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1 Petti, Cathy A.Role of the laboratory in diagnosis of influenza during seasonal epidemics and potential pandemicsLaboratory diagnosis of influenza is critical to its treatment and surveillance. With the emergence of novel and highly pathogenic avian influenza viruses, the role of the laboratory has been further extended to include isolation and subtyping of the virus to monitor its appearance and facilitate ap...Antibodies, Viral; Antigens, Viral; RNA, Viral2006
2 Adler, Frederick R.Effect of 1918 PB1-F2 expression on influenza A virus infection kineticsRelatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alters viral po...2011
3 Adler, Frederick R.Effect of 1918 PB1-F2 expression on influenza A virus infection kineticsAbstract Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alter...2011
4 Capecchi, Mario R.Measurement of suppressor transfer RNA activity.Transfer RNA (tRNA) suppression of nonsense mutations in prokaryotic systems has been widely used to study the structure and function of different prokaryotic genes. Through genetic engineering techniques, it is now possible to introduce suppressor (Su+) tRNA molecules into mammalian cells. A quanti...Animals; Cells, Cultured; Eukaryotic Cells; Genes, Viral; Mice; Orthomyxoviridae; Peptide Chain Termination, Translational; Protein Biosynthesis1983-08-26
5 Capecchi, Mario R.Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells.We have used site-specific mutagenesis to change the anticodon of a Xenopus laevis tyrosine tRNA gene so that it would recognize ochre codons. This tRNA gene is expressed when amplified in monkey cells as part of a SV40 recombinant and efficiently suppresses termination at both the ochre codon separ...Xenopus; Nucleic Acid Conformation; Kidney; DNA Restriction Enzymes1984-11
6 Kriesel, John D.; Spruance, Spotswood L.; Daynes, Raymond A.Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease.Nucleic acid vaccinations with plasmids pWW65, containing the sequence for herpes simplex type 2 (HSV-2) gD2, and pRSVnt, lacking the gD sequence, were studied. Groups of mice were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt. Clinical disease (vaginitis), serum an...Mice, Inbred BALB C; Plasmids; Viral Vaccines1996
7 Myntti, JeremySaving Stories & Lives Using the LibraryPresentation given for a University of Utah Alumni Association Webinar2020-06-12
8 Smith, Ken R.; Bean, Lee Lawrence; Mineau, Geraldine Page; Fraser, Alison M.; Lane, DianaInfant deaths in Utah, 1850-1939Of all the health revolutions that have taken place in the United States since 1850, the reduction of infant mortality is arguably the most dramatic and far-reaching. Because of the incompleteness and unreliability of surviving vital records,, we will probably never know precisely the rate of infan...Death; Utah; Infant mortality2002
9 Frederick, Jeanne M.Inhibitors of metalloendoprotease activity prevent K+-stimulated neurotransmitter release from the retina of Xenopus laevis.Metalloendoprotease activity was identified in retinal homogenates using a synthetic fluorogenic metalloendoprotease substrate and specific metalloendoprotease inhibitors. The requirement of metalloendoprotease activity in neurotransmitter release was examined during the depolarization-induced relea...Neuromuscular Junction; Neurotransmitter Agents; Membrane Fusion1984
10 Petti, Cathy A.; Polage, Christopher R.Assessment of the utility of viral culture of cerebrospinal fluidNucleic acid amplification testing is the preferred method to detect enteroviruses and Herpesviridae in cerebrospinal fluid, but clinicians still request viral culture. Review of 22,394 viral cultures of cerebrospinal fluid samples found that <0.1% recovered nonenterovirus, non-Herpesviridae species...Enterovirus Infections; Herpesviridae Infections; Virus Cultivation2006-12-15
11 Adler, Frederick R.A time since recovery model with varying rates of loss of immunityFor many infectious diseases, immunity wanes over time. The majority of SIRS models assume that this loss of immunity takes place at a constant rate. We study temporary immunity within a SIRS model structure if the rate of loss of immunity can depend on the time since recovery from disease.We determ...2012-01-01
12 Adler, Frederick R.Do rhinoviruses follow the neutral theory? The role of cross-immunity in maintaining the diversity of the common coldOver 100 serotypes of rhinoviruses, one of the primary causes of the common cold, co-circulate in the human population. This high diversity makes it effectively impossible to develop a vaccine, even for those at risk of complications due to asthma or cystic fibrosis.Serotypes; mutation rate; immunodominance2006
