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1 Couldwell, William T.Metabolic syndrome: what neurosurgeons should knowThe term metabolic syndrome, first introduced in 1988, has evolved in concept since that time. While the strict definition is subject to ongoing debate, the syndrome generally involves glucose intolerance, obesity, dyslipidemia and high blood pressure, which increase the risk of developing cardiovas...2008-01-01
2 Ehleringer, James R. ; Cerling, Thure E.Aberrant water homeostasis detected by stable isotope analysisWhile isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at natural abundance levels. The isotopic composition...2010-07-21
3 Singleton, J. Robinson; Smith, A. GordonMicrovascular complications of impaired glucose tolerance.Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts both large- and small-vessel vascular complications, independent of a patient's progression to diabetes. Patients with IGT are at significantly increased risk for death and morbidity due to myocardia...Microcirculation; Humans2003-12-01
4 LaStayo, Paul C.Intermuscular fat: a review of the consequences and causesMuscle's structural composition is an important factor underlying muscle strength and physical function in older adults. There is an increasing amount of research to support the clear disassociation between the loss of muscle lean tissue mass and strength with aging. This disassociation implies that...2014-01-01
5 Shaw, Janet M.; Moyer-Mileur, Laurie L.The new glucose revolution: is the authoritative guide to the glycemic index the right dietary solution for lifelong health?The persistence of an epidemic of obesity, coronary heart disease and type 2 diabetes suggests that new nutritional strategies are needed if the epidemic is to be overcome. A promising nutritional approach suggested by this thematic review is carbohydrate restriction. Under conditions of carbohydra...2010
6 Kowalski, Christopher Aaron; Deesing, Michole Ann; Deeter, Nicholas B.; Symons, John DavidCeramide-induced disruption of endothelial nitric oxide synthase dimerization in bovine aortic endothelial cells (BAECs) is not secondary to peroxynitrite formationAn estimated 23.6 million individuals in the United States have diabetes and of those 90-95% have type II diabetes. Cardiovascular complications (e.g., hypertension and vascular dysfunction) are four-fold more prevalent in patients with type II diabetes. To gain insight into mechanisms responsib...Ceramide-induced disruption; Nitric oxide synthase dimerization; Bovine aortic endothelial cells; BAEC; Peroxynitrite formation; Trapeze Interactive Poster2010-01-20
7 Brillinger, AnneDiet; If you go "On" a diet, you're bound to go "OffIf you go "ON" a diet, you're bound to go "OF". Diet is a four-letter word. Just ask the millions of frustrated overweight Americans who've struggled to stay on one. Making fairly simple lifestyle changes can improve how you feelDiet; Bioelectrical Impedance Analysis; Body Mass Index; Food Guide Pyramid2000-03
8 Symons, John DavidCeramide-induced disruption of endothelial nitric oxide synthase dimerization in bovine aortic endothelial cells (BAECs) is not secondary to peroxynitrite formationAn estimated 23.6 million individuals in the United States have diabetes and of those 90-95% have type II diabetes. Cardiovascular complications (e.g., hypertension and vascular dysfunction) are four-fold more prevalent in patients with type II diabetes.1 The mechanism(s) responsible for increased s...2010-01-01
9 Research in brief: Spring 2005Summaries of Selected Research Projects at the University of Utah Health Sciences CenterResearch: School of Medicine, College of Pharmacy;, College of Nursing, College of Health2005-03
10 Owen, William E.; Roberts, William L.Effects of hemoglobin (Hb) E and HbD traits on measurements of glycated Hb (HbA1c) by 23 methods.Glycohemoglobin (GHB), reported as hemoglobin (Hb) A1c, is a marker of long-term glycemic control in patients with diabetes and is directly related to risk for diabetic complications. HbE and HbDare the second and fourth most common Hb variants worldwide. We investigated the accuracy of HbA1c measur...Glycohemoglobin; GHB; Glycated Hb; Glycemic control2008
11 Adler, Frederick R.Long-term models of oxidative stress and mitochondrial damage in insulin resistance progressionInsulin resistance, characterized by a reduced cellular response to insulin, is a major factor in type 2 diabetes pathogenesis, with a complex etiology consisting of a combination of environmental and genetic factors. Oxidative stress, which develops through an accumulation of toxic reactive oxygen ...2014-01-01
12 Symons, John DavidInfluence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemiaElevation of plasma total homocysteine (tHcy) is associated with an increased risk of cardiovascular disease, but the underlying mechanisms are not well understood.1 Worldwide, the most common cause of mild hyperhomocysteinemia (HHcy) is deficiency of folate.2,3 Some4-8 but not all9,10 studies sugg...Cystathionine B-synthase; Carotid artery; Aorta; Cardiovascular risk factors; Folate; Hyperhomocysteinemia; Arterial permeability; Arterial stiffness2006
