Honors Theses Open Access
 
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26 Webb, JeanelleMountain West parental atitudes and barriers related to HPV vaccination in rural settingsHPV is the most common sexually transmitted infection (STI) in the United States and can cause the following cancers: cervical, vulvar, vaginal, penile, anal and oropharyngeal. There is a vaccine to prevent 9 strains of HPV most commonly associated with cancer and genital warts. Unfortunately, rates...2021
27 Vlasic, KajsaStorytelling and the patient experience: Narratives of breast cancer survivorsThrough my young life, I have been fortunate enough to be surrounded and supported by a loving and extended family of mothers. Although I will only have one biological mom, I have collected other women as role models and confidantes who have guided and spoken words of encouragement through my most i...Breast cancer patients' writings2014-12
28 Peterson, JohnPotential Therapeutic Inhibition of Epigenetic Modulator LSDI in Glioblastoma MultiformeGlioblastoma (GBM) is the most common primary brain tumor in adults, and while advances in surgery, radiation, and standard chemotherapies have improved survival in this disease marginally over the years, the outcomes for most patients remain disappointing (Bhat, 2013). Recent studies have identifie...
29 Bender, AustinThe role of ornithine, polyamines, and amino acid accumulation in the growth of melanomaA frequent adaptation in the development of melanoma is the downregulation of argininosuccinate synthetase 1 (ASS1), the rate limiting enzyme in the production of the amino acid arginine from citrulline and aspartate. It is known that ASS1 is required for cells to proliferate in the absence of argin...2024
30 Waller, Rosalie G.Exome sequence comparison of seventy-seven multiple myeloma cases identifies potential risk allelesMultiple Myeloma (MM) is a heritable cancer of plasma cells with poor prognosis. Although a few genomic risk-loci have been identified for MM, no risk variants have been published that explain MM heritability. We hypothesize MM heritability is due to rare germ-line variants that can be discovered th...Multiple myeloma -- Genetic aspects; Exomes; Exome sequence; Risk alleles2015-05
31 Weaver, BradleyHypoxia and the mesenchymal transition in gliomaRecent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum...Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition2014-04
32 Mann, SaraApplying the theory of planned behavior to aggressive treatments at the end-of-lifePhysicians and other health care experts are continuously studying the efficacy of treatments and their long-term effects. For instance, research has shown that aggressive end-of-life care could be potentially more harmful to the patient than previously known. Naturally, this has led to a wave of ...Terminal care; Death2016-04
33 Turner, JoselynAccurate communication : explaining a medical technology to a mass audienceThe purpose of this thesis project is to describe the process I have taken, and that others could follow, to use the written communication tecliniques that I have learned during my undergraduate career to accurately inform a non-medically trained mass audience of a medical technology. Clear communic...Medical technology; Communication and technology2013-05
34 Javdan, ShwanTargeted HPMA copolymer-gemcitabine conjugates for the treatment of ovarian carcinomaEach year in the United States, over 14,000 women die from ovarian cancer. Anthracyclines-a class of chemotherapeutics-have long been the primary treatment for this and many other cancers, yet they often leave patients with cardiotoxicity, hepatotoxicity, and a number of other adverse effects. Polym...Ovaries -- Cancer -- Treatment; Polymeric drug delivery systems; Polymer-drug conjugates; pHPMA2015-12
35 Arave, Rowan A.AKT1 activation promotes the development of melanoma metastasisMetastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu...Melanoma - Genetics - Research; Metastasis - Genetics - Research; Biochemistry; Genetics2015-12
36 Evans, Kathryn S.Defining the interaction between ETV4 and mediator subunit MED25Chromosomal rearrangements resulting in an overexpression of a subset of ETS transcription factors (ETV1, ETV4, ETV5, and ERG) are found in over 50% of prostate cancers (Tomlins et al., 2005). ERG and ETV1 have both shared and distinct gene targets, yet overexpression of ETV1 is often found to be as...Transcription factors; Prostate -- Cancer -- Genetic aspects; ETV42015-05
