism | 1998 |
| 272 |
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Goller, Franz | Ontogeny of song lateralization in juvenile northern cardinals | In adult northern cardinals (Cardinatte cardinalis), the left and right sides of the syrinx cover different vocal registers such (hat fundamental frequencies below about 3.5 or 4 kHz are produced only by the left syrinx and higher frequencies are produced primarily by the light syrinx. | Motor control; FM sweep; Subsong | 1998 |
| 273 |
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Capecchi, Mario R. | Hoxc13 mutant mice lack external hair | Hox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibri... | Filiform papillae; Homozygotes; Paralogous | 1998-01-01 |
| 274 |
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Capecchi, Mario R. | Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. | The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches. Hoxa3 mutant homozygotes have defects in the development of all three organs. Roles for the Hoxa3 para... | Animals, Newborn; Calcitonin; Ectoderm; Gene Dosage; Genotype; Mice, Mutant Strains; Phenotype | 1998-03-01 |
| 275 |
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Capecchi, Mario R. | Detection of targeted GFP-Hox gene fuogenesissions during mouse embry. | The ability to use a vital cell marker to study mouse embryogenesis will open new avenues of experimental research. Recently, the use of transgenic mice, containing multiple copies of the jellyfish gene encoding the green fluorescent protein (GFP), has begun to realize this potential. Here, we show ... | Chimera; Crosses, Genetic; Gestational Age; Green Fluorescent Proteins; Mice, Inbred C57BL; Phenotype | 1998-10-27 |
