Filters: Collection: "ir_uspace"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 401 |
 |
Beckerle, Mary C. | Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression | Members of the cysteine-rich protein (CRP) family are evolutionarily conserved proteins that have been implicated in the processes of cell proliferation and differentiation. In particular, one CRP family member has been shown to be an essential regulator of cardiac and skeletal muscle development. | LIM domains; Chicken fibroblasts; Zyxin; Actinin; Protein expression; Cysteine-rich proteins | 1997 |
| 402 |
 |
Gardner, Reed M. | The Computer for Charting and Monitoring | Biomedical Informatics | 1993 | |
| 403 |
 |
Blumenthal, Donald K. | Effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding. | Using site-directed mutagenesis we have expressed in Escherichia coli three engineered calmodulins (CaM) containing deletions in the solvent-exposed region of the central helix. These are CaM delta 84, Glu-84 removed; CaM delta 83-84, Glu-83 and Glu-84 removed; and CaM delta 81-84, Ser-81 through Gl... | Drug Effects; Genetics; Metabolism | 1989-05-15 |
| 404 |
 |
Poulter, Charles Dale | Enzymes encoded by the farnesyl diphosphate synthase gene family in the big sagebrush Artemisia tridentata ssp. spiciformis | Farnesyl diphosphate synthase catalyzes the sequential head-to-tail condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate. In plants the presence of farnesyl diphosphate synthase isozymes offers the possibility of differential regulation. Three full-length cDNAs enc... | Amino Acid Sequence; Base Sequence; Molecular Sequence Data | 2003-08-22 |
| 405 |
 |
Mitchell, Joyce A. | Evaluating the informatics for integrating biology and the bedside system for clinical research | Background: Selecting patient cohorts is a critical, iterative, and often time-consuming aspect of studies involving human subjects; informatics tools for helping streamline the process have been identified as important infrastructure components for enabling clinical and translational research. We d... | 2009-01-01 | |
| 406 |
 |
Couldwell, William T. | History and evolution of transsphenoidal surgery | Initial attempts at transcranial approaches to the pituitary gland in the late 1800s and early 1900s resulted in a mortality rate that was generally considered prohibitive. Schloffer suggested the use of a transsphenoidal route as a safer, alternative approach to the sella turcica. He reported the f... | Neurosurgical history; Transsphenoidal surgery; Pituitary tumor | 2001 |
| 407 |
 |
Frederick, Jeanne M.; Thulin, Craig; Bernstein, Paul S. | Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye | Uptake, metabolism, and stabilization of xanthophyll carotenoids in the retina are thought to be mediated by specific xanthophyll-binding proteins (XBPs). A membrane-associated XBP was purified from human macula using ion-exchange chromatography followed by gel-exclusion chromatography. Two-dimensio... | Circular Dichroism; Isoelectric Focusing; Macula Lutea; Xanthophylls | 2004 |
| 408 |
 |
Battin, Margaret P. | Irony of supporting physician-assisted suicide: a personal account | Under other circumstances, I would have written an academic paper rehearsing the arguments for and against legalization of physician-assisted suicide: autonomy and the avoidance of pain and suffering on the pro side, the wrongness of killing, the integrity of the medical profession, and the risk of... | 2010-08 | |
| 409 |
 |
Francis, Leslie | Legal truth and moral realism | This January, the United States Supreme Court heard oral argument in appeals from two controversial "right to die" cases; decisions in the cases are expected by the end of the term.1 The Ninth Circuit case held that Washington's ban on assisted suicide, including physician-assisted suicide, violate... | Suicide; Dying; Ethics | 1997 |
| 410 |
 |
Margraf, Rebecca L.; Mao, Rong; Highsmith, W. Edward; Holtegaard, Leonard; Wittwer, Carl T. | Masking selected sequence variation by incorporating mismatches into melting analysis probes | Hybridization probe melting analysis can be complicated by the presence of sequence variations (benign polymorphisms or other mutations) near the targeted mutation. We investigated the use of 'masking' probes to differentiate alleles with similar probe melting temperatures. Selected sequence variati... | probe hybridization; high-resolution melting analysis; masking; RET | 2005-06-28 |
| 411 |
 |
Gerig, Guido | Multiscale medial shape-based analysis of image objects | Medial representation of a three-dimensional (3-D) object or an ensemble of 3-D objects involves capturing the object interior as a locus of medial atoms, each atom being two vectors of equal length joined at the tail at the medial point. Medial representation has a variety of beneficial properties,... | 2003-01-01 | |
| 412 |
 |
Poulter, Charles Dale; Davis, Darrell R. | 15N-labeled tRNA. Identification of dihydrouridine in Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR. | The N3 imino units of dihydrouridine were identified in samples of 15N-labeled Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR. The peaks for dihydrouridine had high field 1H (9.7-9.8 ppm) and 15N (147.8-149.5 ppm) chemical shifts. Assignments were made by 1H-15N chemic... | Hydrogen Bonding; Magnetic Resonance Spectroscopy; Magnetic Resonance Spectroscopy | 1986-03-15 |
