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1 Som, SaritaVirus-like weapons used for competition in wild plant populationsPlant diseases caused by bacterial pathogens pose significant economic challenges globally, necessitating the exploration of alternative methods for controlling bacterial infections in plants. Tailocins, virus-like weapons produced by bacteria, have emerged as potent antibacterial agents and hold po...2023
2 Larson, BrookeChacterization of signaling to the degradative pathways of the cellProtein degradation in cells is a complex network of pathways that are distinct from each other but highly interconnected. Understanding how proteins are degraded in cells is important for understanding and developing treatments for diseases such as lysosomal storage diseases and neurodegenerative d...2023
3 Hansen, MasonIntereferon gamma inducible nampt and its role in resisting cancer cell growth2023
4 Halberg, CharlesOn causality in machine learningAlthough the studies of causal inference and machine learning arose independently, there are emerging intersections which are proving fruitful for both fields. One of the major modern challenges in AI is to develop robust, generalizable models which can perform across a number of different tasks wit...2022
5 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
6 Sperber, Alexander M.A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cellsHeart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I...2022
7 Nilson, Jens C.An examination of the bioethical and legal dilemmas surrounding genetic editing through narrative and story tellingExamining complex topics and issues through narrative and storytelling is a staple of the fiction genre. By presenting abstract problems and ethical dilemmas in a relatable context, and giving examples attached to real characters, the reader becomes emotionally and mentally invested in the issues fa...2022
8 Ward, Bridget E.Functionalizing a hemagglutinin epitope tag for induced mitochondrial protein degradation in saccharomyces cerevisiaeMitochondria are organelles known for their role in many critical cellular processes including the production of metabolic energy in eukaryotic cells. In order to produce this energy, mitochondria continually transport metabolites across the impermeable mitochondrial inner membrane. The transport of...2022
9 Pace, Eliza JaneHigh School curriculum on social media and mental wellbeing: combating the negative effects through education and applicationOver the past ten years, there has been a significant rise of depression and suicide rates in adolescents. These rates coincide almost exactly with the rise in smartphone use and the development of social media. Evidence of multiple studies over the last twenty years suggests that social media plays...2021
10 Schlegel, Isabelle B.Peptide-fab conjugates to improve treatment of neovascular age-related macular degenerationAge-Related Macular Degeneration (AMD), a chronic disease of the eye and leading cause of blindness in Americans over 50, is often treated with agents that inhibit Vascular Endothelial Growth Factor (VEGF). Ranibizumab is an anti-VEGF antibody fragment (Fab) effective at treating over 90% of AMD pat...2021
11 Amaechi, AyanaUnderstanding sex differences in early predictors of pathological aggression with a mouse modelAntisocial behavior (ASB) is characterized by aggression, violence, drug use, thrillseeking behavior, and delinquent behavior. While childhood and adolescent maltreatment contribute to the ontogeny of this condition, converging evidence suggests that genetic factors play an equally important role. T...MAOA; pathological aggression; sex differences; stress; early development; animal models2021
12 Cowley, JacobOptimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynesIn order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the...2021
13 Kiel, DrewHow branding influences our willingness to pay for necessity products2021
14 Gates, AbigailHealth Care in the United States: Disparities and Distrust in the Black CommunityDuring the time of slavery, Black and African Americans were mistreated and abused as research subjects in medical studies. This mistreatment continued into the 20th century with the Tuskegee Syphilis study and continues today in many doctor's offices throughout America. This paper begins by looking...2020
15 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
16 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
17 Gonzalez, Marcos DavidAn Analysis of the Court of Arbitration system: Status & Power Through the Lens of LaugtherLaughter is a nonverbal communication that demonstrates status and power across contexts such as hospital wards, fraternities, and even the United States Supreme Court. While it may be humorous in nature, the implications of laughter as a symbol that gathers perceived status, a mediator of social hi...2020
18 Dean, EmmaThe Effects of maternal resilience on newborn neurobehavioral outcomesThere is growing evidence that exposure to prenatal maternal stress may adversely affect fetal neurodevelopment by altering the fetal environment. In this study, we investigated whether maternal resilience can act as a moderator of the negative effects of maternal stress on newborn neurobehavioral o...2020
19 Ballif, MicahDrugs and Pregnancy: Clinical Management with a Cystic Fibrosis FocusDespite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise...2019
20 Lotz, Mahalia G.Victim/Survivor Notifications on Utah Sexual Assault Kit Re-Traumatization & Engagement in the Criminal Legal SystemThis paper provides context for the creation, discovery, and aftermath of the multitude of unsubmitted sexual assault kits. It continues by describing the efforts of the Utah Sexual Assault Kit Initiative (SAKI) group to address the issues created by the unsubmitted kits. This paper specifically exa...2019
21 Kodele, ChristianMultivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma CellsNon-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon...2018
22 Tarboton, PaisleyCharacterization of Apoptosis and Inhibitory Neurons in Cortical Organoids Generated from Human Induced Pluripotent Stem Cells.Modeling human brain diseases in a laboratory setting is critical to understanding the underlying pathology and developing new treatments for patients. Organoids are 3D tissue cultures that provide a promising way to model human brain development in vitro and have been used previously to gain novel ...2018
23 Leibold, Katherine I.The Electability of Atheists in the United StatesAtheists are severely underrepresented in United States public offices. This underrepresentation is obvious when evaluating the religious affiliation of our elected officials in Congress in contrast to the religious affiliations of the general public. The underrepresentation of atheists in Congress ...2018
24 Sedley, AndrewEgocentric Navigation in a Morris Water Maze for Testing Memory Formation in MiceMouse models are crucial to understanding not only sensory and cognitive neurological processes, but also diseases, disabilities, and responses to pharmacological or surgical treatments. Behavioral tests are essential assets in the description of these models. The Morris Water Maze is a common behav...2018
25 Davis, Kacey A.Expression and Purification of Augertoxins: Searching for Novel Protein Folds in Venomous Marine SnailsThis study describes a method for bacterial expression and purification of previously uncharacterized proteins. The proteins chosen for this study come from auger snail toxins, which have evolved to help the snail hunt and kill their prey. Evolutionary pressure between predator and prey selects for ...2018
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