Filters: Department: "Biomedical Informatics" Collection: "ir_uspace" Type: "Text" School Or College: "School of Medicine"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 226 |
 |
Mitchell, Joyce A. | A decision-support system for the analysis of clinical practice patterns | Several studies documented substantial variation in medical practice patterns, but physicians often do not have adequate information on the cumulative clinical and financial effects of their decisions. The purpose of developing an expert system for the analysis of clinical practice patterns was to a... | 1994-01-01 | |
| 227 |
 |
Warner, Homer R. | A Computer-Based Diagnostic Model for Individual Case Review | Biomedical Informatics | 1995 | |
| 228 |
 |
Warner, Homer R. | Computerized Practice Guidelines for Heart Failure Management: The HeartMan System | Biomedical Informatics | 1995 | |
| 229 |
 |
Warner, Homer R. | Enroute Toward a Computer-Based Patient Record: The ACIS Project | Biomedical Informatics | 1995 | |
| 230 |
 |
Warner, Homer R. | Assessing the Behavioral Impact of a Diagnostic Decision Support System | Biomedical Informatics | 1995 | |
| 231 |
 |
Blumenthal, Donald K. | Identification of the substrate and pseudosubstrate binding sites of phosphorylase kinase gamma-subunit. | Using site-directed mutagenesis, we proposed that an autoinhibitory domain(s) is located at the C-terminal region (301-386) of the phosphorylase kinase gamma-subunit (Huang, C.-Y.F., Yuan C.-J., Livanova, N.B., and Graves, D.J. (1993) Mol. Cell. Biochem. 127/128, 7-18). Removal of the putative inhib... | Mutagenesis; Autoinhibitory Domain; Peptides | 1995-03-31 |
| 232 |
 |
Blumenthal, Donald K. | Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase. | Limited proteolysis has been utilized to study the structural organization of rabbit skeletal muscle myosin light chain kinase. The enzyme (Mr approximately 89,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis) consists of an amino-terminal, protease-susceptible region of unidentified... | Enzymology; Skeletal Muscle; Proteolysis, Peptide Fragments | 1995-09-15 |
| 233 |
 |
Blumenthal, Donald K. | Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory. | Phosphorylase kinase is a multimeric protein kinase (alpha 4 beta 4 gamma 4 delta 4) whose enzymatic activity is conferred by its gamma-subunit. A library of 18 overlapping synthetic peptides spanning residues 277-386 of the gamma-subunit has been prepared to use in identifying important regulatory ... | Metabolism; Phosphorylase Kinase | 1995-09-22 |
| 234 |
 |
Warner, Homer R. | Quality Assessment and Patient Participation in Care by Means of a Touch-Screen Computer | Biomedical Informatics | 1996 | |
| 235 |
 |
Mitchell, Joyce A. | The Missouri planning grant for the education and training of health sciences librarians | The planning grant at the School of Library and Informational Science (SLIS) at the University of Missouri has two aims: (a) developing a model curriculum for health sciences librarianship at the master's level and (b) developing materials that can be delivered by alternative instructional methods. ... | 1996-01-01 | |
| 236 |
 |
Mitchell, Joyce A. | Beyond relevance--characteristics of key papers for clinicians: an exploratory study in an academic setting | Objective: The purpose of this study was to determine what factors beyond relevance influence a clinician's decision to choose to read one journal article over another in satisfying an information need. Design: Seventeen health care providers were interviewed and then surveyed regarding the characte... | 1996-01-01 | |
| 237 |
 |
Warner, Homer R. | Subtotal Hysterectomy in Modern Gynecology: A Decision Analysis | Biomedical Informatics | 1997 | |
| 238 |
 |
Warner, Homer R. | The HELP Hospital Information System: Update 1998 | Biomedical Informatics | 1999 | |
| 239 |
 |
Mitchell, Joyce A. | From phenotype to genotype: issues in navigating the available information resources | Objectives-As part of an investigation of connecting health professionals and the lay public to both disease and genomic information, we assessed the availability and nature of the data from the Human Genome Project relating to human genetic diseases. Methods-We focused on a set of single gene disea... | 2003-01-01 | |
