Honors Theses Open Access
 
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51 Estrada, JohannaBCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Philadelphia cromosome-positive leukemiaCML 1s caused by a random reciprocal translocation that joins the ABL1 gene on chromosome 9, with the BCR gene on chromosome 22. The result is the formation of the oncogenic BCR-ABL1 gene. This derivative chromosome is widely known as the Philadelphia Chromosome (Ph+), and it encodes a deregulated, ...Leukemia -- Genetic aspects -- Research Leukemia -- Treatment -- Research2014-04
52 Liu, JiaIndicators of Burden in Conversations Between CaregiversWhen facing a challenge to provide sufficient resources and services to a growing elderly population, family caregivers will be required to provide the majority of care at home, leading to increased stress and burden. While this phenomenon is well-recognized in the research literature, and many atte...2018
53 Lietzke, StephanieRemoval of endotoxins from recombinant antithrombinEndotoxins (also known as lipopolysaccharides or ETs) are a pyrogenic byproduct of the breakdown of gram-negative bacterial cell-walls, such as E. coli. They cause fever and septic shock in humans, and are therefore highly regulated by the FDA and USP. ETs are a common contaminant in recombinant pr...Endotoxins - Research; Antithrombins - Therapeutic use; Sheep as laboratory animals - Research; endotoxin removal; Angiogenesis2016-04
54 Yoo, ChaekyungPurification and physical characterization of intrinsically disordered lea protein from arabidopsis thalianaFor many decades, it was assumed that protein function was dependent on the ability of polypeptides to fold into stable three-dimensional structures specified by their amino acid sequences. But since about 2000, it has become apparent that there are functional proteins, or portions of proteins, that...Intrinsically disordered proteins2014-08
55 Gills, LyraLiving while alive: a brief proposal for Puerto Piramides, Argentina, to attain Blue Zone Project Community (BZPC) statusIn 2004, Blue Zones, or places where men and women live well past 90 or 100 years of age, were discovered by Dan Buettner and his team from National Geographic. Today, there are five well known Blue Zones, as well as four Blue Zone Project Communities that can be found.Blue Zones; centenarians2021-05
56 Craner, Bethlyn "Buffy" SageA nation of inequality: The effects of inequality on health, crime and economic achievementIncome inequality is on the rise, growing rapidly since the mid 1970's in the United States of America (Weeks 2007). This study will investigate the effects an increasing gap between the affluent and impoverished has on critical factors of social welfare. A meta-assessment will be performed combinin...Income inequality - United States2012-05
57 Leonard, NicoleVitamin D deficiency in flight attendants and pilotsVitamin D is a curious molecule. While humans do get some vitamin D from their diet, most of it is synthesized in the body, so it does not fit the definition of a vitamin-a molecule that must come from the diet. Vitamin D synthesis is initiated by the UVB (290-320 nm) portion of ultraviolet radiatio...Vitamin D deficiency; Flight attendants -- Nutrition; Air pilots -- Nutrition; Ultraviolet radiation -- Physiological effect2015-04
58 Ramous, CarolineIs Intact Endothelial Cell Autophagy Required for Training-Induced Vascular Adaptations?Macroautophagy is operational during basal conditions to maintain intracellular organelle and protein quality control, but is upregulated during cellular stress (e.g., dynamic exercise) to adapt to changing nutritional and energy demands. We tested the hypothesis that intact endothelial cell (EC) au...2020
59 Lee, ZacharyUsing Drosophila to investigate p53 life-or-death decisionsThe p53 tumor suppressor is a central regulator of cellular responses to DNA damage. When DNA damage cannot be repaired most cells undergo p53-dependent cell death. Thisp55-mediated apoptosis is important to eliminate cells with damaged genomes and provides an important block to the development of c...Biology2013-05
60 Steiner, WilliamRegulation of protein complexes during hedgehog signal transductionThe Hedgehog (Hh) pathway is an evolutionarily conserved signaling pathway essential in embryonic development and tissue homeostasis. Several cancers can form as a result of Hh pathway dysfunction. The G protein-coupled receptor (GPCR) Smoothened (SMO) is activated upon binding of the secreted Hh pr...2021
61 Lewis, AlexJournaling as a central focus in the secondary classroomFor my thesis project, I have studied the role of journaling into a secondary language arts classroom. Everyone can learn about themselves through writing, and I have explored this idea further. We can learn a lot when we simply put our pens to paper and write what we already have within our minds,...Diaries - Authorship - Study and teaching (Secondary); Creative writing (Secondary education)2013-04
62 Yang, KevinThe Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in MiceEarlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ...
