Filters: Collection: "ir_uspace"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 476 |
 |
Poulter, Charles Dale | Isolation of Schizosaccharomyces pombe isopentenyl diphosphate isomerase cDNA clones by complementation and synthesis of the enzyme in Escherichia coli | Isopentenyl diphosphate (IPP) isomerase catalyzes an essential activation step in the isoprene biosynthetic pathway. The Saccharomyces cerevisiae gene for IPP isomerase, IDI1, was recently isolated and characterized (Anderson, M. S., Muehlbacher, M., Street, I. P., Proffitt, J., and Poulter, C. D. (... | Carbon-Carbon; Biosynthesis; Genetics | 1995-05-12 |
| 477 |
 |
Olivera, Baldomero M. | On the mechanism of the polynucleotide joining reaction | Polynucleotide-joining enzymes (ligases) have been identified in uninfected and phage-infected Escherichia coli (Gellert, 1967; Olivera and Lehman, 1967a; Zimmerman et al., 1967; Gefter et al., 1967; Weiss and Richardson, 1967a; Cozzarelli et al., 1967). Both types of enzyme catalyze the synthesis o... | Enzyme-AMP; Enzyme-Adenylate; DNA-Adenylate; Poly dt-Adenylate; Pyrophosphate bond | 1968 |
| 478 |
 |
O'Rourke, Dennis H. | Patterns of genetic variation in native America | Allele frequencies from seven polymorphic red cell antigen loci (ABO, Rh, MN, S, P, Duffy, and Diego) were examined in 144 Native American populations. Mean genetic distances (Nei's D) and the fixation index FST are approximately equal for the North and South American samples but are reduced in the... | Gene frequencies; Amerinds; Genetic Distance | 1992 |
| 479 |
 |
Francis, Leslie | Poverty, age discrimination, and health care | In Euripides' play Alcestis, Alcestis' middle-aged husband, Admetus, is told by the gods that it is his turn to die next. Admetus bargains a reprieve, promising in exchange to find another soul to take his place. His friends all turn him down. So do his father and mother. Admetus rebukes his father... | Alcesti, Section, Objective | 1985 |
| 480 |
 |
Gesteland, Raymond F.; Ivanov, Ivaylo P.; Atkins, John F. | Programmed frameshifting in the synthesis of mammalian antizyme is +1 in mammals, predominantly +1 in fission yeast but "2 in budding yeast | The coding sequence for mammalian ornithine decarboxylase antizyme is in two different partially overlapping reading frames with no independent ribosome entry to the second ORF. Immediately before the stop codon of the first ORF, a proportion of ribosomes undergo a quadruplet translocation event t... | Antizyme; Frameshifting; Ornithine decarboxylase antizyme; Recoding; S. pombe | 1998 |
| 481 |
 |
Schmidt, Meic H. | Spinal meningiomas: surgical management and outcome | Advances in imaging and surgical technique have improved the treatment of spinal meningiomas; these include magnetic resonance imaging, intraoperative ultrasonography, neuromonitoring, the operative microscope, and ultrasonic cavitation aspirators. This study is a retrospective review of all patient... | Spinal meningioma; Spinal tumor; Intradural; Extramedullary | 2003 |
| 482 |
 |
Capecchi, Mario R. | Xanthine oxidoreductase is central to the evolution and function of the innate immune system. | The housekeeping enzyme xanthine oxidoreductase (XOR) has been studied intensively over the past 100 years, yet the complexity of its in vivo function is still poorly understood. A large body of literature focuses on the different catalyltic forms of XOR and their importance in the synthesis of reac... | Animals; Gene Expression Regulation, Enzymologic; Humans; Immune System; Models, Biological | 2003-09-01 |
| 483 |
 |
Francis, Leslie | Ensuring the privacy and confidentiality of electronic health records | In 2004, President Bush announced his plan to ensure that most Americans would have electronic health records within ten years. Although substantial progress has been made toward achieving that goal, this progress has primarily reflected institutional interests and priorities by focusing on system ... | 2007 | |
| 484 |
 |
Mansour, Suzanne L. | Fgf10 is required for specification of non-sensory regions of the cochlear epithelium | The vertebrate inner ear is a morphologically complex sensory organ comprised of two compartments, the dorsal vestibular apparatus and the ventral cochlear duct, required for motion and sound detection, respectively. Fgf10, in addition to Fgf3, is necessary for the earliest stage of otic placode ind... | 2014-01-01 | |
| 485 |
 |
Francis, Leslie | Roles of the family in making health care decisions for incompetent patients | This article is about the roles of the family in making health care decisions for incompetent patients. It argues that complex moral reasons call for the participation of families in decision making for incompetents. However, these moral reasons do not support a single model of the family's role for... | Family; Health Care Decisions; Patients; Family Rights | 2006-06-16 |
| 486 |
 |
Beckerle, Mary C.; Hoffman, Laura M. | Supervillin modulation of focal adhesions involving TRIP6/ZRP-1 | Cell-substrate contacts, called focal adhesions (FAs), are dynamic in rapidly moving cells. We show that supervillin (SV)-a peripheral membrane protein that binds myosin II and F-actin in such cells-negatively regulates stress fibers, FAs, and cell-substrate adhesion. The major FA regulatory sequenc... | Supervillin; Focal adhesions; Zyxin; LIM domains; TRIP6 | 2006 |
| 487 |
 |
Wen, Ming | Air pollution shortens life expectancy and health expectancy for older adults: the case of China | Background: Outdoor air pollution is one of the most worrying environmental threats China faces today. Comprehensive and quantitative analysis of the health consequences of air pollution in China is lacking. This study reports age-sex-specific life expectancy (LE) and health expectancies (HEs) corre... | 2012-01-01 | |
