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TitleDescriptionSubject
176 Saccadic Pathways in the Brainstem and Cerebellum & Mechanism for Saccadic Dysmetria in Wallenberg Syndrome - Normal Function of the Brainstem/Cerebellar Saccadic PathwaysThe inferior cerebellar peduncle (ICP) carries climbing fibers to the dorsal vermis, and these fibers have an inhibitory influence over the Purkinje cells. These Purkinje cells normally inhibit the ipsilateral fastigial nucleus, and the fastigial nucleus projects to the contralateral inhibitory burs...Medulla OMS; Normal Saccades; Abnormal Saccades; Figures
177 Saccadic Smooth Pursuit and Vestibulo-ocular Reflex Suppression (VORS)𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 20-yo-man who suffered a left MCA stroke years prior. Upon evaluation of his eye movements, saccades and all classes of eye movements were normal, although his smooth pursuit and VORS were choppy to the left (ip...Smooth Pursuit; Vestibulo-ocular Reflex (VOR) Supression
178 Sagging Eye Syndrome and Cerebellar Disease in Divergence Insufficiency𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 70-year-old woman who presented with diplopia at distance. Her exam demonstrated orthophoria at near with a fairly comitant 8-10 PD esotropia at distance without abduction paresis, consistent with divergence ins...Abnormal Alignment; OMS Cerebellar; Jerk Nystagmus; Gaze Evoked Nystagmus; Divergence Insufficiency
179 Sagittal Section of the Brainstem Showing Structures Related to Normal Eyelid FunctionSeen here is a sagittal view of the brainstem, with the structures relevant to normal eyelid function highlighted. The M-group, which can be found medial to the riMLF (coordinates eye and lid movements), has (weak) projections to the facial nucleus for frontalis muscle contraction, and (strong) proj...Figures; Mesencephalon OMS
180 Sagittal Section of the Midbrain Showing Structures Related to Normal Eyelid Function𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: During a vertical saccade, the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) is activated, which excites the superior rectus (SR) and inferior oblique (IO) (IIIrd nerve) subnuclei. Additionall...Figures; Mesencephalon OMS
181 Semicircular PathwaysOnce the semicircular canal fibers leave the peripheral labyrinth, they synapse in the ipsilateral vestibular nucleus, and then ascend to the ocular motor nuclei. This enables the vestibulo-ocular reflex to respond to head movements in the plane of any canal or combination of canals.Vestibulo-Ocular Reflex
182 Sequelae of Cerebellar Hemorrhage - Gaze-evoked Nystagmus, Alternating Skew Deviation and Palatal TremorThis is a 75-yo-woman presenting with a gait disorder. Two years prior, she suffered a cerebellar hemorrhage. On examination, there were typical cerebellar ocular motor signs including gaze-evoked nystagmus, choppy smooth pursuit and VOR suppression, and saccadic dysmetria. There was also an alterna...Assessing Abnormal Alignment; Jerk Nystagmus; Gaze Evoked Nystagmus; Oculopalatal Myoclonus
183 Sequential Vasculopathic 3rd Nerve Palsies with Preserved 4th Nerve Function65-yo-man with uncontrolled diabetes who developed sequential vasculopathic 3rd nerve palsies. In attempted downgaze, there's clear incyclotorsion OU suggestive of preserved 4th nerve function on both sides. There was complete recovery over months. Video shows bilateral 3rd nerve palsies with intact...Third (Oculomotor) Nerve Palsy; Third Subnuclear
184 Sitting & Walking Oscillopsia in a Patient with Bilateral Vestibular Loss & Head TremorThis is a 55-year-old man with oscillopsia for two reasons: He experienced oscillopsia at rest - so-called ‘sitting' oscillopsia - not from spontaneous nystagmus, but because of a combination of bilateral vestibular loss (BVL) and a mainly horizontal head tremor (this is sometimes referred to a...Vestibulo-Cochlear Nerve
185 Skew Deviation and the Triad of the Ocular Tilt Reaction (OTR)This is a patient who presented with vertical diplopia, who was found to have a complete ocular tilt reaction including the following features: (1) Skew deviation - right hypertropia that was about 30 prism diopters in all directions of gaze including right, left, up, down, as well as in right and ...
186 Slow Abducting Saccade in 6th Nerve Palsy40-yo-man with a right fascicular 6th nerve palsy due to stroke. There was improvement and only a minimal residual right abduction paresis OD by this visit, but still a relatively slow right abducting saccade seen in the video, especially apparent in the slow motion segment. Video shows slow abduct...Sixth (Abducens) Nerve Palsy; Abnormal Saccades
187 Slow Horizontal, Vertical and Oblique Saccades in Spinocerebellar Ataxia Type IThis is a patient presenting with horizontal diplopia who was found to have divergence insufficiency, an esotropia greater at distance than near in the absence of abduction paresis. She also had very slow saccades, more so vertically than horizontally. This is particularly noticeable when asking h...
