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CreatorTitleDescriptionSubjectDate
576 Beckerle, Mary C.Molecular dissection of a LIM domainLIM domains are novel sequence elements that are found in more than 60 gene products, many of which function as key regulators of developmental pathways. The LIM domain, characterized by the cysteine-rich consensus CX2CX16_23HX2CX2CX2CX16_21CX2-3(C/H/ D), is a specific metal-binding structure tha...LIM domains; Metal-binding; Zyxin; Cysteine-rich proteins1997
577 Gerig, GuidoMulti-object analysis of volume, pose, and shape using statistical discriminationOne goal of statistical shape analysis is the discrimination between two populations of objects. Whereas traditional shape analysis was mostly concerned with single objects, analysis of multi-object complexes presents new challenges related to alignment and pose. In this paper, we present a methodol...2010-01-01
578 Kowaleski-Jones, Lori; Fan, Jessie Xiaojing; Brown, Barbara B.; Smith, Ken R.; Zick, Cathleen D.Patterns of household food expenditures: a cluster analysisIn this study we use the Diary Survey component of the 2001 and 2002 Consumer Expenditure Survey to investigate patterns of household food expenditures. We identify eight constellations of food expenditures that are more and less likely to be associated with healthy eating habits. These clusters in...Diet; Fast food; Nutrition; Eating habits2007
579 Diamond, LisaPsychobiological perspectives on attachment: implications for health over the lifespanOne of the most robust findings to emerge from health psychology over the past 30 years is that individuals in enduring, committed romantic relationships have longer, healthier, and happier lives than unmarried individuals (Kitigawa & Hauser, 1973; Ryff, Singer, Wing, & Love, 2001; Stack & Eshleman,...Health Psychology; Psychobiology; Relationships; Well-being2004
580 Capecchi, Mario R.Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune systemMammalian TBP consists of a 180 amino acid core that is common to all eukaryotes, fused to a vertebrate-specific N-terminal domain. We generated mice having a modified tbp allele, tbp(DeltaN), that produces a version of TBP lacking 111 of the 135 vertebrate-specific amino acids. Most tbp(DeltaN/Delt...Alleles; Animals, Genetically Modified; Binding Sites; Embryonic and Fetal Development; Evolution, Molecular; Female; Fetus; Immune Tolerance; Male; Mice; Mutation; ATA-Box Binding Protein2002-07-12
581 Capecchi, Mario R.Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1Mouse selenoprotein P (Sepp1) consists of an N-terminal domain (residues 1-239) that contains 1 selenocysteine (U) as residue 40 in a proposed redox-active motif (-UYLC-) and a Cterminal domain (residues 240-361) that contains 9 selenocysteines. Sepp1 transports selenium from the liver to other tiss...2014-01-01
582 Olivera, Baldomero M.T-superfamily of conotoxinsWe report the discovery and initial characterization of the T-superfamily of conotoxins. Eight different T-superfamily peptides from five Conus species were identified; they share a consensus signal sequence, and a conserved arrangement of cysteine residues (- -CC- -CC-). T-superfamily peptides...Conotoxins; T-superfamily1999
583 Coley, Phyllis D.Tritrophic interactions in tropical versus temperate communitiesThe latitudinal gradient in diversity is one of the oldest (e.g., Wallace, 1878) and most obvious trends in ecology, and a wealth of literature is devoted to understanding both the causes and consequences of this gradient (Dobzhansky, 1950; also reviewed by Rohde, 1992). Given the enormous latitudi...Tritrophic interactions; Trophic cascades; Herbivory; Tropical communities; Temperate communities2002
584 Gehl, Robert W.Building a blog cabin during a financial crisis: circuits of struggle in the digital enclosureOne of the most pressing questions facing television studies is how to understand the migration of media production and consumption onto web applications which depend on user-generated content. Scholars inspired by the political economy of communication (PEC) tradition have focused on how the accumu...2011
585 Olivera, Baldomero M.Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magusWe describe the purification and first biochemical characterization of an enzymatic activity in venom from the marine snail Conus magus. This enzyme, named conodipine-M, is a novel phospholipase A2 with a molecular mass of 13.6 ĸDa and is comprised of two polypeptide chains linked by one or more di...Conotoxins; Conodipine-M; Conus magus1994
586 Hughes, Kelly T.Flagellar-specific transcription factor, σ28, is the Type III secretion chaperone for the flagellar-specific anti-σ28 factor FlgMThe σ28 protein is a member of the bacterial σ70-family of transcription factors that directs RNA polymerase to flagellar late (class 3) promoters. The σ28 protein is regulated in response to flagellar assembly by the anti-σ28 factor FlgM. FlgM inhibits σ28-dependent transcription of genes wh...Flagellum; gene regulation; Type III secretion; FlgM2006
587 LaStayo, Paul C.Intermuscular fat: a review of the consequences and causesMuscle's structural composition is an important factor underlying muscle strength and physical function in older adults. There is an increasing amount of research to support the clear disassociation between the loss of muscle lean tissue mass and strength with aging. This disassociation implies that...2014-01-01
