Filters: Collection: "ir_uspace"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 326 |
 |
Stoddart, Joan | Rethinking information delivery: using a natural language processing application for point-of-care data discovery | Objective: This paper examines the use of Semantic MEDLINE, a natural language processing application enhanced with a statistical algorithm known as Combo, as a potential decision support tool for clinicians. Semantic MEDLINE summarizes text in PubMed citations, transforming it into compact declarat... | 2012-01-01 | |
| 327 |
 |
Flynn, John J. | Orphan Drug Act: an unconstitutional exercise of the patent power | In 1983, Congress adopted the Orphan Drug Act (the "Act") pursuant to its power to regulate interstate and foreign commerce to stimulate research and development of drugs useful in treating relatively rare diseases.1 The cost of drug research and complying with the complex requirements for securing ... | Health Care; Drugs; Medicine; Medical treatment | 1992 |
| 328 |
 |
Coley, Phyllis D. | Antifungal depsidone metabolites from Cordyceps dipterigena, an endophytic fungus antagonistic to the phytopathogen gibberella fujikuroi | Among thirty four endophytic fungal strains screened for in vitro antagonism, the endophytic fungus Cordyceps dipterigena was found to strongly inhibit mycelial growth of the plant pathogenic fungus Gibberella fujikuroi. Two new depsidone metabolites, cordycepsidone A (1) and cordycepsidone B (2), w... | 2012 | |
| 329 |
 |
Paquette, Christina | Mediastinal pathologies presenting with unilateral vocal cord paralysis: hoarseness and the course of the reurrent laryngeal nerves | 2010-11-24 | ||
| 330 |
 |
Dailey, Andrew T. | Paragangliomas of the sellar region: report of two cases | TWO CASES OF paraganglioma arising from the parasellar region are presented. Both occurred in middle-aged women who sought treatment of headaches but who had no endocrinological dysfunction; one case was associated with ophthalmoplegia from cavernous sinus involvement. Diagnosis in both cases was ... | Paragangliomas; Sellar region; Parasellar region; Chemodectoma; Pituitary tumor | 1993 |
| 331 |
 |
Ailion, David Charles | Protein hydration changes in the formation of the nicotinamide adenine dinucleotide complexes of glyceraldehyde 3-phosphate dehydrogenase of yeast. II. The spin lattice relaxation of solvent water protons | The glyceraldehyde 3-phosphate dehydrogenase of yeast is known to undergo a particle volume contraction and the commensurate loss of a hydration component when it forms a complex with NAD. We have inquired whether the water movement in the conformational transition can be monitored by measurements ... | Protein hydration; Nicotinamide adenine dinucleotide complexes; Glyceraldehyde 3 phosphate dehydrogenase; Solvent water protons | 1973 |
| 332 |
 |
Tasdizen, Tolga | Segmentation of haematopoeitic cells in bone marrow using circle detection and splitting techniques | Bone marrow evaluation is indicated when peripheral blood abnormalities are not explained by clinical, physical, or laboratory findings. In this paper, we propose a novel method for segmentation of haematopoietic cells in the bone marrow from scanned slide images. Segmentation of clumped cells is a ... | 2012-01-01 | |
| 333 |
 |
Beckerle, Mary C. | Characterization of the interaction between zyxin and members of the Ena/Vasodilator-stimulated Phosphoprotein family of proteins | Zyxin contains a proline-rich N-terminal domain that is similar to the C-terminal domain in the ActA protein of the bacteria, Listeria monocytogenes. We screened the entire amino acid sequence of human zyxin for Menainteracting peptides and found that, as with ActA, proline-rich sequences were the s... | Zyxin; Actin; Listeria monocytogenes; Proline-rich repeats; Cell spreading | 2000 |
| 334 |
 |
Wu, Yong-Shi | Identification of androgen response elements in the insulin-like growth factor I upstream promoter | Testosterone stimulates the expression of IGF-I in cells and tissues that include prostate, muscle and muscle satellite cells, and the uterus. Here, the molecular mechanisms of this effect of testosterone were explored. Testosterone increased IGF-I mRNA levels in HepG2 and LNCaP cells and stimulated... | IFG-I; Androgen-responsive elements | 2007 |
| 335 |
 |
Capecchi, Mario R. | Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma | Angiotensin-converting enzyne (ACE) is a pepitdase responsible for the cleavage of angiotensin I and Several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10... | Macrophage enzyme; Melanoma resistance; Enhanced macrophage angiotensin-converting enzyme | 2007 |
| 336 |
 |
Beckerle, Mary C. | Purification and characterization of an α-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation | α-Actinin is required for the organization and function of the contractile machinery of muscle. In order to understand more precisely the molecular mechanisms by which α-actinin might contribute to the formation and maintenance of the contractile apparatus within muscle cells, we performed a scree... | LIM domains; Z-disc; Actin; Actinin-associated LIM proteins; PDZ-LIM protein | 1999 |
| 337 |
 |
Hansen, Charles D. | Reconstruction and visualization of planetary nebulae | Abstract-From our terrestrially confined viewpoint, the actual three-dimensional shape of distant astronomical objects is, in general, very challenging to determine. For one class of astronomical objects, however, spatial structure can be recovered from conventional 2D images alone. So-called planet... | 2005-09 | |
| 338 |
 |
Olivera, Baldomero M. | Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors | Background: Can dicarba bridges (stapling) replace noncovalent interactions that stabilize helical conformation of neuroactivepeptides? Results: A rational design, synthesis, structural, and functional characterization of stapled conG analogs that target NMDAreceptors is reported. Conclusion: Staple... | 2012-01-01 | |
