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Hawkes, Kristen | A reappraisal of grandmothering and natural selection | Kachel et al. [1] conclude from simulations of their agent-based model that fitness benefits from helpful grandmothers do not select for increased longevity. We studied their assumptions and model, ran further simulations and found flaws that are fatal to their test. Here, we explain four problems a... | 2011-01-01 | |
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Gerig, Guido | Abnormal brain synchrony in down syndrome | Down Syndrome is the most common genetic cause for intellectual disability, yet the pathophysiology of cognitive impairment in Down Syndrome is unknown. We compared fMRI scans of 15 individuals with Down Syndrome to 14 typically developing control subjects while they viewed 50 min of cartoon video c... | 2013-01-01 | |
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Awasthi, Manu; Nellans, David W.; Sudan, Kshitij; Balasubramonian, Rajeev | ABP : predictor based management of DRAM row buffers | DRAM accesses are costly, especially in multicore systems. Future CMPs will run a mixed load of workloads/threads. Destructive interference at memory controller, spatio-temporal locality lost! DRAM row-buffer hits are least expensive, row-conflicts are most. Randomized memory access patterns re... | 2010-10-06 | |
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Hawkes, Kristen | Affluent hunters? Some comments in light of the Alyawara case | Our recent analysis (O'Connell and Hawkes in press) of plant food collecting among the Alyawara, a central Australian hunting group, shows that the cost of subsistence is sometimes quite high, far higher than the current conven. tional wisdom regarding hunters would suggest. We infer from available ... | 1981-01-01 | |
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Hawkes, Kristen | Age-related decline in ovarian follicle stocks differ between chimpanzee (Pan troglodytes) and humans | Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (Pan troglodytes) showed follicle stock decline at the same ... | 2015-01-01 | |
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Hall, Eric S. | Aiding clinicians through summarization of perinatal data | Exploratory analysis has focused on developing summarized views of monitor-captured perinatal data to support adherence to established clinical protocols. In addition to facilitating rapid access to significant clinical trends and reducing subjective interpretation of monitor-captured data, combini... | Perinatal data; Perinatal care; Trapeze Interactive Poster | 2009-09-23 |
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Yanowitz, Frank G. | Alan E. Lindsay ECG Learning Center in Cyberspace | An interactive ECG tutorial representing an introduction to clinical electrocardiography. | Electrocardiography | 1996-09-01 |
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Gerig, Guido | Asymmetrical ventricular enlargement in Parkinsons Disease | Background-A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson's disease (PD). The current study explored these associations further. Methods-Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healt... | Structural magnetic resonance imaging; Semi-automatic segmentation; Lateral ventricular volume; Motor asymmetry; Parkinson's disease | 2007-01-01 |
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Gerig, Guido | Automatic and robust computation of 3D medial models incorporating object variability | Abstract. This paper presents a novel processing scheme for the automatic and robust computation of a medial shape model which represents an object population with shape variability. The sensitivity of medial descriptions to object variations and small boundary perturbations are fundamental problems... | 2003-01-01 | |
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DuVall, Scott L. | Automatic, near real-time reporting of communicable diseases via web syndication | Real-time, automatic surveillance of reportable diseases remains an obstacle in Public Health. Reports are generated manually by healthcare provided and sent to local or state public health offices. Web syndication is the way to publish and transmit information to subscribed users. This is typicall... | Web syndication; Electronic reporting; Real-time reporting; Trapeze Interactive Poster | 2009-09-23 |
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Gerig, Guido | Brain lesion segmentation through physical model estimation | Segmentations of brain lesions from Magnetic Resonance (MR) images is crucial for quantitative analysis of lesion populations in neuroimaging of neurological disorders. We propose a new method for segmenting lesions in brain MRI by inferring the underlying physical models for pathology. We use the r... | Magnetic resonance (MR) images; Neurological disorders; Diffusion tensor imaging (DTI). | 2008-01-01 |
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Hawkes, Kristen | Brief communication: adrenal androgens and aging: female chimpanzees (Pan troglodytes) compared with women | Ovarian cycling continues to similar ages in women and chimpanzees yet our nearest living cousins become decrepit during their fertile years and rarely outlive them. Given the importance of estrogen in maintaining physiological systems aside from fertility, similar ovarian aging in humans and chimpa... | Dehydroepiandrosterone sulfate; Senescence; Aging rates; Human longevity | 2013-01-01 |
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Arlitsch, Kenning | Collaboration and partnerships: opportunities abound | PowerPoint presentation describing some of the digital collection building partnerships of the University of Utah. Major covered projects include the Utah Digital Newspapers Program, Mountain West Digital Library, Western Waters Digital Library, and the Utah Artists Project, among others. | Digital collections; Electronic libraries; Cooperative collection building | 2006-01-22 |
