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1 Probabilistic white matter fiber tracking using, particle filtering and von mises-fisher samplingGerig, GuidoStandard particle filtering technique have previously been applied to the problem of fiber tracking by Brun et al. (2002) and Bjornemo et al. (2002). However, these previous attempts have not utilised the full power of the technique, and as a result the fiber paths were tracked in a goal directed wa...2009-01-01
2 Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2Gerig, GuidoBackground-Enlargement of the lateral ventricles is thought to originate from abnormal prenatal brain development and is associated with neurodevelopmental disorders. Fetal isolated mild ventriculomegaly (MVM) is associated with enlargement of lateral ventricle volumes in the neonatal period and dev...2012-01-01
3 Particle based shape regression of open surfaces with applications to developmental neuroimagingGerig, GuidoShape regression promises to be an important tool to study the relationship between anatomy and underlying clinical or biological parameters, such as age. In this paper we propose a new method to building shape models that incorporates regression analysis in the process of optimizing correspondences...2009-01-01
4 Group analysis of DTI fiber tract statistics with application to neurodevelopmentGerig, GuidoDiffusion tensor imaging (DTI) provides a unique source of information about the underlying tissue structure of brain white matter in vivo including both the geometry of major fiber bundles as well as quantitative information about tissue properties represented by derived tensor measures. This paper...2009-01-01
5 Spatiotemporal atlas estimation for developmental delay detection in longitudinal datasetsGerig, GuidoWe propose a new methodology to analyze the anatomical variability of a set of longitudinal data (population scanned at several ages). This method accounts not only for the usual 3D anatomical variability (geometry of structures), but also for possible changes in the dynamics of evolution of the str...2009-01-01
6 Neuroimaging of structural pathology and connectomics in traumatic brain injury: toward personalized outcome predictionGerig, GuidoRecent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functionalmagnetic resonance imaging (MRI and fMRI, respectively) as well as diffusion tensor imaging (DTI) has excellent potential to identify novel biomark...2012-01-01
7 Simulation of brain tumors in MR images for evaluation of segmentation efficacy.Gerig, GuidoObtaining validation data and comparison metrics for segmentation of magnetic resonance images (MRI) are difficult tasks due to the lack of reliable ground truth. This problem is even more evident for images presenting pathology, which can both alter tissue appearance through infiltration and cause ...2009-01-01
8 Affluent hunters? Some comments in light of the Alyawara caseHawkes, KristenOur recent analysis (O'Connell and Hawkes in press) of plant food collecting among the Alyawara, a central Australian hunting group, shows that the cost of subsistence is sometimes quite high, far higher than the current conven. tional wisdom regarding hunters would suggest. We infer from available ...1981-01-01
9 Kin selection and cultureHawkes, KristenThis paper argues that while the discriminations organizing human action are cultural, and kinship in anthropology is not equivalent to genetic relatedness, the theory of kin selection developed in evolutionary biology can tell us a great deal about human social organization. Data on garden assistan...1983-01-01
10 Quantitative tract-based white matter development from birth to age 2 yearsGerig, GuidoFew large-scale studies have been done to characterize the normal human brain white matter growth in the first years of life. We investigated white matter maturation patterns in major fiber pathways in a large cohort of healthy young children from birth to age two using diffusion parameters fraction...2012-01-01
11 Brain lesion segmentation through physical model estimationGerig, GuidoSegmentations of brain lesions from Magnetic Resonance (MR) images is crucial for quantitative analysis of lesion populations in neuroimaging of neurological disorders. We propose a new method for segmenting lesions in brain MRI by inferring the underlying physical models for pathology. We use the r...2008-01-01
12 Evaluation of brain MRI alignment with the Robust Hausdorff Distance MeasuresGerig, GuidoWe present a novel automated method for assessment of image alignment, applied to non-rigid registration of brain Magnetic Resonance Imaging data (MRI) for image-guided neurosurgery. We propose a number of robust modifications to the Hausdorff distance (HD) metric, and apply it to the edges recovere...2008-01-01
13 Using a sharp metal tip to control the polarization and direction of emission from a quantum dotGerton, JordanOptical antennas can be used to manipulate the direction and polarization of radiation from an emitter. Usually, these metallic nanostructures utilize localized plasmon resonances to generate highly directional and strongly polarized emission, which is determined predominantly by the antenna geometr...2014-01-01
