|
|
Creator | Title | Description | Subject | Date |
1 |
|
Koblanski, Kasper | Liver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilization | Insulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin... | | 2022 |
2 |
|
Yang, Kevin | The Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in Mice | Earlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ... | | |
3 |
|
Walker, Kortnie | Understanding and treating diabetic retinopathy | Diabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre... | Diabetic retinopathy | 2015-05 |
4 |
|
Russo, Jennifer | Do reproductive-age women increase their physical activity levels during the first four weeks of the diabetes prevention program? | Purpose: The purpose of this thesis was to determine if reproductive-age women enrolled in the Diabetes Prevention Program (DPP) increased their physical activity levels in the first four weeks of the lifestyle change program and to examine the relationship between physical activity levels and lifes... | | 2021 |
5 |
|
Rashid, Inakhshmi | Communication between young adults and family members with type 2 diabetes | With a staggering 537 million adults living with type 2 diabetes (T2D) as of 2021, T2D has become one of the most prevalent chronic conditions in the world. Lowering this prevalence is possible as T2D is preventable through healthy lifestyle habits, even amongst people with an increased risk due to ... | | 2023 |
6 |
|
Johnson, KariAnne Rencher | Identification of PASK substrates and/or interacting proteins | PAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live... | Biology | 2012-05 |
7 |
|
Astin, Holly M. | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | | | 2016 |
8 |
|
Ruan, Ting | Endogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2A | Cardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati... | Ceramides - Physiological effect; Diabetic angiopathies | 2014 |
9 |
|
Thompson, Lauren | SptlC2 Deletion in Endothelial Cells: Implications for Arterial Function | Using pharmacological and genetic approaches to inhibit whole-body ceramide biosynthesis, our laboratory showed that this sphingolipid contributes importantly to hypertension and vascular dysfunction associated with diet-induced obesity in mice. Here we tested the hypothesis that inducible, endothel... | | 2020 |
10 |
|
Smith, Jaclynn Kehaulani | A feasibility trial to determine the effect of mindfulness on weight-loss maintenance | PURPOSE: Over 70% of all adults in the U.S. have overweight and obesity. Weight loss is often recommended to improve overall health and risk of disease. However, weight regain following intentional weight loss is common and diminishes initial improvements. Therefore, interventions aimed at attenuati... | | 2023 |
11 |
|
Chong, Alisha | Effects of increasing sleep duration on C-Reactive protein, insulin sensitivity, and blood pressure in adults with habitual short sleep | Short sleep, cardiovascular disease, and type 2 diabetes are all highly prevalent health issues in modern society. Previous findings demonstrate that obtaining short sleep is linked to an increased risk of cardiometabolic diseases such as type 2 diabetes and heart disease. However, the mechanisms un... | | 2023 |
12 |
|
Christopher Depner | Effects of increasing sleep duration on C-Reactive protein, insulin sensitivity, and blood pressure in adults with habitual short sleep | | | 2023 |
13 |
|
Lei, Jeffrey KaChon | Increased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunction | Lifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa... | Bioengineering | 2013-04 |
14 |
|
Ballif, Micah | Drugs and Pregnancy: Clinical Management with a Cystic Fibrosis Focus | Despite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise... | | 2019 |
15 |
|
Pham, John V. | The function of the protein VCP/CDC48-associated mitochondrial stress-responsive 1 in mammals | Although mitochondrial dysfunction has been linked to many human diseases, mitochondrial interacting proteins and protein quality controls are just beginning to be understood. The objective of our study was to characterize the function of the VMS1 protein in mammals. We determined the role of Vms1 o... | Mitochondrial disorders; Mitochondrial diseases - genetics; VMS1 | 2012-05 |
16 |
|
Astin, M. Holly | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | The liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis... | Liver X receptors - Research; Zebrafish - genetics | 2016-08 |
17 |
|
Farese, Ludovica | The impact of Global Health education in American Academic Medical Center (AAMCS) | Global health has become an increasingly popular field of study among college and graduate students in the United States. A growing body of literature purports the benefits of Global Health Education (GHEs) in American Academic Medical Centers (AAMCs), including introduction to a wider spectrum of d... | | 2018 |
18 |
|
Meaux, Scott Alan | Borders of immunity redefined under the scope of scale | Borders. A line in the sand as it were, a place with a definite beginning and a hazy ending. Whether respected or disregarded, an entity that most simply can't ignore. The choice to see them as helpful or to ensure harm, divisiveness washes away all connotation. Often defined in the classroom as an ... | | 2022 |
19 |
|
Rose, Steven | Biofuel cells for self powered arsenic detection | Research in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, wi... | Fuel cells; Arsenic - Detection | 2013-05 |
20 |
|
Kasera, Shalini | Effect of IUGR and supplemental DHA on molecular mediators of hepatic lipid accumulation in the rat | Intrauterine growth restriction (IUGR) refers to failure of the fetus to achieve its genetic growth potential in utero and is commonly caused by uteroplacental insufficiency secondary to maternal hypertensive disorders. A hallmark of IUGR is a decrease in circulating docosahexaenoic acid (DHA), an �... | | 2022 |
21 |
|
McFarland, Casey | Hospital-Acquired pressure injury risk in medical intensive care unit patients with COVID-19: a retrospective cohort study | Background: Hospital acquired pressure injuries (HAPrIs), defined as injuries to the skin or underlying tissue as a result of pressure or pressure in combination with shear, occur in approximately 6% MICU patients at the University of Utah hospital. HAPrIs are associated with longer length of hospit... | | 2021 |
22 |
|
Stewart, Caden | Paternal diet modulates naturalistic foraging in mice and interacts with cacna1c genetic effects to shape decision sequences | Some of the largest challenges facing the healthcare system stem from the dual epidemics of obesity and mental disorders. Obesity can alter an organism's epigenetics, and these changes may be passed on to offspring, which in turn may alter mental health. The purpose of this study is to investigate t... | | 2022 |
23 |
|
Ramous, Caroline | Is Intact Endothelial Cell Autophagy Required for Training-Induced Vascular Adaptations? | Macroautophagy is operational during basal conditions to maintain intracellular organelle and protein quality control, but is upregulated during cellular stress (e.g., dynamic exercise) to adapt to changing nutritional and energy demands. We tested the hypothesis that intact endothelial cell (EC) au... | | 2020 |
24 |
|
Sanders, Sara | Development of a novel, coumarin-europium sensor for reactive oxidizing species | The synthetic framework has been developed for two fluorescent probes of Reactive Oxidizing Species (RoxS) based on a coumarin-europium fluorescence pair. The coumarin moiety's selectivity for hydrogen peroxide coupled with 620 nm shifted emission of the europium will make these novel sensors biolog... | Reactive Oxygen Species - analysis | 2012-05 |
25 |
|
Ellis, James H. | Refractory status epilepticus and chronic kidney disease in a large pedigree due to a variant in the mitochondrial encoded trna phenylalanine (MT-TF) gene | Mitochondrial disorders present with a wide spectrum of neurological manifestations. Clinical syndromes are described largely by phenotypic indicators. Epilepsy is a common but not universal feature. Myoclonus epilepsy with ragged red fibers (MERRF) is a common clinical syndrome that presents with e... | | 2018 |