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26 Guynn, Isaac P. A.Confirming and quantifying ectoine production in Salinovibrio SP. eagsl in hypersaline cultureSalinivibrio sp. EAGSL was isolated from the Great Salt Lake in 2017 and has since been the focus of promising research in the field of microbial electrochemistry. Namely, S. EAGSL is an organism with both halotolerance and electroactivity, giving it a unique ability to bridge the gap between power ...2022
27 Khuu, ScottIdentifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal TransitionCancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski...2017
28 Pecchia-Bekkum, AnnikaApplications of controlled DNA assembly and disassembly in biosensing and responsive drug deliveryDeoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In...Nucleic acids - Biotechnology2013-08
29 Ward, Bridget E.Functionalizing a hemagglutinin epitope tag for induced mitochondrial protein degradation in saccharomyces cerevisiaeMitochondria are organelles known for their role in many critical cellular processes including the production of metabolic energy in eukaryotic cells. In order to produce this energy, mitochondria continually transport metabolites across the impermeable mitochondrial inner membrane. The transport of...2022
30 Reynolds, MiraGuilt and shame among military personnel and veterans who have experienced military sexual traumaObjective: Sexual trauma is more likely to result in posttraumatic stress disorder (PTSD) in women than other types of trauma. Women who have suffered any form of trauma are also more likely to experience guilt and shame than men. However, less is known about the relationship of guilt and shame wit...Sexual violence - Military; Post-traumatic stress disorder - Research - United States2016-05
31 Walker, KortnieUnderstanding and treating diabetic retinopathyDiabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre...Diabetic retinopathy2015-05
32 Keevy, JennaMore than "yes": an analysis of the elements and barriers of informed consentInformed consent is a foundational element of bioethics. It specifically tackles what it means for a patient or a participant to say "yes" to procedures and experiments. The common person may not actively realize what is entailed when they sign their name on the signature line. This, coupled with th...autonomy; informed consent; mandated choice; non-domination; presumed consent; personalized medicine; reasonable patient standard; undue inducement2024
33 Burga, Carlos AlbertoBinary superlattices of semiconductor nanocrystals : a path towards possible high-temperature superconductivityThis thesis provides a platform to experimentally test Dr. Daniel Mattis' theoretical work on the possible superconductive behavior of nanostructured intrinsic semiconductors1-2. The theoretical work hinged on the nano-scale architecture of semiconductors. Therefore, using various types of semicondu...Semiconductor nanocrystals; Superconductivity; Superlattices as materials2013-05
34 Galinat, ShelbyBipyrimidine solubility modeling for applications in NON-Aqueous redox flow batteriesEnergy storage research has undergone transformative changes in the past 50 years. The increasingly concerning threat of climate change has emphasized the need for energy storage technology to facilitate renewable energy incorporation into the grid. Without energy storage, the fluctuations of wind a...2022
35 Kim, Alexander H.DPP Signal Regulation Through O-Linked GlycosylationDorsal closure in Drosophila is an embryogenic event that involves coordinated cellular shape changes. A series of interconnected signaling cascades are utilized to accomplish this task, one of which is the Decapentaplegic (Dpp) pathway. Dpp is a member of the TFG-β family of secreted cytokines, wh...2017
36 Spurlock, Ella K.Exploration of the 2-dimensional π-d conjugated coordination polymer Cu-benzenehexathoilCoordination polymers (CPs) are a type of atomically precise material that has long been an area of study for materials chemists. Recently, research has advanced with twodimensional conjugated CPs as detailed synthetic schemes are developed to create highly atomically ordered, large-area sheets. The...2022
37 Nicolo, TeraCharacterization of mitochondria-modified electrodesIn order to develop an herbicide sensor, yeast, potato, and bovine heart mitochondria were isolated and immobilized onto Toray paper electrodes. Cyclic voltammetry showed two redox peaks at 186 ± 14 mV vs. SCE and -357 ± 24 mV vs. SCE with an E1/2 of -128 mV. Scan rate studies suggested the proces...Electrodes; Herbicides - Detection2013-05
38 Coplan, Caitlin DeniseFabrication and Application of Aluminum NanostructuresPlasmonics, the phenomenon resulting from light interactions with nanoscale structures, is an active field for nanoscale manipulation of light. By varying the metal, size, and shape, plasmonic nanostructures can be tuned to interact with a broad spectral range of light. Commonly used plasmonic mater...spectroscopies; photocatalysis; photovoltaics.2019
39 Narasipura, Eshan AmruthFull synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycinTargeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-...2021
40 Steiner, WilliamRegulation of protein complexes during hedgehog signal transductionThe Hedgehog (Hh) pathway is an evolutionarily conserved signaling pathway essential in embryonic development and tissue homeostasis. Several cancers can form as a result of Hh pathway dysfunction. The G protein-coupled receptor (GPCR) Smoothened (SMO) is activated upon binding of the secreted Hh pr...2021
41 Russell, NicoleThe Role of Introns Within Alpha Conotoxin Genes in Cone SnailsCone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi...2016
42 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
43 Zhu, JudyAnalysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoinOxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d...Oxidation; guanine oxidation products; 5-guanidinohydantoin; Iminoallantoin; Equilibrium relationship2015-05
44 Visser, JoshuaCharacterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongationGuanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca...DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers2016-05
45 Edwards, Jennifer LynnApplication of a TBHP-mediated Wacker-type oxidation to internal alkenesThe Wacker oxidation allows access to methyl ketones from terminal alkenes. This transformation is important for industrial, synthetic, and medicinal chemists, as carbonyls are present in many natural and pharmaceutical products. With the carbonyl, a wide variety of reactions become available, such ...Wacker-type oxidatioin - Research; TBHP2013-05
46 Bischoff, AmandaElucidating the Mechanism and Predicting the Selectivity of the bis(Pyridine) Silver Permanganate OxidatiinThe Movassaghi group has recently reported several total syntheses of epipolythiodiketopiperazine derivatives (ETPs), a class of natural products with potent biological activity. A crucial step in their synthesis oxidizes two to four tertiary C-H bonds to form tertiary alcohols using (bis)pyridine s...2016
47 Nash, AlexanderThe Proto-Indo-European urheimat: The Armenian hypothesisThis thesis analyzes the viability of the Armenian Hypothesis, which places the Proto-Indo-European homeland in the Armenian Highland (Gamkrelidze & Ivanov 1990, Kavoukjian 1987). Arguments supporting the hypothesis are evaluated in the light of linguistic, archeological, and genetic evidence. Afte...Proto-Indo-European langauge; Armenian Highlands2015-12
48 Franchina, Jordan AveryMeasurement of bond dissociation energies of transition metal moleculesMeasuring thermochemical and kinetic properties of chemical systems has always; been a central theme of chemistry. Knowing these properties assists us in assessing; whether or not a chemical reaction is energetically feasible, efficient, and worthwhile.; Theoretical chemistry has now developed suffi...Chemical systems; thermochemical; kinetic; modeling2018-04
49 Godfrey, RoseA porcine model for the development and testing of preoperative skin preparationsClinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu...2022
50 Arave, Rowan A.AKT1 activation promotes the development of melanoma metastasisMetastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu...Melanoma - Genetics - Research; Metastasis - Genetics - Research; Biochemistry; Genetics2015-12
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