63 Capener, JacobG Protein-Coupled resecptor kinase 2 mediated phosphorylation for The Activation of SmoothenedThe Hedgehog (Hh) pathway is a cell signaling pathway that is involved in embryonic development and adult tissue maintenance in vertebrates. Improper functioning of this pathway can lead to developmental disorders and several forms of cancer. Despite the pathway's biological importance, the transduc...2020
64 Fink, SusanThe role of emotion regulation in understanding the link between benefit finding and adherence in adolescents with Type 1 DiabetesAdolescents with type 1 diabetes find managing their disease difficult and they often experience problems in adhering to their diabetes regimen. Adolescents who are able to find benefits from their diabetes may be able to maintain better diabetes management, in part as they are able to process and r...
65 Stephens, MasonEffect of prolonged nature exposure on mindfulness and P300 AmplitudeThis study utilized a quasi-experimental, within-subjects design to explore the effects of a 5-day nature immersion on perceived mindfulness, behavioral performance, and brain wave activity using Electroencephalography (EEG) to assess the amplitude of the P3a and P3b Event-Related Brain Potentials. ...2020
66 Groneman, AmandaEducational Programming: A Coping and Distraction Trchnique in Pediatric Hospital SettingsThe experience of hospitalization is a unique and typically difficult experience for most children. Many children's hospitals strive to provide various services to help children cope with the difficult emotions and distract them from the pain they may be feeling. In addition to Child Life Interventi...2018
67 Maruta, NeneReproductive health and Barriers to Care Among Women With DisabilitiesWomen with disabilities face many barriers when accessing healthcare. Barriers can include emotional stressors, inaccessible exam tables, and the lack of provider understanding about specific disabilities. Continued barriers to accessing reproductive healthcare for women with disabilities can impact...2020
68 Long, DanielleDiabetes risk, physical activity, and the physical environmentThe current exploratory study investigated the relationships among subjective and objective physical environment ratings, physical activity, and diabetes status. The basic question was whether diabetics were less physically active than non-diabetics and if this lack of physical activity was due to d...Psychology2014-05
69 Weaver, ShannonFree Clinic Health Education Classes: an Analysis of Efficacy, Barriers, Power Dynamics, and DisparitiesPart I- Power Dynamics Present in Health Education Classes at a Free Clinic Objective: The purpose of this paper is to analyze dynamics between patients, staff, and volunteers at a free clinic. Certain power dynamics within health care are inherent and beneficial, such as a provider prescribing medi...2017
70 de Andrade, Debora Brito"Nadie Me Entiende" [No one understand me]: impacts of cultural and language barriers on social isolation and loneliness in Spanish-speaking older adultsCultural and language barriers during the older stages of life can lead to an increased risk for social isolation and loneliness. Furthermore, Spanish-speaking adults are more likely to have poor access to care in Utah and in the rest of the United States, which decreases the likelihood of detection...2021
71 David, MariaThe Effect of Physician Altruism on Patient Health Outcomes in a Signaline GameI construct a model for interactions between patients and physicians and use the model to explore which conditions are necessary for the patient to receive a certain quality of care. The model allows the patient, upon observing an illness, to choose between treatment or no treatment options while th...2017
72 Zhu, JudyAnalysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoinOxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d...Oxidation; guanine oxidation products; 5-guanidinohydantoin; Iminoallantoin; Equilibrium relationship2015-05
73 Visser, JoshuaCharacterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongationGuanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca...DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers2016-05
74 Gilbert, HenryDevelopment of a Power over Ethernet (POE) Airu SensorPoor air quality has been linked to both health and economic concerns, and is a growing research topic in Salt Lake City. The AQ&U program at the University of Utah strives to develop a large network of low-cost air quality sensors (AirU's) to study air pollution throughout the Salt Lake valley. Man...2020
75 Warren, Bailey J.In context of consumer education: the environmental, human health, and community based externalities of confinement operations in BrazilConcentrated Animal Feeding Operations (henceforth CAFOs) are a signature feature of modern food production and consumption. This thesis will explore the various types of environmental pollution and contamination that surround CAFOs and what this means for neighboring ecosystems, human health, and t...2022
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