Creator | Title | Description | Subject | Date | ||
---|---|---|---|---|---|---|
1 | Bastiani, Michael; Bandyopadhyay, Pradip K.; Olivera, Baldomero M.; Golic, Kent G. | Targeted mutagenesis by homologous recombination in D. melanogaster | We used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, including the homolog of the p53 tumor suppressor. Transgenic expression of the FLP site-specific recombinase and the I-SceI endonuclease generates extrachromosomal linear DNA molecules in vivo. | Mutations; Drosophila; Gene targeting | 2002 |