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| Creator | Title | Description | Subject | Date | ||
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Couldwell, William T. | Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen | PREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from... | Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma | 1993 |
| 2 |
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Couldwell, William T. | Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomas | The monoclonal antibody Ki-67 recognizes a nuclear antigen expressed in the G1, S, G2, and M phase of the cell cycle and has been used extensively as an indicator of cellular proliferation in malignant gliomas, both in the laboratory and clinically. Recently, protein kinase C (PKC) inhibitors have b... | Brain neoplasm; Chemotherapy; Glioma; Monoclonal antibody; Ki-67; Protein kinase C; Tamoxifen | 1995 |
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