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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
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Couldwell, William T. | Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system | The protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administrat... | Protein kinase C; Phorbol ester; Cell proliferation; Tumor cell growth; Astrocyte; Glioma; Immunohistochemistry | 1990 |
| 2 |
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Couldwell, William T. | Malignant glioma-derived soluble factors regulate proliferation of normal adult human astrocytes | Malignant gliomas are characteristically surrounded by marked gliosis. To assess whether glioma-derived products contribute to the proliferation of astrocytes, a feature of the gliosis response, we evaluated the influence of culture supernatants from malignant human glioma lines and tumor cyst fluid... | Astrocyte; Glioma; Gliosis; Proliferation; Soluble factors | 1992 |
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