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Gerig, Guido | Diffusion imaging quality control via entropy of principal direction distribution | Diffusion MR imaging has received increasing attention in the neuroimaging community, as it yields new insights into the microstructural organization of white matter that are not available with conventional MRI techniques. While the technology has enormous potential, diffusion MRI suffers from a uni... | Diffusion magnetic resonance imaging; Diffusion tensor imaging; Quality assessment; Entropy | 2013-01-01 |
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Frey, Lewis J. | Enhancing caBIG™ workflow for multi-tier distribution | Introduction caBIG™ Integration caBIG™ provides a GRID based application environment with data abstraction and vocabulary services, workflow management and a security framework. Sensor Abstraction Interface It is proposed to provide a sensor abstraction interface, using caDSR, enabling caBIG... | caBIG; Sensor abstraction interface; Multi-tier distribution; Trapeze Interactive Poster | 2009 |
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Hawkes, Kristen | Evaluating grandmother effects | Women who have outlived child-bearing have long been described as post-reproductive. But contributions they make to the survival or fertility of their descendants enhance the reproduction of their genes. Consequently natural selection affects this characteristic stage of human life history. Grandmot... | Human life history; Historical demography; Human longevity | 2009-01-01 |
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Gerig, Guido | Evaluation of brain MRI alignment with the Robust Hausdorff Distance Measures | We present a novel automated method for assessment of image alignment, applied to non-rigid registration of brain Magnetic Resonance Imaging data (MRI) for image-guided neurosurgery. We propose a number of robust modifications to the Hausdorff distance (HD) metric, and apply it to the edges recovere... | Magnetic resonance imaging (MRI) | 2008-01-01 |
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Gerig, Guido | Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis | Diffusion tensor imaging (DTI) has become the major modality to study properties of white matter and the geometry of fiber tracts of the human brain. Clinical studies mostly focus on regional statistics of fractional anisotropy (FA) and mean diffusivity (MD) derived from tensors. Existing analysis t... | Diffusion tensor interpolation, Diffusion tensor statistics, DTI analysis, Fiber tract modeling | 2006-01-01 |
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Gerig, Guido | Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months | Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy tha... | Joint attention; DTI; Amygdala; Uncinate fasciculus; Infancy; Development | 2013-01-01 |
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Arlitsch, Kenning | Future leaders of research libraries: what are they thinking? | Summarizes the initial findings of survey research conducted with 175 future library leaders. Respondents were asked whether they are satisfied with their organizational culture and management, whether organizational culture limits thier effectiveness, and whether respondents are consideringleaving... | Future leaders | 2009-04-06 |
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Hawkes, Kristen | The grandmother effect | Why do women live long past the age of child-bearing? Contrary to common wisdom, this phenomenon is not new, and is not due to support for the elderly. Rather, grannies have a lot to offer their grandchildren. | 2004-01-01 | |
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Hawkes, Kristen | Grandmother effects, heterogeneity, and the evolution of human aging: guidance from human-chimpanzee comparisons | In the first paper to present formal theory explaining that senescence is a consequence of natural selection, W. D. Hamilton concluded that human postmenopausal longevity results from the contributions of ancestral grandmothers to the reproduction of their relatives. A grandmother hypothesis, subseq... | Evolution of senescence; Heterogeneity of frailty; Human life history; Menopause; Human aging | 2010-01-01 |
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Hawkes, Kristen | Grandmothers and the evolution of human longevity: a review of findings and future directions | Women and female great apes both continue giving birth into their forties, but not beyond. However humans live much longer than other apes do.[1] Even in hunting and gathering societies, where the mortality rate is high, adult life spans average twice those of chimpanzees, which become decrepit duri... | Life history evolution; Senescence; Cooperative child rearing; Infant psychology; Male-male competition | 2013-01-01 |
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Gerig, Guido | Group analysis of DTI fiber tract statistics with application to neurodevelopment | Diffusion tensor imaging (DTI) provides a unique source of information about the underlying tissue structure of brain white matter in vivo including both the geometry of major fiber bundles as well as quantitative information about tissue properties represented by derived tensor measures. This paper... | Diffusion tensor imaging; Registration; Tract modeling; Neurodevelopment; Statistical modeling | 2009-01-01 |
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Dennis, Sharon E.; Uijtdehaage, Sebastian; Candler, C. | Health Education Assets Library (HEAL) | The Health Education Assets Library (HEAL) is a digital library that provides freely accessible digital teaching resources of the highest quality that meet the needs of today's health sciences educators and learners. | HEAL; Health Education Assets Library | 2000 |
