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Capecchi, Mario R. | Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma | Angiotensin-converting enzyne (ACE) is a pepitdase responsible for the cleavage of angiotensin I and Several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10... | Macrophage enzyme; Melanoma resistance; Enhanced macrophage angiotensin-converting enzyme | 2007 |