Creator | Title | Description | Subject | Date | ||
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1 |
![]() | Capecchi, Mario R. | Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. | Gene targeting in mouse embryo-derived stem cells has been used to generate mice with a disruption in the homeobox gene Hox-1.6. Mice heterozygous at the Hox-1.6 locus appear normal, whereas Hox-1.6-/Hox-1.6- mice die at or shortly after birth. These homozygotes exhibit profound defects in the forma... | Chromosome Mapping; Genetic Vectors; Mice, Inbred C57BL | 2002-06-27 |
2 |
![]() | O'Rourke, Dennis H. | Refutation of the general single locus model for the etiology of schizophrenia | All published studies on the familial incidence of schizophrenia appropriate for testing the applicability of the general single-locus two-allele model are examined under the assumption of a unitary etiology for all schizophrenia. We show that the single major locus model is inadequate to predict th... | Genetics; Diseases in Twins; Chromosome Mapping | 1982 |