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1 Bastiani, MichaelLoss of axons in the cat optic nerve following fetal unilateral enucleation: an electron microscopic analysisBetween the 48th day of gestation (E-48) and maturity, the number of axons in the cat optic nerve is reduced by approximately 50%. On the basis of an electron microscopic assay, the axon population of the E-48 nerve was estimated to be 328,000. In contrast, estimates from two normal adults were 159,...Ganglion cell death; Retinofugal projection; Retinal ganglion cell axons1983
2 Creel, Donnell J.; Leventhal, Audie G.Retinal projections in tyrosinase-negative albino catsRetinal projections were examined in two tyrosinase-negative albino cats using autoradiographic techniques. Cats from this colony have pink eyes; their retinal pigment epithelium, ciliary body, and iris epithelium are completely devoid of melanin pigment. Test breeding for five generations indicates...Cats; Albinism; Vision; Autoradiography; Retina1982-07
3 Goller, FranzVibratory behavior of the sound generating structures of the bird syrinxRecent endoscopic studies of the bird syrinx during phonation suggest that sound is generated by vibrating membrane folds or labia (Goller and Larsen, J. exp. Biol., 200, 2165-2176, 1997; Goller and Larsen, Proc. Natl. Acad. Sci., 4,14787-14791, 1997) and not by a whistle mechanism (Nottebohm, J. ...Vocalization; Vibration detector; Whistle mechanism1998
4 Dawkins, Beverly AnnThe embryonic development of the California GullThe California gull (Larus califomicus) is a summer resident in Utah nesting commonly on certain islands in Great Salt Lake as well as at man-made refuges on the east side of the lake. Many aspects of the biology of the species have been investigated (Beck, 1942; Behle, 1958; Behle and Goates, 1957;...1965-12-03
5 Angelucci, AlessandraExperimentally induced retinal projections to the ferret auditory thalamus: development of clustered eye-specific patterns in a novel targetWe have examined the relative role of afferents and targets in pattern formation using a novel preparation, in which retinal projections in ferrets are induced to innervate the medial geniculate nucleus (MGN). We find that retinal projections to the MGN are arranged in scattered clusters. Clusters a...Retina; Ferrets1997
6 Couldwell, William T.; Apfelbaum, Ronald I.Decompression of cavernous sinus meningioma for preservation and improvement of cranial nerve functionMeningiomas are the most common tumors affecting the cavernous sinus (CS). Despite advances in microsurgery and radiosurgery, treatment of CS meningiomas remains difficult and controversial. As in cases of other meningiomas, the goal of treatment for CS meningioma is long-term growth control and pre...2006-07
7 Couldwell, William T.Photophobia in a blind patient: an alternate visual pathwayPhotophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from mult...2006-11
8 Digre, Kathleen B.; Couldwell, William T.; Amini, AminPhotophobia in a blind patient: An alternate visual pathway. Case report.Photophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from multi...Photophobia, Blindness, Signaling Pathway, Pretectal Nuclei, Trigeminal Pathway2006-12-14
9 Couldwell, William T.Ventroposterior medial pallidotomy in patients with advanced Parkinson's diseaseIN A PRELIMINARY study, the effects of ventroposterior medial pallidotomy were evaluated in five patients with advanced Parkinson's disease in whom medical therapy had failed. The mean age was 67.0 ? 5.6 years, and t h e mean Hoelin and Yahr stage when "off" was 3.9 ? 1.3. Three patients received u...Pallidotomy; Dyskinesia; Stereotaxy; Postoperative morbidity1995
10 Kestle, John R. W.; Brockmeyer, Douglas LeeCranial base strategies for resection of craniopharyngioma in childrenThe optimal treatment of craniopharyngioma in children remains a challenge. The use of complete excision to minimize recurrence continues to be controversial because of the risk of postoperative morbidity and death. Advances in skull base approaches, modern microsurgical techniques, neuroimaging, an...Craniopharyngioma; Surgical approach; Skull base surgery2005
11 Couldwell, William T.Pituitary apoplexy: diagnosis and managementPituitary apoplexy, an uncommon complication of pituitary adenomas, was first decribed in 1898 when pearce Bailey reported hemorrhage into a pituitary adenoma in a 50 year old man with acromegaly. The patient presented with sudden onset of headache, nausea, vomiting, fever, oculomotor palsies, and v...Pituitary Apoplexy; Pituitary adenoma; Transsphenoidal surgery2003
12 House, Paul A.; Couldwell, William T.De novo fenestration of the optic nerve case illustration.Fenestration of the optic nerve or chiasm due to the presence of aneurismal dilation of the internal carotid artery (ICA) has been described. In three out of five cases reviewed recently, the optic nerve was penetrated by an ICAΓÇôophthalmic artery aneurysm.3 Penetration of the optic nerve was du...Aneurysm; Congenital Optic Nerve2005-02-01
13 Bastiani, MichaelGuidance of neuronal growth cones in the grasshopper embryo. II. Recognition of a specific axonal pathway by the aCC neuronIn the previous paper, we experimentally analyzed the selective affinity of the pCC growth cone for the MP1/dMP2 fascicle in the grasshopper embryo. Here we describe a similar experimental analysis demonstrating the selective affinity of the aCC growth cone for the U fascicle. These results support...Axon; Cell; Fascicle1986