| 488 |
 |
Baehr, Wolfgang | Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter | We have previously shown that postnatal expression of the viral oncoprotein SV40 T antigen in rod photoreceptors (transgene MOT1), at a time when retinal cells have withdrawn from the mitotic cycle, leads to photoreceptor cell death (Al-Ubaidi et al., 1992. Proc. Natl. Acad. Sci. USA. 89:1194-1198).... | Simian virus 40; Retinol-Binding Proteins; Promoter Regions (Genetics) | 1992 |
| 489 |
 |
Jameson, Kenneth P. | Data and social science rhetoric: policy and instruction | I believe that social science and empirical investigation can make important contributions to our understanding and to resolution of policy issues, but only if we are clear on the nature of social science and the role of quantification. In particular we must admit the limits of our truth claims, th... | Social sciences; Quantification; Empirical investigation | 1996 |
| 490 |
 |
Myers, Chris J. | Design of a genetic muller C-element | Synthetic biology uses engineering principles to design circuits out of genetic materials that are inserted into bacteria to perform various tasks. While synthetic combinational Boolean logic gates have been constructed, there are many open issues in the design of sequential logic gates. One such g... | 2007 | |
| 491 |
 |
Bernstein, Paul S. | Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration | 2001 | ||
| 492 |
 |
Simpson, Jamesina J. | FDTD modeling of a novel ELF radar for major oil deposits using a three-dimensional geodesic grid of the earth-ionosphere waveguide | This paper reports the first application of an optimized geodesic, three-dimensional (3-D) finite-difference time-domain (FDTD) grid to model impulsive, extremely low-frequency (ELF) electromagnetic wave propagation within the entire Earth-ionosphere cavity. This new model, which complements our pre... | 2006-01-01 | |
| 493 |
 |
Shapiro, Michael D. | Genetic architecture of parallel armor plate reduction in threespine sticklebacks | How many genetic changes control the evolution of new traits in natural populations? Are the same genetic changes seen in cases of parallel evolution? Despite long-standing interest in these questions, they have been difficult to address, particularly in vertebrates. We have analyzed the genetic bas... | Genetic changes; Plate number; Genetic mapping | 2004 |
| 494 |
 |
Wittwer, Carl T. | Genotyping accuracy of high-resolution DNA melting instruments | High-resolution DNA melting is a closed-tube method for genotyping and variant scanning that depends on the thermal stability of PCR-generated products. Instruments vary in thermal precision, sample format, melting rates, acquisition, and software. Instrument genotyping accuracy has not been assesse... | 2014-01-01 | |
| 495 |
 |
McDaniel, Susan | Les femmes dans un Canada en voie de vieillissement: une approche féministe | Le vieillessement de la population est un des thèmes majeurs de discussion en cette fin de XXe siècle, tous les pays développés étant engagés dans le processus. Certains redoutent l'insuffisance des ressources requises pour le bien-être des personnes âgées; d'autres considèrent le vieilli... | 1989 | |
| 496 |
 |
Margraf, Rebecca L.; Mao, Rong; Wittwer, Carl T. | Masking techniques: masking selected sequence variation by incorporating mismatches into melting analysis probes | Hybridization probe melting analysis can be complicated by the presence of sequence variation (non-pathogenic polymorphisms or other mutations) near the targeted mutation. We investigated the use of 'masking' probes to differentiate alleles with similar probe melting temperatures. Materials and Meth... | probe hybridization; high-resolution melting analysis; masking; RET | 2005-10-21 |
| 497 |
 |
Beckerle, Mary C.; Davis, Darrell R.; Winge, Dennis R. | Mutational analysis of the metal sites in an LIM domain | Site-directed mutagenesis was carried out map the residues that form the two Zn(I1) sites within a LIM domain. The C-terminal LIM domain derived from the cysteine-rich protein was utilized for this analysis and is referred to as LIMB. | LIM domains; Metal-binding | 1994 |
| 498 |
 |
Olivera, Baldomero M.; Gray, William Robert | New family of Conus peptides targeted to the nicotinic acetylcholine receptor | In this work, a new family of Conus peptides, the αA-conotoxins, which target the nicotinic acetylcholine receptor, is defined. The first members of this family have been characterized from the eastern Pacific species, Conus purpurascens (the purple cone); three peptides that cause paralysis in fis... | Conotoxins; Conus peptides; Conus purpurascens; Purple cone snail | 1995 |
| 499 |
 |
Miller, Jan D.; Yost, Garold S.; Veranth, John M. | Novel method to detect unlabeled inorganic nanoparticles and submicron particles in tissue by sedimentation field-flow fractionation | A novel methodology to detect unlabeled inorganic nanoparticles was experimentally demonstrated using a mixture of nano-sized (70 nm) and submicron (250 nm) silicon dioxide particles added to mammalian tissue. The size and concentration of environmentally relevant inorganic particles in a tissue sa... | Sedimentation field-flow fractionation; Transmission electron microscopy; Tissue digestion | 2008 |
| 500 |
 |
Couldwell, William T. | Pituitary apoplexy in the magnetic resonance imaging era: clinical significance of sphenoid sinus mucosal thickening | Object. The authors report their experience with pituitary apoplexy and evaluate the clinical significance of sphenoid sinus mucosal thickening found on magnetic resonance (MR) imaging. Methods. The cases of 28 patients (19 males and nine females) with pituitary apoplexy were reviewed retrospectiv... | 2006-06 |