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Hawkes, Kristen | Human actuarial aging increases faster when background death rates are lower: a consequence of differential heterogeneity? | Many analyses of human populations have found that age-specific mortality rates increase faster across most of adulthood when overall mortality levels decline. This contradicts the relationship often expected from Williams' classic hypothesis about the effects of natural selection on the evolution o... | Frailty; Gompertz; Mortality rate doubling times; Ricklefs' omega; Strehler-Mildvan correlations; Weibull | 2011-01-01 |
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Gerig, Guido | Hypothesis testing with nonlinear shape models | We present a method for two-sample hypothesis testing for statistical shape analysis using nonlinear shape models. Our approach uses a true multivariate permutation test that is invariant to the scale of different model parameters and that explicitly accounts for the dependencies between variables. ... | 2005-01-01 | |
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Hawkes, Kristen | Increased longevity evolves from grandmothering | Postmenopausal longevity may have evolved in our lineage when ancestral grandmothers subsidized their daughters' fertility by provisioning grandchildren, but the verbal hypothesis has lacked mathematical support until now. Here, we present a formal simulation in which life spans similar to those of ... | Human evolution; Life history; Sexual conflict | 2012-01-01 |
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Hawkes, Kristen | Kin selection and culture | This paper argues that while the discriminations organizing human action are cultural, and kinship in anthropology is not equivalent to genetic relatedness, the theory of kin selection developed in evolutionary biology can tell us a great deal about human social organization. Data on garden assistan... | 1983-01-01 | |
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Hawkes, Kristen | Mortality and fertility rates in humans and chimpanzees: how within-species variation complicates cross-species comparisons | A grandmother hypothesis may explain why humans evolved greater longevity while continuing to end female fertility at about the same age as do the other great apes. With that grandmother hypothesis in mind, we sought to compare age-specific mortality and fertility rates between humans and chimpanzee... | 2009-01-01 | |
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Gerig, Guido | Network inefficiencies in autism spectrum disorder at 24 months | Autism spectrum disorder (ASD) is a developmental disorder defined by behavioral symptoms that emerge during the first years of life. Associated with these symptoms are differences in the structure of a wide array of brain regions, and in the connectivity between these regions. However, the use of c... | 2014-01-01 | |
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North American Neuro-Ophthalmology Society (NANOS) | Neuro-ophthalmology virtual education library (NOVEL) | An extensive, accessible collection of high quality digital materials to cover all of neuro-ophthalmology for use by educators and students world wide. | Neuro-Ophthalmology; NOVEL; Neuro-Ophthalmology Virtual Education Library | 2005-08-11 |
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Gerig, Guido | Neuroimaging of structural pathology and connectomics in traumatic brain injury: toward personalized outcome prediction | Recent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functionalmagnetic resonance imaging (MRI and fMRI, respectively) as well as diffusion tensor imaging (DTI) has excellent potential to identify novel biomark... | Trauma; Neuroimaging; MRI/fMRI; Diffusion tensor; Outcome measures | 2012-01-01 |
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Gerig, Guido | Object models in multiscale intrinsic coordinates via m-reps | Object descriptions used for 3D segmentation by deformable models and for statistical characterization of 3D object classes benefit from having intrinsic correspondences over deformation of the objects or multiple instances in the same object class. These correspondences apply over a variety of spat... | 2003-01-01 | |
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Hawkes, Kristen | Ovarian follicle loss in humans and mice: lessons from statistical model comparison | Menopause is triggered by the number of ovarian follicles falling below a threshold number and is irreversible because oogonial stem cells disappear after birth. Since it is the result of programmed disappearance of a limited store of follicles, menopause can be predicted using mathematical models b... | Age; Follice; Mathematical; Model; Menopause; Ovary | 2010-01-01 |
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Gerig, Guido | Particle based shape regression of open surfaces with applications to developmental neuroimaging | Shape regression promises to be an important tool to study the relationship between anatomy and underlying clinical or biological parameters, such as age. In this paper we propose a new method to building shape models that incorporates regression analysis in the process of optimizing correspondences... | 2009-01-01 | |
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Gerig, Guido | Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2 | Background-Enlargement of the lateral ventricles is thought to originate from abnormal prenatal brain development and is associated with neurodevelopmental disorders. Fetal isolated mild ventriculomegaly (MVM) is associated with enlargement of lateral ventricle volumes in the neonatal period and dev... | Magnetic resonance imaging; Ultrasound; Gray matter; White matter; Cognitive development | 2012-01-01 |
