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Creator | Title | Description | Subject | Date |
501 |
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Bernstein, Paul S. | Retinal tubulin binds macular carotenoids | PURPOSE: To investigate the biochemical mechanisms responsible for the specific uptake, concentration, and stabilization of the carotenoids lutein and zeaxanthin in the macula. METHODS: Soluble extracts of bovine retina mixed with radioactive carotenoids were purified by hydrophobic interaction, ion... | Chromatography, Gel; Electrophoresis; Xanthophylls | 1997 |
502 |
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Beckerle, Mary C. | Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets | Activation of blood platelets triggers a series of responses leading to the formation and retraction of blood clots. Among these responses is the establishment of integrin-mediated transmembrane connections between extracellular matrix components and the actin cytoskeleton of the platelet. | Actin; GPIIb-IIIa | 1993 |
503 |
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Harpending, Henry C.; Jorde, Lynn B. | Culture creates genetic structure in the Caucasus: autosomal, mitochondrial, and Y-chromosomal variation in Daghestan | Near the junction of three major continents, the Caucasus region has been an important thoroughfare for human migration. While the Caucasus Mountains have diverted human traffic to the few lowland regions that provide a gateway from north to south between the Caspian and Black Seas, highland populat... | Caucasus; Haplogroups; Autosomal variation; Mitochondrial variation; Y-chromosomal variation; Endogamy; Avar; Dargin; Kubachi; Culture | 2008 |
504 |
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Florsheim, Paul W.; Ngu, Le | Differential outcomes among adolescent fathers: understanding fatherhood as a transformative process | In response to the rising numbers of mother headed households, there is a great debate about whether to encourage young unwed parents to marry. Policies designed to pursue and/or punish fathers who do not meet their legal and financial responsibilities and to promote marriage, carte blanche, are ref... | Parenting; Gender; Matrimony | 2003-10-18 |
505 |
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Kriesel, John D. | Helicase-primase inhibitor pritelivir for HSV-2 infection | Background Pritelivir, an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. We tested the efficacy and safety of pritelivir in otherwise healthy persons with genital HSV-2 infection. Methods We randomly... | | 2014-01-01 |
506 |
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Baehr, Wolfgang | Human interstitial retinoid-binding protein. Gene structure and primary structure | Interstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ... | Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA | 1989-05-15 |
507 |
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Couldwell, William T. | Irving S. Cooper (1922-1985): a pioneer in functional neurosurgery | Irving S. Cooper (1922-1985), the son of a salesman, worked his way through high school, college, and medical school to become one of the pioneers in functional neurosurgery. He developed several novel techniques for the surgical management of Parkinson's disease and other crippling movement disord... | Functional neurosurgery; Cryosurgery; Dystonia; Movement disorder; Parkinson's disease; Thalamotomy; Tremor; Neurosurgical history | 1998 |
508 |
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Gesteland, Raymond F.; Atkins, John F. | Origin and destiny of adenovirus proteins | Lytic infection of human cells by adenovirus proceeds by a temporal expression of genes. Classically two phases have been defined: an early phase, which includes events occurring before the onset of DNA synthesis (8 hours), and a late phase, including events whose existence depends on the onset of... | Protein Biosynthesis; DNA, Viral; Adenoviridae; RNA, Viral; Time Factors | 1975 |
509 |
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Frederick, Jeanne M. | The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking | Expressed ubiquitously, PrBP/d functions as chaperone/co-factor in the transport of a subset of prenylated proteins. PrBP/d features an immunoglobulin-like b-sandwich fold for lipid binding, and interacts with diverse partners. PrBP/d binds both C-terminal C15 and C20 prenyl side chains of phototran... | | 2012-01-01 |
510 |
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Simpson, Jamesina J. | Substrate integrated waveguides optimized for ultrahigh-speed digital interconnects | This paper reports an experimental and computational study of substrate integrated waveguides (SIWs) optimized for use as ultrahigh-speed bandpass waveguiding digital interconnects. The novelty of this study resides in our successful design, fabrication, and testing of low-loss SIWs that achieve 100... | | 2006-01-01 |
511 |
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Varner, Michael W. | Trial of labor or repeat cesarean delivery in women with morbid obesity and previous cesarean delivery. | OBJECTIVE: Assess effects of body mass index (BMI) on trial of labor after previous cesarean delivery and determine whether morbidly obese women have greater maternal and perinatal morbidity with trial of labor compared with elective repeat cesarean delivery. METHODS: Secondary analysis from a prosp... | Pregnancy Outcome; Obesity; Repeat Cesarean Section; Body Mass Index | 2006-07 |
512 |
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Morse, Janice M. | The illness experience: dimensions of suffering | | | 1991 |
513 |
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Olivera, Baldomero M. | P-superfamily conopeptides | The present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides. | | 2006 |