14 Ovarian follicle loss in humans and mice: lessons from statistical model comparisonHawkes, KristenMenopause is triggered by the number of ovarian follicles falling below a threshold number and is irreversible because oogonial stem cells disappear after birth. Since it is the result of programmed disappearance of a limited store of follicles, menopause can be predicted using mathematical models b...2010-01-01
15 Age-related decline in ovarian follicle stocks differ between chimpanzee (Pan troglodytes) and humansHawkes, KristenSimilarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (Pan troglodytes) showed follicle stock decline at the same ...2015-01-01
16 Grandmothers and the evolution of human longevity: a review of findings and future directionsHawkes, KristenWomen and female great apes both continue giving birth into their forties, but not beyond. However humans live much longer than other apes do.[1] Even in hunting and gathering societies, where the mortality rate is high, adult life spans average twice those of chimpanzees, which become decrepit duri...2013-01-01
17 Human actuarial aging increases faster when background death rates are lower: a consequence of differential heterogeneity?Hawkes, KristenMany analyses of human populations have found that age-specific mortality rates increase faster across most of adulthood when overall mortality levels decline. This contradicts the relationship often expected from Williams' classic hypothesis about the effects of natural selection on the evolution o...2011-01-01
18 Mortality and fertility rates in humans and chimpanzees: how within-species variation complicates cross-species comparisonsHawkes, KristenA grandmother hypothesis may explain why humans evolved greater longevity while continuing to end female fertility at about the same age as do the other great apes. With that grandmother hypothesis in mind, we sought to compare age-specific mortality and fertility rates between humans and chimpanzee...2009-01-01
19 Grandmother effects, heterogeneity, and the evolution of human aging: guidance from human-chimpanzee comparisonsHawkes, KristenIn the first paper to present formal theory explaining that senescence is a consequence of natural selection, W. D. Hamilton concluded that human postmenopausal longevity results from the contributions of ancestral grandmothers to the reproduction of their relatives. A grandmother hypothesis, subseq...2010-01-01
20 Brief communication: adrenal androgens and aging: female chimpanzees (Pan troglodytes) compared with womenHawkes, KristenOvarian cycling continues to similar ages in women and chimpanzees yet our nearest living cousins become decrepit during their fertile years and rarely outlive them. Given the importance of estrogen in maintaining physiological systems aside from fertility, similar ovarian aging in humans and chimpa...2013-01-01
21 Diffusion imaging quality control via entropy of principal direction distributionGerig, GuidoDiffusion MR imaging has received increasing attention in the neuroimaging community, as it yields new insights into the microstructural organization of white matter that are not available with conventional MRI techniques. While the technology has enormous potential, diffusion MRI suffers from a uni...2013-01-01
22 Quantification of measurement error in DTI: theoretical predictions and validationGerig, GuidoThe presence of Rician noise in magnetic resonance imaging (MRI) introduces systematic errors in diffusion tensor imaging (DTI) measurements. This paper evaluates gradient direction schemes and tensor estimation routines to determine how to achieve the maximum accuracy and precision of tensor derive...2007-01-01
23 Hypothesis testing with nonlinear shape modelsGerig, GuidoWe present a method for two-sample hypothesis testing for statistical shape analysis using nonlinear shape models. Our approach uses a true multivariate permutation test that is invariant to the scale of different model parameters and that explicitly accounts for the dependencies between variables. ...2005-01-01
24 Automatic and robust computation of 3D medial models incorporating object variabilityGerig, GuidoAbstract. This paper presents a novel processing scheme for the automatic and robust computation of a medial shape model which represents an object population with shape variability. The sensitivity of medial descriptions to object variations and small boundary perturbations are fundamental problems...2003-01-01
25 Object models in multiscale intrinsic coordinates via m-repsGerig, GuidoObject descriptions used for 3D segmentation by deformable models and for statistical characterization of 3D object classes benefit from having intrinsic correspondences over deformation of the objects or multiple instances in the same object class. These correspondences apply over a variety of spat...2003-01-01
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