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1 Enquist, AnnekeDiscovery of platinum (II) and azulene derivative cocrystals with fluorinated cyanoaromaticsPentacyano-trifluoromethyl benzene was synthesized using a novel technique. Before isolation, it was noted that plate like crystals had formed leading to study regarding the ability of acetic acid to co-crystallize with pentacyanotrifluoromethyl benzene. The crystal structure of acetic acid with pen...2024
2 Kendell, IsaacImmunomodulation improves cancer cell clearance by T cells during multi-antigent T cell hybridizer therapyTreatment of hematopoietic malignancies is challenging due to systemic side effects of current treatments and the possibility of relapse. Multi-antigen T cell hybridizer (MATCH) therapy is a novel treatment system composed of antibody fragments conjugated with morpholino oligonucleotides, which hybr...2024
3 Martinez, TravisInvestigative work in antibiotic treatment of biofilms using a new reactor modelBiofilms are notoriously tolerant to antibiotics and a growing problem in modern healthcare, yet the inaccessibility of biofilm reactors hinders research in many instances. Existing biofilm reactors remain costly, time-consuming, and dependent on difficult-tomanage resources. To address this issue, ...2024
4 Hansen, MasonInterferon gamma inducible nampt and its role in resisting cancer cell growthThe tumor microenvironment (TME) is very complex and important due to its ability to influence the response of therapies on tumors. Immune cells infiltrate the TME and secrete inflammatory cytokines, such as interferon-gamma (IFNg), which help activate the immune system. This activation leads to an ...2023
5 Larson, BrookeChacterization of signaling to the degradative pathways of the cellProtein degradation in cells is a complex network of pathways that are distinct from each other but highly interconnected. Understanding how proteins are degraded in cells is important for understanding and developing treatments for diseases such as lysosomal storage diseases and neurodegenerative d...2023
6 Som, SaritaVirus-like weapons used for competition in wild plant populationsPlant diseases caused by bacterial pathogens pose significant economic challenges globally, necessitating the exploration of alternative methods for controlling bacterial infections in plants. Tailocins, virus-like weapons produced by bacteria, have emerged as potent antibacterial agents and hold po...2023
7 Gerton, MarinaEffects of carbon sources on secondary metabolite production by teredinibacter turneraeShipworms are wood-digesting marine bivalves that rely upon symbiotic bacteria for cellulose digestion. The symbiotic bacteria, which grow intracellularly in shipworm gill tissue, produce cellulases that are then transported to the shipworm's cecum. It has also been hypothesized that the bacteria pr...2023
8 Halberg, CharlesOn causality in machine learningAlthough the studies of causal inference and machine learning arose independently, there are emerging intersections which are proving fruitful for both fields. One of the major modern challenges in AI is to develop robust, generalizable models which can perform across a number of different tasks wit...2022
9 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
10 Sperber, Alexander M.A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cellsHeart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I...2022
11 Nilson, Jens C.An examination of the bioethical and legal dilemmas surrounding genetic editing through narrative and story tellingExamining complex topics and issues through narrative and storytelling is a staple of the fiction genre. By presenting abstract problems and ethical dilemmas in a relatable context, and giving examples attached to real characters, the reader becomes emotionally and mentally invested in the issues fa...2022
12 Meaux, Scott AlanBorders of immunity redefined under the scope of scaleBorders. A line in the sand as it were, a place with a definite beginning and a hazy ending. Whether respected or disregarded, an entity that most simply can't ignore. The choice to see them as helpful or to ensure harm, divisiveness washes away all connotation. Often defined in the classroom as an ...2022
13 Vandamme, Elise-MarieThe role of dehydroepiandrosterone in the pathophysiology of Tourette syndrome: preclinical studiesTourette syndrome (TS) is a neurodevelopmental condition with a marked male predominance (M: F= 3:1), characterized by multiple motor and one or more vocal tics for more than one year and beginning before the age of 18 (Robertson, 2019). Our understanding of TS pathophysiology remains limited; as a ...2022
14 Ward, Bridget E.Functionalizing a hemagglutinin epitope tag for induced mitochondrial protein degradation in saccharomyces cerevisiaeMitochondria are organelles known for their role in many critical cellular processes including the production of metabolic energy in eukaryotic cells. In order to produce this energy, mitochondria continually transport metabolites across the impermeable mitochondrial inner membrane. The transport of...2022
15 Pace, Eliza JaneHigh School curriculum on social media and mental wellbeing: combating the negative effects through education and applicationOver the past ten years, there has been a significant rise of depression and suicide rates in adolescents. These rates coincide almost exactly with the rise in smartphone use and the development of social media. Evidence of multiple studies over the last twenty years suggests that social media plays...2021
16 Kiel, DrewHow branding influences our willingness to pay for necessity productsThough marketing has existed in one manner or another for the duration of human history, the field has only seen strong development since the beginning of the 20th century. Marketing is now an inescapable part of everyday life and companies across every industry advertise of to us as potential custo...2021
17 Temme, JackA closer look at aberrant muscle functionWhen a skeletal muscle is inhibited from operating at its full function it is called an aberrant muscle. Such inhibition tends to occur after joint trauma in order to protect the injured area from further aggravation. However, inhibition can linger after the injury is healed, which negatively impact...2021
18 Amaechi, AyanaUnderstanding sex differences in early predictors of pathological aggression with a mouse modelAntisocial behavior (ASB) is characterized by aggression, violence, drug use, thrillseeking behavior, and delinquent behavior. While childhood and adolescent maltreatment contribute to the ontogeny of this condition, converging evidence suggests that genetic factors play an equally important role. T...MAOA; pathological aggression; sex differences; stress; early development; animal models2021
19 Cowley, JacobOptimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynesIn order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the...2021
20 Schlegel, Isabelle B.Peptide-fab conjugates to improve treatment of neovascular age-related macular degenerationAge-Related Macular Degeneration (AMD), a chronic disease of the eye and leading cause of blindness in Americans over 50, is often treated with agents that inhibit Vascular Endothelial Growth Factor (VEGF). Ranibizumab is an anti-VEGF antibody fragment (Fab) effective at treating over 90% of AMD pat...2021
21 Gates, AbigailHealth Care in the United States: Disparities and Distrust in the Black CommunityDuring the time of slavery, Black and African Americans were mistreated and abused as research subjects in medical studies. This mistreatment continued into the 20th century with the Tuskegee Syphilis study and continues today in many doctor's offices throughout America. This paper begins by looking...2020
22 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
23 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
24 Gonzalez, Marcos DavidAn Analysis of the Court of Arbitration system: Status & Power Through the Lens of LaugtherLaughter is a nonverbal communication that demonstrates status and power across contexts such as hospital wards, fraternities, and even the United States Supreme Court. While it may be humorous in nature, the implications of laughter as a symbol that gathers perceived status, a mediator of social hi...2020
25 Dean, EmmaThe Effects of maternal resilience on newborn neurobehavioral outcomesThere is growing evidence that exposure to prenatal maternal stress may adversely affect fetal neurodevelopment by altering the fetal environment. In this study, we investigated whether maternal resilience can act as a moderator of the negative effects of maternal stress on newborn neurobehavioral o...2020
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