188 Slow Horizontal, Vertical, Oblique Saccades and Gaze-evoked Nystagmus in Anti-AGNA-1 EncephalitisThis is a patient who presented subacutely with imbalance and dizziness. On examination, she had evidence of gaze evoked nystagmus, right internuclear ophthalmoplegia, as well as slow saccades horizontally and vertically. She was diagnosed with a rare antibody-mediated disorder, anti-AGNA-1 (antig...
189 Spinocerebellar Ataxia Type 3 with Gaze-Evoked Nystagmus and Bilateral Vestibular Loss𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 50-year-old woman with an established diagnosis of spinocerebellar ataxia type 3 (SCA 3) with severe imbalance and head movement-induced oscillopsia. On examination, she had 1) bilateral vestibular loss (BVL) de...Jerk Nystagmus; Gaze-Evoked Nystagmus; Abnormal VOR-HIT; Eighth Nerve; Abnormal Pursuit
190 Spontaneous Torsional Nystagmus and Ocular Tilt Reaction𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 70-year-old man who experienced "a delay in focusing" with "some twisting movement" that began about 18 months prior to this video with mild progression over days or weeks. For the same period of time, he experi...Jerk Nystagmus; Rotary Nystagmus; Abnormal Alignment
191 Square Wave Jerks and Macrosaccadic Oscillations in a Patient with a Cerebellar TumorThis is a 40-year-old man who developed severe headaches, confusion, and gait imbalance which led to neuroimaging which demonstrated a midline cerebellar mass with compression of the fourth ventricle and obstructive hydrocephalus. He underwent a suboccipital craniectomy for resection of the mass, an...Abnormal Saccades; Square Wave Jerks
192 Subtle Torsional Pendular Nystagmus in Oculopalatal Tremor (OPT)𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 50-year-old woman who presented with imbalance, and MRI demonstrated a right cerebellar cavernous malformation. She underwent surgery to resect the malformation, and post-operatively experienced right hemiparesi...Pendular Nystagmus; Oculopalatal Tremor
193 Subtle Torsional Pendular Nystagmus in Oculopalatal Tremor (OPT) (Figure 1)This is a 50-year-old woman who presented with imbalance, and MRI demonstrated a right cerebellar cavernous malformation. She underwent surgery to resect the malformation, and post-operatively experienced right hemiparesis and ataxia. Six months after the surgery, balance worsened and vision became ...Pendular Nystagmus; Oculopalatal Tremor
194 Superior Oblique Myokymia (SOM)𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a patient with transient monocular oscillopsia OD and vertical diplopia noted to have many episodes of SOM in the office. There was not only myokymia OD, but also a 4 prism diopter left hypertropia during episodes...Superior Oblique Myokymia; Transient Monocular Oscillopsia; Vertical Diplopia
195 Superior Oblique Myokymia - Three Patients with Recorded Attacks Using VOG and Frenzel Goggles𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: Patients with superior oblique myokymia (SOM) commonly present with complaints of monocular oscillopsia and/or vertical diplopia, which are related to the primary and secondary actions of the SO (incycloduction and depres...Superior Oblique Myokymia; Fourth Troclear Nerve; Abnormal Alignment
196 Supine Roll TestSupine roll test: used to test for horizontal canal (HC) BPPV. While horizontal nystagmus due to HC-BPPV is often seen with DH, the roll test will usually maximize nystagmus and vertigo with the HC variant. The patient can be guided through a self-administered supine roll test while lying on the flo...Supine Roll Test
197 Test Your Knowledge - Ocular Tilt Reaction and Subjective Visual VerticalLesions of which of the following neuro-anatomic structures could result in the clinical findings shown? A. Right medulla B. Right interstitial nucleus of Cajal C. Right medial longitudinal fasciculus D. Left trochlear nerve E. Right caudal midbrain A. Correct. This patient presents with elements...Skew
198 Test Your Knowledge - Parinaud's Syndrome in NeurosarcoidosisWatch the first segment of the video up to "Stop! What would you expect with vertical gaze?" and select the best response below. The patient also has mild right-beating nystagmus which can be ignored for the purposes of this question. A. The patient has pupillary findings consistent with bilateral 3...Normal Convergence; Vertical Gaze Palsy; Upgaze Palsy; Dorsal Midbrain; Mesencephalon; Convergence Retraction
199 Third and Sixth Nerve Palsies Due to Cavernous Sinus MeningiomaThis is a 60-year-old woman with a large meningioma that was compressing the right cavernous sinus. Examination demonstrated a pupil-involving right 3rd nerve palsy with near complete external ophthalmoplegia (involving levator palpebrae, medial rectus, superior rectus, inferior rectus). There was a...Third Nerve Palsy; Fourth Nerve Palsy; Sixth Nerve Palsy
200 Third Nerve Palsy Due to Tolosa Hunt SyndromeThis is a 20-year-old woman presenting with severe left eye pain and diplopia for several days. Examination was consistent with a pupil sparing left 3rd nerve palsy with complete external ophthalmoplegia (involving levator palpebrae, medial rectus, superior rectus, inferior rectus). Abduction OS was...Third Nerve Palsy; Tolosa Hunt Syndrome
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