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Gerig, Guido | Probabilistic fiber tracking using particle filtering | This paper presents a novel and fast probabilistic method for white matter fiber tracking from diffusion weighted MRI (DWI). We formulate fiber tracking on a nonlinear state space model which is able to capture both smoothness regularity of fibers and uncertainties of the local fiber orientations du... | 2007-01-01 | |
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Gerig, Guido | Probabilistic white matter fiber tracking using, particle filtering and von mises-fisher sampling | Standard particle filtering technique have previously been applied to the problem of fiber tracking by Brun et al. (2002) and Bjornemo et al. (2002). However, these previous attempts have not utilised the full power of the technique, and as a result the fiber paths were tracked in a goal directed wa... | Diffusion tensor MRI; Tractography; Probabilistic fiber tracking; Particle filtering; von Mises-Fisher sampling | 2009-01-01 |
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Gerig, Guido | Quantification of measurement error in DTI: theoretical predictions and validation | The presence of Rician noise in magnetic resonance imaging (MRI) introduces systematic errors in diffusion tensor imaging (DTI) measurements. This paper evaluates gradient direction schemes and tensor estimation routines to determine how to achieve the maximum accuracy and precision of tensor derive... | 2007-01-01 | |
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Gerig, Guido | Quantitative tract-based white matter development from birth to age 2 years | Few large-scale studies have been done to characterize the normal human brain white matter growth in the first years of life. We investigated white matter maturation patterns in major fiber pathways in a large cohort of healthy young children from birth to age two using diffusion parameters fraction... | White matter maturation; Axonal myelination; Early brain development; Diffusion properties; DTI atlas; Fiber tracking; Functional regression analysis | 2012-01-01 |
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Gerig, Guido | Reduced interhemispheric connectivity in schizophrenia- tractography based segmentation of the corpus callosum | Background-A reduction in interhemispheric connectivity is thought to contribute to the etiology of schizophrenia. Diffusion Tensor Imaging (DTI) measures the diffusion of water and can be used to describe the integrity of the corpus callosum white matter tracts, thereby providing information concer... | 2008-01-01 | |
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Gerig, Guido | Simulation of brain tumors in MR images for evaluation of segmentation efficacy. | Obtaining validation data and comparison metrics for segmentation of magnetic resonance images (MRI) are difficult tasks due to the lack of reliable ground truth. This problem is even more evident for images presenting pathology, which can both alter tissue appearance through infiltration and cause ... | Brain MRI; Segmentation validation; Tumor simulation; Simulation of tumor infiltration; Diffusion tensor imaging; Ground truth; Gold standard | 2009-01-01 |
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Gerig, Guido | Spatiotemporal atlas estimation for developmental delay detection in longitudinal datasets | We propose a new methodology to analyze the anatomical variability of a set of longitudinal data (population scanned at several ages). This method accounts not only for the usual 3D anatomical variability (geometry of structures), but also for possible changes in the dynamics of evolution of the str... | 2009-01-01 | |
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Gerig, Guido | Unbiased atlas formation via large deformations metric mapping | The construction of population atlases is a key issue in medical image analysis, and particularly in brain mapping. Large sets of images are mapped into a common coordinate system to study intrapopulation variability and inter-population differences, to provide voxelwise mapping of functional sites,... | Computational anatomy; Brain atlases; Image metric space | 2005-01-01 |
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Gerig, Guido | User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability | Active contour segmentation and its robust implementation using level set methods are well-established theoretical approaches that have been studied thoroughly in the image analysis literature. Despite the existence of these powerful segmentation methods, the needs of clinical research continue to b... | Computational anatomy; Image segmentation; Caudate nucleus; 3D active contour models; Open source software; Validation; Anatomical objects | 2006-01-01 |
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Gerton, Jordan | Using a sharp metal tip to control the polarization and direction of emission from a quantum dot | Optical antennas can be used to manipulate the direction and polarization of radiation from an emitter. Usually, these metallic nanostructures utilize localized plasmon resonances to generate highly directional and strongly polarized emission, which is determined predominantly by the antenna geometr... | 2014-01-01 | |
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Gerig, Guido | Vessel tortuosity and brain tumor malignancy: a blinded study | Rationale-Malignancy provokes regional changes to vessel shape. Characteristic vessel tortuosity abnormalities appear early during tumor development, affect initially healthy vessels, spread beyond the confines of tumor margins, and do not simply mirror tissue perfusion. The ability to detect and qu... | Computer; Cancer; Blood vessels; Tortuosity; MRA; Brain tumor | 2005-01-01 |
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