Filters: Collection: "ir_uspace"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 26 |
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O'Rourke, Dennis H. | Introduction: origins and settlement of the indigenous populations of the Aleutian Archipelago | The series of papers in this special issue of Human Biology use an interdisciplinary approach to address regional questions and to integrate disparate Aleutian data into a broad, synthetic effort. The contributors leverage decades of data on Aleut origins, biogeography, and behavior through integrat... | 2010 | |
| 27 |
 |
Couldwell, William T. | Increased invasive capacity of connexin43-overexpressing malignant glioma cells | Object. Malignant glioma cells, similar to astrocytes, express connexin43 (Cx43) universally but at widely varied levels. Data from previous studies have demonstrated that malignant glioma cells form functional gap junction channels among themselves as well as with astrocytes and that such a communi... | 2003-12 | |
| 28 |
 |
Beckerle, Mary C.; Hoffman, Laura M.; Yoshigi, Masaaki | Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling | Focal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene... | Zyxin; Actin; Mena/VASP | 2006 |
| 29 |
 |
Capecchi, Mario R. | Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death | To investigate the local effects of angiotensin II on the heart, we created a mouse model with 100-fold normal cardiac angiotensin-converting enzyme (ACE), but no ACE expression in kidney or vascular endothelium. This was achieved by placing the endogenous ACE gene under the control of the α-myo... | Atrial enlargement; Cardiac arrhythmia; ACE | 2004 |
| 30 |
 |
Olson, Randall J. | Clinical comparison of single-piece and three-piece truncated hydrophobic acrylic intraocular lenses | PURPOSE: To determine the clinical differences between three-piece (3P) and single-piece (SP) truncated hydrophobic acrylic intraocular lenses (IOL). DESIGN: Retrospective cohort clinical study. METHODS: The setting was an academic clinical practice. The patient population consisted of subjects with... | Lenses, Intraocular; Patient Satisfaction; Postoperative Complications; Prosthesis Design; Visual Acuity | 2003-10 |
| 31 |
 |
Schmidt, Meic H. | Embolization of sacral tumors | The management of sacral tumors is challenging because of difficulties in accessing the lesion, the high rate of local recurrence, extensive vascularity causing significant intraoperative blood loss, resistance to radiation therapy, and risk of malignant transformation. Although surgery is the main ... | Sacral tumor | 2003 |
| 32 |
 |
Schmidt, Meic H. | NASA light-emitting diode medical program-progress in space flight and terrestrial applications | This work is supported and managed through the NASA Marshall Space Flight Center - SBIR Program. Studies on cells exposed to microgravity and hypergravity indicate that human cells need gravity to stimulate cell growth. As the gravitational force increases or decreases, the cell function responds in... | Terrestrial applications; Cell growth; NASA; Microgravity environment | 2000 |
| 33 |
 |
Varner, Michael W.; Esplin, Michael S. | Progression of pulmonary arteriovenous malformation during pregnancy: case report and review of the literature. | Arteriovenous Malformations; Pulmonary Artery; Pregnancy Complications; Pulmonary Veins; Pulmonary Artery | 1997-04 | |
| 34 |
 |
Levine, Edward M. | Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. | The hedgehog gene family encodes secreted proteins important in many developmental patterning events in both vertebrates and invertebrates. In the Drosophila eye disk, hedgehog controls the progression of photoreceptor differentiation in the morphogenetic furrow. To investigate whether hedgehog prot... | Sonic hedgehog; Indian hedgehog; Desert hedgehog; Retina; Mitogenesis; Differentiation; Rod Photoreceptor | 1997-08-15 |
| 35 |
 |
Couldwell, William T.; Viskochil, David H.; Fults, Daniel Webster | Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications | NEUROFIBROMATOSIS 1 (NF1) IS A common autosomal dominant disease characterized by complex and multicellular neurofibroma tumors. Significant advances have been made in the research of the cellular, genetic, and molecular biology of NF1. The NF1 gene was identified by positional cloning. The function... | Loss of heterozygosity; Malignant peripheral nerve sheath tumor; Plexiform Neurofibroma; Spinal neurofibroma | 2006 |
| 36 |
 |
Ailion, David Charles; Morris, Alan H. | Quantitative assessment of pulmonary edema by nuclear magnetic resonance methods | Considerable progress has been made in the application of nuclear magnetic resonance (NMR) imaging and nonimaging techniques to the quantitative assessment of pulmonary edema. NMR measurements offer the advantages of being noninvasive, relatively rapid, and easily repeatable. In addition, NMR imagin... | Quantitative assessment | 1988 |
| 37 |
 |
Erickson, J. Alan; Ashwood, Edward R. | Evaluation of an enzyme-linked binding protein assay for hyaluronic acid and concentrations in hepatitis C infected patients | Serological hyaluronic acid (HA) has been proposed as a noninvasive alternative to liver biopsy for assessing the extent of liver fibrosis. Liver biopsy correctly identifies hepatic disease in about 65 to 75% of cases, being strongly dependent on the length of the biopsy obtained. Furthermore, hepat... | Hyaluronic Acid Concentration; Corgenix HA assay | 2005-07-21 |
| 38 |
 |
