Filters: Collection: "ir_uspace" Subject: "Mice"
1 - 25 of 4
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
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Capecchi, Mario R. | Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system | Mammalian TBP consists of a 180 amino acid core that is common to all eukaryotes, fused to a vertebrate-specific N-terminal domain. We generated mice having a modified tbp allele, tbp(DeltaN), that produces a version of TBP lacking 111 of the 135 vertebrate-specific amino acids. Most tbp(DeltaN/Delt... | Alleles; Animals, Genetically Modified; Binding Sites; Embryonic and Fetal Development; Evolution, Molecular; Female; Fetus; Immune Tolerance; Male; Mice; Mutation; ATA-Box Binding Protein | 2002-07-12 |
| 2 |
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Thomas, Kirk R.; Capecchi, Mario R. | Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. | Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heter... | Animals; Cell Line; Drug Resistance, Microbial; Fibroblasts; Mice; Models, Genetic; Neomycin; Plasmids | 1986-11-06 |
| 3 |
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Thomas, Kirk R.; Capecchi, Mario R. | Maintenance of functional equivalence during paralogous Hox gene evolution. | Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene comp... | Alleles; Animals; Cervical Vertebrae; Embryo; Genetic Complementation Test; Homeodomain Proteins; Homozygote; Mice | 2000-02-10 |
| 4 |
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Capecchi, Mario R. | Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. | We examined the fate of DNA microinjected into nuclei of cultured mammalian cells. The sequence composition and the physical form of the vector carrying the selectable gene affected the efficiency of DNA-mediated transformation. Introduction of sequences near the simian virus 40 origin of DNA replic... | Base Sequence; Cell Line; Genes, Viral; Genetic Vectors; Mice; Microinjections | 1982-11 |
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