13 Hunt, Steven C.Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries: The NHLBI Family Heart StudyBackground and Aims: Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, lim...2014-01-01
14 Dwan, JohnIgnored medical problemA physician who doesn't recommend that a patient stop smoking is hard to find. Few, however, try to help patients lose weight, even though a recent National Institutes of Health (NIH) study showed that at least 300,000 deaths each year can be attributed to being overweight, obese or severely overwei...Diet; Life Style; Therapeutic Aspects; Science of nutrition2000-03
15 Cashdan, Elizabeth A.Waist-to-hip ratio across cultures: trade-offs between androgen- and estrogen-dependent traitsA gynoid pattern of fat distribution, with small waist and large hips (low waist-to-hip ratio, or WHR) holds significant fitness benefits for women: women with a low WHR of about 0.7 are more fecund, are less prone to chronic disease, and (in most cultures) are considered more attractive. Why, then...Fat distribution; Gynoid pattern; Body types; Waist-to-hip ratio; WHR2008
16 Cashdan, Elizabeth A.Waist-to hip ratio across cultures: trade-offs between androgen-and estrogen-dependent traitsA gynoid pattern of fat distribution, with small waist and large hips (low waist-to-hip ratio, or WHR) holds significant fitness benefits for women: women with a low WHR of about 0.7 are more fecund, are less prone to chronic disease, and (in most cultures) are considered more attractive. Why, then...Fertility; Optimum; Fecundity2008
17 Agarwal, NiveditaBrain function monitoring during off-pump cardiac surgery: a case reportBackground: Early postoperative stroke is an adverse syndrome after coronary bypass surgery. This report focuses on overcoming of cerebral ischemia as a result of haemodynamic instability during heart enucleation in off-pump procedure. Case presentation: A 67 year old male patient, Caucasian race, ...2008
18 Murphy, Patricia A.Extended and continuous combined contraceptive regimens for menstrual suppressionMany women have medical indications for menstrual suppression or a personal preference to reduce or eliminate monthly bleeding, which can be achieved with extended and continuous regimens of combined estrogen and progestin contraceptives. Combined contraceptives are traditionally administered in a 2...2012-01-01
19 Smith, Ken R.A population-based study of childhood cancer survivors body mass indexPopulation-based studies are needed to estimate the prevalence of underweight or overweight/obese childhood cancer survivors. Procedure. Adult survivors (diagnosed ≤20 years) were identified from the linked Utah Cancer Registry and Utah Population Database. We included survivors currently aged ≥...2014-01-01
20 Varner, Michael W.Human placental lactogen and other placental proteins as indicators of fetal well-being.The purpose of this article will be to review the role of hPL and the newer hormones as indicators of fetal well-being.Human Placental Lactogen; Pregnancy Proteins; Indicators of Fetal Well-Being1982-12
21 Research in brief: Winter 2005Summaries of Selected Research Projects at the University of Utah Health Sciences CenterResearch: School of Medicine, College of Pharmacy;, College of Nursing, College of Health2005-12
22 Couldwell, William T.Sellar and parasellar metastatic tumorsThe sellar and parasellar (SPS) region is a complex area rich in vital neurovascular structures a first manifestation of a systemic malignancy. Metastases to this region are rare; breast cancer is the most common source among those that metastasize to the SPS region. Ophthalmoplegia, headache, retro...2012-01-01
23 Hunt, Steven C.; Adams, Ted; Hopkins, Paul N.; Hunt, Steven C.ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetesAdipose triglyceride lipase (ATGL) was recently described to predominantly perform the initial step in triglyceride hydrolysis and therefore seems to play a pivotal role in the lipolytic catabolism of stored fat in adipose tissue. In the first study investigating genetic variations within the ATGL g...Diabete, Type 2; ATGL; Fat; Triglycerides2006
24 Capecchi, Mario R.Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironmentAlveolar soft part sarcoma (ASPS), a deadly soft tissue malignancy with a predilection for adolescents and young adults, associates consistently with t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3. We proved the oncogenic capacity of this fusion gene by driving sarcomagenesis in m...2014-01-01
25 LaStayo, Paul C.Resistance exercise with older fallers: Its impact on intermuscular adipose tissueObjective. Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with ecce...2014-01-01
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