37 Gaykowski, Logan SaraBirth Control and Depression: Science VS. the MediaPrevious research has shown that the media can have a large effect on how readers internalize news and information, as well as on their choices, opinions and behaviors. Research has also shown that the media often reports scientific findings inaccurately or not in their entire form, providing reader...2017
38 Kodele, ChristianMultivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma CellsNon-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon...2018
39 Kenney, DevinMonumental failure: the navajo tribe and radiotoxic wastesThe extraction of uranium has a troubled history in the Navajo Nation, a history born of lack of representation, lack of interest, and ultimately, lack of regard for human life. The United States government failed to carry out their obligation to protect the health and economic well-being of the Nav...Navajo Tribe - Government relations; Uranium mines and mining - Environmental aspects - United States; Uranium mines and mining - Waste disposal - Navajo Indian Reservation2012-05
40 Cowley, JacobOptimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynesIn order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the...2021
41 Rodriguez, MayraHospital Acquired Bloodstream Infections in Pediatric Patients Undergoing Hematopoietic stem Cell TransplantationPurpose The purpose of this thesis was to investigate hospital acquired bloodstream infections, in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT), using a subset of data from an ongoing study. The goal of the larger study was to track changes in central line-associated ...2020
42 Hodgson, Keeton R.Accelerating DNA Sequence AlignmentPrecision medicine can provide breakthroughs in current medical technology and treatment. The ability to prescribe a speci#12;c cure to a speci#12;c disease for a spe- ci#12;c person can greatly reduce the cost of medical treatments, reduce mistakes in the medical #12;eld, and increase the e#11;ecti...2018
43 Buchanan, Kathryn LeighDeveloping and Evaluating a Resilience Curriculum for Nurse Residency ProgramsPurpose: There is a nursing shortage worldwide, which is partially due to nurses leaving the workforce prematurely. This phenomenon has been particularly prevalent within emergency, critical care, and oncology. This burnout has been linked to a concept termed "compassion fatigue", where nurses' abil...2017
44 Watkins, Ryan DavisSuppression of lymphangiogenesis using VEGF-C trapThe lymphatic system is responsible for controlling systemic fluid buildup. Lymphangiogenesis is a dynamic process involving sprouting, and maintaining new lymphatic vasculature. Vascular endothelial growth factor C (VEGF-C) is as a key growth factor that induces lymphangiogenesis by binding VEGF re...Lymphatics - Growth; Vascular endothelial growth factors - Antagonists; Lymphangiogenesis; VEGF-C trap2014-05
45 Scholes, Connor G.The Ethics of Uncertainty in Clinical Genetics TestingRecent years have seen the explosive development of genetics and its subsequent use in medical practice. In the face of such rapid technological advancement that impacts the health of thousands each year and constitutes a multi-million-dollar industry, ethical analysis of the various shortcomings th...2019
46 Tara L. DeansUnraveling the Q system function in prokaryotes2024
47 Armstrong, Blair P.Lower critical solution temperature behavior of elastin-coiled-coil polymer, a potential platform for treatment of non-hodgkin's lymphomaNon-Hodgkin's lymphoma takes the lives of 20,000 Americans each year. When traditional therapies fail, clinicians have turned to a drug, rituximab, for treatment. However, rituximab is now curative for less than 50% of patients and new treatments are needed. Drug-free macromolecular therapeutics (DF...2021
48 Ong, ElaineIdentifying Natural Genetic Modifiers of Apoptosis and Retinal DegenerationApoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ...2018
49 Estrella, ItzelRadiation doses for Nuclear Medicine Procedures: a Compiled ResourceMany types of diagnostic and therapeutic imaging in nuclear medicine require radiation as an essential part of the procedure. These entail different amounts of dose and exposure to the patient. Doctors, technologists, and patients in nuclear medicine often wonder how much dose and exposure is associ...2017
50 Inglesby, KelseyHealthcare innovation: An examination of process improvementThe term healthcare innovation has been floating around different healthcare systems for quite some time, but it is becoming more and more common for healthcare systems to place an emphasis on innovation in their company. There are many forms of healthcare innovation, three forms of innovation will ...Health care reform; Healthcare innovation2015-05
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