| 240 |
 |
Gardner, Reed M. | Computerized Clinical Decision-Support in Respiratory Care | Biomedical Informatics | 2004 | |
| 241 |
 |
Mitchell, Joyce A. | Design and evaluation of a personal digital assistant-based alerting service for clinicians | Purpose: This study describes the system architecture and user acceptance of a suite of programs that deliver information about newly updated library resources to clinicians' personal digital assistants (PDAs). Description: Participants received headlines delivered to their PDAs alerting them to new... | 2004-01-01 | |
| 242 |
 |
Mitchell, Joyce A. | Evidence-based retrieval in evidence-based medicine | Objective: Clinical decisions based on a meta-analysis that is based on an ineffective retrieval strategy may have serious negative consequences for patients. The study objective was to investigate the extent to which meta-analyses report proof of their retrieval strategies' effectiveness. Methods: ... | 2004-01-01 | |
| 243 |
 |
Gardner, Reed M. | The International Partnership for Health Informatics Education: Lessons Learned from Six Years of Experience | Biomedical Informatics | 2005 | |
| 244 |
 |
Blumenthal, Donald K.; Trewhella, Jill | Conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. | Different isoforms of the full-length protein kinase A (PKA) regulatory subunit homodimer (R2) and the catalytic (C) subunit-bound holoenzyme (R2C2) have very different global structures despite similar molecular weights and domain organization within their primary sequences. To date, it has been th... | Protein Isoforms; Global Structures; cAMP | 2005-10-21 |
| 245 |
 |
Gardner, Reed M. | Impact of CPOE on Mortality Rates - Contradictory Findings, Important Messages | Biomedical Informatics | 2006 | |
| 246 |
 |
Mitchell, Joyce A. | Fuzzy measures on the Gene Ontology for gene product similarity | One of the most important objects in bioinformatics is a gene product (protein or RNA). For many gene products, functional information is summarized in a set of Gene Ontology (GO) annotations. For these genes, it is reasonable to include similarity measures based on the terms found in the GO or othe... | 2006-01-01 | |
| 247 |
 |
Mitchell, Joyce A. | Challenges and strategies of the Genetics Home Reference | Objective: This paper focuses on the first two years of operation of Genetics Home Reference (GHR), a Web-based resource <http://www.ghr.nlm.nih.gov> for the general public that helps to explain the health implications of findings from the Human Genome Project. Methods and Findings: Key challenges o... | 2006-01-01 | |
| 248 |
 |
Mitchell, Joyce A. | Personalized medicine | With the completion of the Human Genome Project in 2003, the world's attention has focused on converting this vast storehouse of information into innovative health care solutions. The ultimate promise, assuming we know everyone's genotype, is to ensure that every person has optimum health throughout... | 2007-01-01 | |
| 249 |
 |
Mitchell, Joyce A. | Bioinformatics linkage of heterogeneous clinical and genomic information in support of personalized medicine | Objectives: Biomedical Informatics as a whole faces a difficult epistemological task, since there is no foundation to explain the complexities of modeling clinical medicine and the many relationships between genotype, phenotype, and environment. This paper discusses current efforts to investigate su... | 2007-01-01 | |
| 250 |
 |
Huser, Vojtech | Running decision support logic retrospectively to determine guideline adherence: a case study with diabetes | We describe the application of our previously developed analytical infrastructure called RetroGuide to conduct studies on retrospective data using a clinician friendly flowchart paradigm. Introduction Requiring additional clinician?s input in a new decision support system (DSS) is often a major imp... | retroguide; time series analysis; retrospective observational study; diabetes; hypertension; clinical guidelines; knowledge representation; RetroGuide | 2007-05-14 |