14 Normann, Richard A.Oscillations in rod and horizontal cell membrane potential: evidence for feed-back to rods in the vertebrate retina1. Rods and horizontal cells were studied with intracellular recordings in the retina of the toad, Bufo marinus; 161 cells were from the eyecup preparation and thirty were from the isolated perfused retina. 2. Of these cells, 39% exhibited either transient or sustained oscillations of membrane poten...Retina; Photoreceptors; Toads; Adaptation, Ocular1976
15 Couldwell, William T.William Osler at McGill University: the baby professor and his early contributions to neurosurgeryBetween 1870 and 1884, as both a medical student and a member of the faculty, Sir William Osler performed approximately 1000 postmortem examinations at McGill University in Montreal. He conducted 786 of these examinations during his 7 years (1877-1884) of service as a pathologist at the M were caref...2004-10
16 Bastiani, MichaelPathfinding by neuronal growth cones in grasshopper embryos: II. Selective fasciculation onto specific axonal pathwaysIn the previous paper (Raper, J. A., M. Bastiani, and C. S. Goodman (1983) J. Neurosci. 3: 20-30) we showed that the growth cones of two sibling neurons, the G and C cells, follow the same route in the developing grasshopper neuropil until they reach a stereotypic choice point. Here their growth con...Neurons; Axons; Neuropil1983
17 Gerig, GuidoTemporal and spatial development of axonal maturation and myelination of white matter in the developing brainBACKGROUND AND PURPOSE-Diffusion tensor imaging (DTI) has been widely used to investigate the development of white matter (WM). However, information about this development in healthy children younger than 2 years of age is lacking, and most previous studies have only measured fractional anisotropy (...2009-01-01
18 Digre, Kathleen B.; Gouw, Launce G.; Harris, Catherine P.; Haines, John H.; Ptacek, L.J.Autosomal dominant cerebellar ataxia with retinal degeneration: clinical, neuropathologic, and genetic analysis of a large kindred.The autosomal dominant cerebellar ataxias (ADCA) comprise a heterogeneous group of neurologic disorders characterized by degeneration of the cerebellum, spinal cord, and brainstem. Genetic analysis has revealed two loci, SCA1 on chromosome 6p, and SCA2 on chromosome 12q, responsible for some ADCA. W...Retinal Degeneration; Cerebellar Ataxia; Genetic Analysis1994-08
19 Yamaguchi, AyakoDevelopment of an acute method to deliver transgenes into the brains of adult Xenopus laevisThe central vocal pathway of the African clawed frog, Xenopus laevis, is a powerful vertebrate model to understand mechanisms underlying central pattern generation. However, fast and efficient methods of introducing exogenous genes into the neurons of adult X. laevis are currently not available. Her...viral vector; vesicular stomatitis virus; Xenopus laevis; transgene; neurons; vocalizations; central pattern generator; electroporation2018
20 Couldwell, William T.; Chin, Steven S.Extranodal NK/T-cell lymphoma presenting as a pituitary massExtranodal NK/T-cell lymphomas are uncommon neoplasms that are highly aggressive and show a strong association with Epstein-Barr virus. They most commonly affect the nasal cavity and paranasal sinuses; manifestation as a primary pituitary tumor has never been described. The authors report a case of ...2007-09
21 Varner, Michael W.Physiologic changes in pregnancy: surgical implications.Pregnancy has measurable effects on essentially every organ system in a woman's body. An understanding of these changes is vital for determining what is normal or abnormal in a pregnant woman. These changes frequently alter symptoms and signs of surgical diseases during pregnancy. In addition, ma...Pregnancy; Physiologic Changes; Surgical Implications1994-06
22 Hansen, Charles D.; Chien, Chi-BinInteractive visualization tool for multi-channel confocal microscopy data in neurobiology researchConfocal microscopy is widely used in neurobiology for studying the three-dimensional structure of the nervous system. Confocal image data are often multi-channel, with each channel resulting from a different fluorescent dye or fluorescent protein; one channel may have dense data, while another has ...Volume rendering; Zebrafish2009-11
23 Gerig, GuidoMultivariate Modeling of longitudinal MRI in early brain development with confidence measuresThe human brain undergoes rapid organization and structuring early in life. Longitudinal imaging enables the study of these changes over a developmental period within individuals through estimation of population growth trajectory and its variability. In this paper, we focus on maturation of white an...2013-01-01
24 Evans, DavidGraphical man/machine communications: December 1971Semi-Annual Technical Report for period 1 June 1971 to 31 December 1971. This document includes a summary of research activities and facilities at the University of Utah under Contract F30602-70-C-0300. Information conveys important research milestones attained during this period by each of the f...Man/machine communications; Computing systems; Digital waveform processing1971-12
25 Dailey, Andrew T.Modulation of macrophage and microglial responses to axonal injury in the peripheral and central nervous systemsOBJECTIVE: After axonal injury, macrophages rapidly infiltrate and become activated in the mammalian peripheral nervous system (PNS) but not the central nervous system (CNS). We used the dorsal root pathway to study factors that modulate the response of macrophages to degenerating axons in both the ...Axonal injury; Macrophage response; Microglial response; Peripheral nervous system; Lewis rats1999
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