13 Adler, Frederick R.Mathematical model of a three-stage innate immune response to a pneumococcal lung infectionPneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease. We combine bacterial titer measurements from mice infected with Streptococcus pneumoniae with mat...2011
14 Adler, Frederick R.Mathematical modeling the age dependence of Epstein-Barr virus associated infectious mononucleosisMost people get Epstein-Barr virus (EBV) infection at young age and are asymptomatic. Primary EBV infection in adolescents and young adults however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue, and sore throat that can persist for months. Expansion in the numb...2011
15 Mitchell, Joyce A.The columbia registry of controlled clinical computer trialsNumerous reports on randomized controlled clinical trials of comnputer-based interventions have been published. These trials provide useful evaluations of the impact of information technology on patient care. Unfortunately, several obstacles make access to the trial reports difficult. Barriers inclu...1992-01-01
16 Adler, Frederick R.Mathematical modeling the age dependence of Epstein-Barr virus associated infectious mononucleosisMost people get Epstein-Barr virus (EBV) infection at young age and are asymptomatic. Pri-mary EBV infection in adolescents and young adults however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue, and sore throat that can persist for months. Expansion in the num...2012
17 Kriesel, John D.; Maulden, Sarah Annamarie; Spruance, Spotswood L.Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation.Herpes simplex viruses (HSVs) infect epithelial cells, become localized in neurons, and can reactivate in response to a variety of stimuli, including ultraviolet light and hyperthermia. The sequence of gene activation during viral replication is known, but the molecular linkage between exogenous sti...Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Virus Activation1997
18 Gardner, Reed M.Measuring the Value of Information SystemsBiomedical Informatics1984
19 Hymas, Weston C.; Hillyard, David R.Description and validation of a novel real-time RT-PCR enterovirus assayEnteroviruses are a leading cause of aseptic meningitis in adult and pediatric populations. We describe the development of a real-time RT-PCR assay that amplifies a small target in the 5' nontranslated region upstream of the classical Rotbart enterovirus amplicon. The assay includes an RNA internal ...RT-PCR enterovirus assay; Rotbart enterovirus amplicon; Aseptic meningitis2008
20 Mitchell, Joyce A.Quality evaluation of controlled clinical information service trialsRandomized controlled clinical trials are increasingly accepted as tools of computer technology assessment and, therefore, quality evaluation of trials has great theoretical and practical significance. The purpose of this study was to assist the design of evaluation studies and synthesis of publishe...1993-01-01
21 Adler, Frederick R.Effects of intraspecific density-dependence on species richness and species abundance distributionsAbstract Species richness and patterns of abundance result from the interplay between niche differences, realized as intraspecific density-dependence (IDD), and so-called neutral processes that arise when species fitnesses are similar. This paper presents an extension of neutral models that incorpo...2010
22 Warner, Homer R.A Computer-Directed Patient History: Functional Overview and Initial ExperienceBiomedical Informatics1986
23 Warner, Homer R.Odyssey: A Program to Access Medical KnowledgeBiomedical Informatics1987
24 Gerig, GuidoSynergy of image analysis for animal and human neuroimaging supports translational research on drug abuseThe use of structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in animal models of neurophysiology is of increasing interest to the neuroscience community. In this work, we present our approach to create optimal translational studies that include both animal and human neu...2011-01-01
25 Jayamohan, HarikrishnanAdvances in microfluidics and lab on a chip technologiesAdvances in molecular biology are enabling rapid and efficient analyses for effective intervention in domains like biology research, infectious disease management, food safety and bio-defense. The emergence of microfluidics and nanotechnologies has enabled both new capabilities and instrument sizes ...Microfluidics; Lab on a chip; Point of care; PCR; Isothermal amplification; High resolution melting analysis; Cytogenetics; Protein detection; Next generation sequencing; Sample preparation; Library preparation; Cell sorting2017
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