| 413 |
 |
Battin, Margaret P. | A midwife through the dying process: stories of healing and hard choices at the end of life | In Timothy Quill's recounting of the deaths of nine patients, the final description is of the planned death of Jules: at home, surrounded by family members, and aided by a physician. It is a moving, true story, recounted in meticulous detail, from the first diagnosis to the final dose of barbiturat... | 1997 | |
| 414 |
 |
Warner, Homer R. | An Evaluation of Radiosulfate as a Granulocyte Label in the Dog | Biomedical Informatics | 1966 | |
| 415 |
 |
Bradshaw, Karen E. | Computer-Based Data Entry for Nurses in the ICU | Biomedical Informatics | 1989 | |
| 416 |
 |
Thomas, Kirk R.; Capecchi, Mario R. | High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. | Mutations were targeted to the Hprt locus in murine embryonic stem cells by using sequence replacement vectors. When the vector was designed such that the mutated sequences were flanked on both sides by several kilobases of DNA homologous to the target locus, replacement of chromosomal sequences wit... | Drug Resistance; Gene Rearrangement; Gentamicins | 1992-07 |
| 417 |
 |
Spencer S. Eccles Health Sciences Library, University of Utah | IAIMS Newsletter InfoFair 2000 Spring Supplement | The IAIMS Newsletter is published three times a year (August, January, May) with one InfoFair supplement and provides valuable information about Library activities and resources as well as informative articles related to information technology. | IAIMS | 2000-02-29 |
| 418 |
 |
Capecchi, Mario R. | In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells. | Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for future therapies based on cell replacement. The isolation of defined cell populations from a certain lineage or tissue is a prerequisite for the analysis of the potent... | Animals; Cell Differentiation; Cells, Cultured; Gene Transfer Techniques; Mice, Transgenic | 2005-10-23 |
| 419 |
 |
Macfarlan, Shane | Male Survival Advantage on the Baja California Peninsula | A consistent finding from contemporary Western societies is that women outlive men. However, what is unclear is whether sex differences in survival are constant across varying socio-ecological conditions. We test the universality of the female survival advantage with mortality data from a nineteenth... | ecology; health and disease and epidemiology; behaviour | 2020 |
| 420 |
 |
Battin, Margaret P.; Francis, Leslie; Jacobson, Jay A. | Patients' understanding and use of advance directives | The Patient Self-Determination Act was implemented in December 1991. Before and after its implementation, we used a structured interview of 302 randomly selected patients to determine their awareness, understanding, and use of advance directives. Implementation of the Act did not have a major eff... | Living will; Medical care; Durable power of attorney | 1994 |
| 421 |
|
Battin, Margaret P.; Jacobson, Jay A.; Francis, Leslie P. | Patients' understanding and use of advance directives | The Patient Self-Determination Act was implemented in December 1991. Before and after its implementation, we used a structured interview of 302 randomly selected patients to determine their awareness, understanding, and use of advance directives. Implementation of the Act did not have a major effec... | 1994 | |
| 422 |
 |
Christensen, Douglas A. | Planar waveguide biosensors for nucleic acid hybridization reactions | Oligonucleotide probes derived from (1) the T3 RNA polymerase promoter sequence (T3) and (2) prostate-specific antigen messenger RNA (PSA) were prepared and labeled with a red-emitting fluorescent dye (Cy5). The complimentary oligonucleotides (anti T3 and anti PSA) were prepared and labeled with bio... | Planar waveguides; Evanescence; Fluorescence; Glandular kallikrein; MDx; Molecular diagnostics; Nucleic acid; PSA; Oligonucleotide probes | 2000 |
| 423 |
 |
University of Utah. Spencer S. Eccles Health Sciences Library | IAIMS newsletter | The IAIMS Newsletter (1996-2005) provides valuable information about library activities and resources as well as informative articles related to information technology. | IAIMS | |
| 424 |
 |
Jorgensen, Erik | Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development | The neurotransmitter GABA has been proposed to play a role during nervous system development. We show that the Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase (GAD), the GABA biosynthetic enzyme. unc-25 is expressed specifically in GABAergic neurons. Null mutations in unc-25... | 1999 | |
| 425 |
 |
Beckerle, Mary C. | Cysteine-rich protein family of highly related LIM domain proteins | Here we describe a family of closely related LIM domain proteins in avian cells. The LIM motif defines a zinc-binding domain that is found in a variety of transcriptional regulators, proto-oncogene products, and proteins associated with sites of cell-substratum contact. One type of LIM-domain protei... | LIM domains; Chicken embryo fibroblasts; Quail embryo fibroblasts; Cell growth; Cell development; Cysteine-rich proteins | 1995 |