Eisenman, Patricia A. | Hormonal changes throughout the menstrual cycle and increased anterior cruciate ligament laxity in females | OBJECTIVE: To determine whether women experience significantly greater anterior cruciate ligament (ACL) laxity in conjunction with estrogen and progesterone surges during a normal 28- to 30-day menstrual cycle. DESIGN AND SETTING: Serial estrogen and progesterone levels were measured via radioimmuno... | Estrogen; Progesterone; Knee Arthrometer; Radioimmunoassay | 1999-04 |
| 39 |
 |
Beckerle, Mary C. | Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets | Activation of blood platelets triggers a series of responses leading to the formation and retraction of blood clots. Among these responses is the establishment of integrin-mediated transmembrane connections between extracellular matrix components and the actin cytoskeleton of the platelet. | Actin; GPIIb-IIIa | 1993 |
| 40 |
 |
Jorgensen, Erik | Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development | The neurotransmitter GABA has been proposed to play a role during nervous system development. We show that the Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase (GAD), the GABA biosynthetic enzyme. unc-25 is expressed specifically in GABAergic neurons. Null mutations in unc-25... | 1999 | |
| 41 |
 |
Adler, Frederick R. | Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis | Lung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood. Biomarkers of current disease state predictive of future outcomes might identify mechanisms and provide tre... | 2012-01-01 | |
| 42 |
 |
Couldwell, William T. | Surgical treatment of craniofacial fibrous dysplasia in adults | Craniofacial fibrous dysplasia is a rare disorder that may require neurosurgical expertise for definitive management; however, surgical management of FD in adult patients is uncommon. Although other therapies have been shown to slow progression, the only definitive cure for adult craniofacial FD is ... | 2014-01-01 | |
| 43 |
 |
Olson, Randall J.; Spencer, Terrence S.; Mamalis, Nick | Three-year clinical comparison of 3-piece AcrySof and SI-40 silicone intraocular lenses | PURPOSE: To compare the 3-year performance of the 3-piece AcrySof (Alcon) and the SI-40 silicone (Allergan) intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: In this retrospective study, patients with no complications and at least a... | Acrylic Resins; Silicone Elastomers; Prosthesis Design; Postoperative Complications; Patient Satisfaction; Cataract | 2002-07 |
| 44 |
 |
Symons, John David | Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia | Elevation of plasma total homocysteine (tHcy) is associated with an increased risk of cardiovascular disease, but the underlying mechanisms are not well understood.1 Worldwide, the most common cause of mild hyperhomocysteinemia (HHcy) is deficiency of folate.2,3 Some4-8 but not all9,10 studies sugg... | Cystathionine B-synthase; Carotid artery; Aorta; Cardiovascular risk factors; Folate; Hyperhomocysteinemia; Arterial permeability; Arterial stiffness | 2006 |
| 45 |
 |
Rogers, Alan R. | Genetic variation at the MCIR Locus and the time since loss of human body hair | The melanocortin I receptor (MCIR) locus makes a protein that affects the color of skin and hair. At this locus, amino-acid differences are entirely absent among African humans, abundant among non-Africans (especially Europeans), and abundant in chimpanzee/human comparisons (Rana et al. 1999, Hardin... | Nonsynonymous; Chimpanzee; Constraint | 2004 |
| 46 |
 |
Ailion, David Charles; Morris, Alan H. | Determination of lung water content and distribution by nuclear magnetic resonance imaging | NMR imaging techniques are applicable to the assessment of lung water content and distribution because the NMR signal is, under certain conditions, proportional to tissue proton density. NMR imaging is noninvasive, easily repeatable, free from ionizing radiation, and particularly suitable for the as... | Water content | 1986 |
| 47 |
 |
Farmer, Colleen G. | The provenance of alveolar and parabronchial lungs: insights from paleoecology and the discovery of cardiogenic, unidirectional airflow in the American alligator (Alligator mississippiensis) | Birds and mammals evolved greater aerobic abilities than their common ancestor had. This required expansion of the cardiopulmonary system's capacity for gas exchange, but while directional selection for his expanded capacity resulted in extremely similar avian and mammalian hearts, strikingly differ... | 2010-07 | |
| 48 |
 |
Dailey, Andrew T. | Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 7: Lumbar fusion for intractable low-back pain without stenosis or spondylolisthesis | Establishing an appropriate treatment strategy for patients presenting with low-back pain, in the absence of stenosis or spondylolisthesis, remains a controversial subject. Inherent to this situation is often an inability to adequately identify the source of low-back pain to justify various treatmen... | 2014-01-01 | |
| 49 |
 |
Ehleringer, James R.; Rickart, Eric Allan; Dearing, Maria-Denise | Stable isotope ratios (?15N AND ?13C) of syntopic shrews (SOREX) | Local species richness in shrew (Soricidae) assemblages is often high, and the mechanisms of ecological separation remain relatively unexplored. In this study, hair samples from 6 species of Sorex in 3 separate assemblages were analyzed for stable carbon (13C/12C) and nitrogen (15N/14N) isotope rati... | 2004 | |
| 50 |
 |
Jorgensen, Erik | Axons break in animals lacking B-spectrin | Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break. | 2007 |