588 Capecchi, Mario R.Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.Biochemical transformation of thymidine-kinase-deficient (TK-) mouse L cells is enhanced 20 to 40 fold when microinjected plasmid DNA contains regions of the genomes of Rous sarcoma virus or simian virus 40 in addition to the complete herpes simplex virus tk gene, irrespective of the orientation and...Animals; Base Sequence; Genes, Viral; Plasmids; Thymidine Kinase1983-07-01
589 Beckerle, Mary C.Molecular characterization of human zyxinZyxin is a component of adhesion plaques that has been suggested to perform regulatory functions at these specialized regions of the plasma membrane. Here we describe the isolation and characterization of cDNAs encoding human and mouse zyxin.Zyxin; Proline; LIM domains1996
590 Voth, Gregory AlanMultiscale coarse-graining of the protein energy landscapeA variety of coarse-grained (CG) models exists for simulation of proteins. An outstanding problem is the construction of a CG model with physically accurate conformational energetics rivaling all-atom force fields. In the present work, atomistic simulations of peptide folding and aggregation equilib...2010-06-24
591 Fan, Jessie X., Yu, ZhouPrevalence and Risk Factors of Consumer Financial Fraud in ChinaThis study estimates the prevalence of consumer fraud in China and investigates consumer fraud risk factors using a novel two-stage conceptual framework that differentiates fraud exposure from fraud victimization after exposure. Multivariate analyses show that multiple risk factors have opposite eff...Consumer financial fraud victimization; China; migrants; financial knowledge; risk attitude
592 Firmage, Edwin B.MX:democracy, religion and the rule of law--my journeyThis is my story of the defeat of the MX missile's proposed basing mode in the Great Basin of the West. Where to begin? I'm reflecting on cancer and MX at this moment. About journeys where we would not go but do. Beginnings are not easy, though the first verses of Genesis and John make them sound so...Missile Experimental; Great Basin; Cold War2004
593 Beckerle, Mary C.Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and AktThis study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces r...Zyxin; Akt; Cyclic guanosine monophosphate2005
594 Beckerle, Mary C.; Clark, Kathleen A.Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegansWe describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula...LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development1999
595 Fuhrmann, Sabine; Zhang, Jianmin; Vetter, Monica L.Investigation of Frizzled-5 during embryonic neural development in mouseCellular and tissue--tissue interactions regulate development of the central nervous system (CNS) and a paramount question is what is the nature of the signals involved in these interactions. The vertebrate eye represents an excellent and challenging CNS model because it contains multiple cell and ...Mouse; Eye; Optic cup; Morphogenesis; Retina; Lens; Wnt; Frizzled; Pituitary2008
596 Adler, Frederick R.Long-term models of oxidative stress and mitochondrial damage in insulin resistance progressionInsulin resistance, characterized by a reduced cellular response to insulin, is a major factor in type 2 diabetes pathogenesis, with a complex etiology consisting of a combination of environmental and genetic factors. Oxidative stress, which develops through an accumulation of toxic reactive oxygen ...2014-01-01
597 Rogers, Alan R.; Jorde, Lynn B.Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic dataTo test hypotheses about the origin of modern humans, we analyzed mtDNA sequences, 30 nuclear restriction-site polymorphisms (RSPs), and 30 tetranucleotide short tandem repeat (STR) polymorphisms in 243 Africans, Asians, and Europeans. An evolutionary tree based on mtDNA displays deep African branch...Base Sequence; Variation (Genetics); Base Sequence1995
598 Sung, Younghoon; Kondo, Douglas Gavin; Jeong, Eun-Kee; Renshaw, Perry FranklinReview: magnetic resonance spectroscopy studies of pediatric major depressive disorderIntroduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health?s PubMed database was conducted to identify indexed peer-revie...2011
599 Olivera, Baldomero M.Targeted mutagenesis by homologous recombination in D. melanogasterWe used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, including the homolog of the p53 tumor suppressor. Transgenic expression of the FLP site-specific recombinase and the I-SceI endonuclease generates extrachromosomal linear DNA molecules in vivo. Thes...2002
600 Bastiani, Michael; Bandyopadhyay, Pradip K.; Olivera, Baldomero M.; Golic, Kent G.Targeted mutagenesis by homologous recombination in D. melanogasterWe used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, including the homolog of the p53 tumor suppressor. Transgenic expression of the FLP site-specific recombinase and the I-SceI endonuclease generates extrachromosomal linear DNA molecules in vivo.Mutations; Drosophila; Gene targeting2002
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