514 |
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Warner, Homer R. | A Non-Stready-State Kinetic Evaluation of the Mechanism of Cortisone-Induced Granulocytosis | Biomedical Informatics | | 1968 |
515 |
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Battin, Margaret P. | Continuous sedation until death: moral justifications of physicians and nurses─a content analysis of opinion pieces | Continuous Sedation until Death (CSD), the act of reducing or removing the consciousness of an incurably ill patient until death, often provokes medical-ethical discussions in the opinion sections of medical and nursing journals. A content analysis of opinion pieces in medical and nursing literature... | | 2012-01-01 |
516 |
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Harpending, Henry C.; Rogers, Alan R. | Detecting positive selection from genome scans of linkage disequilibrium | Though a variety of linkage disequilibrium tests have recently been introduced to measure the signal of recent positive selection, the statistical properties of the various methods have not been directly compared. While most applications of these tests have suggested that positive selection has pl... | Genome scans; Linkage disequilibrium; Gene trees | 2010 |
517 |
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Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. Michael | Differential targeting of nicotinic acetylcholine receptors by novel αA-conotoxins | We describe the isolation and characterization of two peptide toxins from Conus ermineus venom targeted to nicotinic acetylcholine receptors (nAChRs). The peptide structures have been confirmed by mass spectrometry and chemical synthesis. In contrast to the 12-18 residue, 4 Cys-containing α-co... | Conotoxins; aA-conotoxins; Conus ermineus; Peptide toxins | 1997 |
518 |
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Capecchi, Mario R. | Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. | We describe the generation of mammalian cell lines carrying amber suppressor genes. Nonsense mutants in the herpes simplex virus thymidine kinase (HSV tk) gene, the Escherichia coli xanthine-guanine phosphoribosyl transferase (Eco-gpt) gene and the aminoglycoside 3' phosphotransferase gene of the Tn... | Cercopithecus aethiops; Escherichia coli; Xenopus | 1982-11-30 |
519 |
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Capecchi, Mario R. | Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein. | The 180-amino acid core of the TATA-binding protein (TBPcore) is conserved from Archae bacteria to man. Vertebrate TBPs contain, in addition, a large and highly conserved N-terminal region that is not found in other phyla. We have generated a line of mice in which the tbp allele is replaced with a v... | Mice, Knockout; Cells, Cultured; Fibroblasts; Embryo | 2003-02-21 |
520 |
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Capecchi, Mario R. | Hoxa11 regulates stromal cell death and proliferation during neonatal uterine development | Increasing evidence indicates that the Hoxa11 gene plays a critical role in the proper development of the uterus. In this report, we describe potential altered cellular processes in the developing uterus of Hoxa11 mutants. Histologic analysis demonstrates normal uterine morphology in Hoxa11 mutants ... | | 2004 |
521 |
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Poulter, Charles Dale | Lethal mutations in the isoprenoid pathway of salmonella enterica | Essential isoprenoid compounds are synthesized using the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway in many gram-negative bacteria, some gram-positive bacteria, some apicomplexan parasites, and plant chloroplasts. The alternative mevalonate pathway is found in archaea and eukaryotes, includin... | Isoprenoids; Mutation; Bacteria; Antimicrobials | 2006 |
522 |
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Couldwell, William T. | Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngioma | Object. The authors report on a cohort of patients with craniopharyngioma treated principally through transnasal (TN) resection and followed up for a minimum of 5 years. More specifically, they evaluate the role of the TN approach in the management of craniopharyngioma. Methods. Between 1984 and 19... | | 2005-04 |
523 |
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Couldwell, William T. | Management of meningiomas involving the transverse or sigmoid sinus | Meningiomas that invade the transverse or sigmoid sinuses are uncommon tumors that are challenging to treat surgically. Although the risk of recurrence is associated with the extent of resection, complete removal of meningiomas in these locations must be balanced with avoidance of venous outflow obs... | | 2013-01-01 |
524 |
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Kerber, Richard A. | Mitochondrial genomic analysis of late onset alzheimers disease reveals protective haplogroups H6A1A/H6A1B: the Cache County study on memory in aging | Background: Alzheimer's disease (AD) is the most common cause of dementia and AD risk clusters within families. Part of the familial aggregation of AD is accounted for by excess maternal vs. paternal inheritance, a pattern consistent with mitochondrial inheritance. The role of specific mitochondrial... | | 2012-01-01 |
525 |
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Clayton, Dale H. | Molecular phylogeny of the dove genera Streptopelia and Columba | Evolutionary history of the dove genus Streptopelia has not been examined with rigorous phylogenetic methods. We present a study of phylogenetic relationships of Streptopelia based on over 3,600 base pairs of nuclear and mitochondrial gene sequences. | Doves; Streptopelia; Columba | 2001 |