| 339 |
 |
Beckerle, Mary C. | Targeting of zyxin to sites of actin membrane interaction and to the nucleus | The localization of proteins to particular intracellular compartments often regulates their functions. Zyxin is a LIM protein found prominently at sites of cell adhesion, faintly in leading lamellipodia, and transiently in cell nuclei. Here we have performed a domain analysis to identify regions in ... | Zyxin; Actin; LIM domains; Focal adhesions; Lamellipodia; Cytoskeletal architecture | 2001 |
| 340 |
 |
Bernstein, Paul S. | Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models | PURPOSE: To determine the stereochemistry of carotenoids in human ocular tissues in comparison with plasma and liver and to elucidate the possible transformations of dietary (3R,3'R,6'R)-lutein and (3R,3'R)-zeaxanthin in the eye. Similarly, to characterize the carotenoid profiles in the eye tissues,... | Chromatography, High Pressure Liquid; Stereoisomerism; Xanthophylls | 2002 |
| 341 |
 |
Couldwell, William T. | Zones of approach for craniofacial resection: minimizing facial incisions for resection of anterior cranial base and paranasal sinus tumors | Anterior cranial base tumors are surgically resected with combined craniofacial approaches that frequently involve disfiguring facial incisions and facial osteotomies. The authors outline three operative zones of the anterior cranial base and paranasal sinuses in which tumors can be resected with th... | Anatomic study; Anterior cranial base; Cranial base surgery; Craniofacial surgery; Minimally invasive | 2003 |
| 342 |
 |
Rogers, Alan R.; Jorde, Lynn B. | Genetic structure of the Utah Mormons: comparison of results based on RFLPs, blood groups, migration matrices, isonymy, and pedigrees | The genetic structure of the Utah Mormon population is examined using 25 blood group and 47 RFLP alleles obtained from 442 subjects living in 8 geographic subdivisions. Nei's Gst was 0.013 (p < 0.002) for the RFLP data and 0.012 (p > 0.4) for the blood group data, showing that only 1% of the geneti... | 1994 | |
| 343 |
 |
Seyedhosseini Tarzjani, Seyed Mojtaba | Image segmentation with cascaded hierarchical models and logistic disjunctive normal networks | Contextual information plays an important role in solving vision problems such as image segmentation. However, extracting contextual information and using it in an effective way remains a difficult problem. To address this challenge, we propose a multi-resolution contextual framework, called cascade... | 2013-01-01 | |
| 344 |
 |
Wen, Ming | Immigrant perceptions of discrimination in health care: the California Health Interview Survey 2003 | The 2002 Institute of Medicine (IOM) report Unequal Treatment summarized research on racial and ethnic disparities in health care defined as "racial or ethnic differences in the quality of healthcare that are not due to access-related factors or clinical needs, preferences, and appropriateness of i... | Health care; California health interview survey; Health disparities; Healthcare disparities | 2006 |
| 345 |
 |
Haber, Matthew | In defense of the organism: Thomas Pradeu (Elizabeth Vitanza, trans.): The limits of the self: immunology and biological identity. New York: Oxford University Press, 2012, ix+302 pp, ISBN: 978-0-19-977528-6, $65 HB. | Thomas Pradeu's The Limits of the Self provides a precise account of biological identity developed from the central concepts of immunology. Yet the central concepts most relevant to this task (self and nonself ) are themselves deemed inadequate, suffering from ambiguity and imprecision. Pradeu seeks... | 2014-01-01 | |
| 346 |
 |
Utz, Rebecca L. | Procedure to correct proxy-reported weight in the National Health Interview Survey, 1976-2002 | Background: Data from the National Health Interview Survey (NHIS) show a larger-than-expected increase in mean BMI between 1996 and 1997. Proxy-reports of height and weight were discontinued as part of the 1997 NHIS redesign, suggesting that the sharp increase between 1996 and 1997 may be artifactua... | National Health Interview Survey; NHIS; Proxy-reported weight | 2009 |
| 347 |
 |
Mitchell, Joyce A. | Using information prescriptions to refer patients with metabolic conditions to the Genetics Home Reference website | Objectives: The objectives of this study were to assess the reactions of adult patients and parents of children with metabolic conditions to receipt of an ‘‘information prescription'' (IP) to visit Genetics Home Reference (GHR), a National Institutes of Health/National Library of Medicine online... | 2011-01-01 | |
| 348 |
 |
Hansen, Mark S.; Healy, Lindsey J.; Johnson, Christopher R.; Capecchi, Mario R.; Keller, Charles; Jones, Greg M. | Virtual histology of transgenic mouse embryos for high-throughput phenotyping. | A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology for phenotypic assessment of mouse ... | Forkhead Transcription Factors; Paired Box Transcription Factors | 2006 |
| 349 |
 |
McDaniel, Susan | Challenges to health promotion among older working women | The work site, has, been a place of successful health promotion among; certain groups, most notably men in management. The potential of work site health promotion among women, particularly among' older working women, remains unexplored.. Given women's greater longevity and women's likelihood of spen... | Workers; Longevity; Aging | 1988 |
| 350 |
 |
Mitchell, Joyce A. | Evidence-based retrieval in evidence-based medicine | Objective: Clinical decisions based on a meta-analysis that is based on an ineffective retrieval strategy may have serious negative consequences for patients. The study objective was to investigate the extent to which meta-analyses report proof of their retrieval strategies' effectiveness. Methods: ... | 2004-01-01 |