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1 Camp, Nicola J.Genome-wide linkage analysis for aggressive prostate cancer in Utah high risk pedigreesResearch has consistently shown that genetics plays a critical role in prostate cancer (CaP) development, but the identification of CaP genes has proven to be very difficult. Hereditary prostate cancer is a complex disease involving numerous genes and variable phenotypic expression. This heterogene...Linkage analysis; Aggressive prostate cancer; CaP genes; ICPCG; Utah; Trapeze Interactive Poster2009
2 Camp, Nicola J.SumLINK statistic for linkage analysis: application to the ICPCG pooled linkage resourceWe propose a novel, genome-wide, linkagebased statistic, "sumLINK," for identification of disease susceptibility loci. Our approach focuses primarily on "linked" pedigrees (those with pedigree-specific LOD ? 0.588; equivalent to unadjusted p ? 0.05) to identify regions of extreme consistency across ...SumLINK; Linkage analysis; ICPCG; Disease susceptibility loci; Trapeze Interactive Poster2009
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