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1 Tang, AnnaMathematical model of drug resistance in ER+ breast Cancer: the role of the microenvironmentOne of the main obstacles to treating cancer is its ability to evolve and resist treatment. In this project, we are primarily interested mathematically modeling how the cancer microenvironment interacts with cancer cells and affects cancer's response to therapy. We aim to develop the mathematical mo...2023
2 Simonsen, KyleBreast cancer knowledge and attitudes among women in ArmeniaBackground: Breast cancer, the most common invasive cancer among women, has high incidence and mortality rates among women in the Republic of Armenia. Advanced stage at detection limits treatment options and contributes to high morbidity and mortality. Understanding women's breast cancer knowledge a...Breast - Cancer; Breast - Cancer - Patients - Attitudes; Breast - Cancer - Patients - Armenia (Republic)2013-07
3 Lindley, ClaraPre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: results from the colocare studyBackground Patients with colorectal cancer commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score. Methods N = 315 patients (sta...2023
4 Esposito, CamilaAxl Inhibitors for Pancreatic Cancer TreatmentBackground: In the United States more than 46,000 people will be diagnosed with pancreatic cancer. Although it is relatively rare, pancreatic cancer is the 4th leading cause of cancer death in men and women. Gemcitabine, the most common treatment for pancreatic cancer has less than 10% partial respo...Pancreas - Cancer - Research2016-05
5 Bethards, KylieAnalysis of AYA cancer patient priority symptoms through text mining softwareBackground Adolescents and young adults (AYAs) with cancer face frightening and often debilitating effects of their cancer. To support the care of AYAs, healthcare providers need to understand their distinct experiences, including their priority symptoms -- those that take the forefront of a pa...2021
6 Richards, GraceMy lung health: shared decision making for lung cancer screeningLung cancer is the deadliest cancer in the United States. In 2019, around 140,000 deaths occurred in the Untied States due to lung cancer. Low-dose CT screening to detect lung cancer is an effective tool for preventing these deaths, but the screening has some harms associated with it in addition to ...2023
7 Terrell, MakennaSymptom Experiences of Adolescents and Young Adults with CancerBackground/Objectives: Adolescents and young adults (AYAs) with cancer are a patient population that is oftentimes overlooked. The symptoms that they experience as a result of their cancer and cancer treatment negatively impact their quality of life. The purpose of this study was to analyze the prio...2019
8 Usman, MinahilPediatric Oncology patients' conceptualization of cancer symptomsCancer treatments often involve intense and difficult procedures which can make children feel distressed while also disrupting their quality of life (Woodgate, 2008). Their ability to participate in daily activities becomes severely restricted and relationships with parents and siblings are also str...2023
9 Sharma, KapilAnalyzing the relationship between PDM2 and B-catenin proteins in human cancersTumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance...Pyruvate kinase - Research; Tumorigensis - Research2016-04
10 Rohaj, AarushiApoptosis efficiency of the transfected elephant and human P35 vectors in P53 varying leiomyosarcoma cellsComparative Oncology is an approach that integrates and connects commonly occurring cancers seen in animals, into studies focused on cancer biology, prevention, and treatment in humans. Studies show that natural mechanisms can suppress cancer 1,000 times more adequately in certain animals than in hu...Doxorubicin; vectors2021
11 Hansen, MasonInterferon gamma inducible nampt and its role in resisting cancer cell growthThe tumor microenvironment (TME) is very complex and important due to its ability to influence the response of therapies on tumors. Immune cells infiltrate the TME and secrete inflammatory cytokines, such as interferon-gamma (IFNg), which help activate the immune system. This activation leads to an ...2023
12 Radhakrishnan, ParvathiPI3K inhibitors as potential new therapy against breast cancer progressionReceptor tyrosine kinases (RTKs) and their pleiotropic effectors play key roles in metastasis. Met and Ron are RTKs that have been shown to contribute to tumor growth and metastasis in both animal models and in patients. Recently, an alternative Ron isoform known as "short-form" Ron (sfRon) was asso...Breast - Cancer - Treatment - Research; Protein - tyrosine kinase - inhibitors - Therapeutic use; Enzyme inhibitors - Therapeutic use. - Research; Biology - Research2014-05
13 Trakhimets, AlesiaPre-clinical trials of anti-neoplastic drugs using zebrafish with T-cell cancerNote: To agree with NCBI nomenclature guidelines, human gene abbreviations are italicized and capitalized; human protein abbreviations are non-italicized and capitalized, and zebrafish gene abbreviations are italicized in lowercase. T lymphocytes, or T-cells, are blood cells that normally fight vira...Antineoplastic agents - Testing; Zebra danio2013-04
14 Farnsworth, JenniferAn exploration of narrative medicine with pediatric cancer patients using a symptom tracking APPThis exploration places a special focus on narrative as a means of restoring empathy and understanding to medical care, especially to a population so vulnerable to confusion and miscommunication - children. The larger project, from which this thesis project is derived, is the development and evaluat...2021
15 Neville, RoselynConstitutively activated AKT is not sufficient to keep cells alive following epithelial cell extrusionThe PI3 kinase (PI3K)/AKT signaling pathway regulates many fundamental behaviors of the cell. If any of the key members of this pathway are deregulated, it can lead to malignant changes in the cell. AKT enhances the survival of cells by inhibiting pro-apoptotic processes, and promoting pathways for ...PI3K/AKT - Chemistry; Cancer metastasis2014-05
16 Narasipura, Eshan AmruthFull synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycinTargeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-...2021
17 Meaux, Scott AlanBorders of immunity redefined under the scope of scaleBorders. A line in the sand as it were, a place with a definite beginning and a hazy ending. Whether respected or disregarded, an entity that most simply can't ignore. The choice to see them as helpful or to ensure harm, divisiveness washes away all connotation. Often defined in the classroom as an ...2022
18 Maciel, AlexaAn examination of chronic patients receiving psychosocial support through online health communitiesPeople living with chronic diseases are increasingly utilizing the internet for healthrelated reasons. The existence of Online Health Communities (OHCs) allows for chronic patients to easily connect with similarly diagnosed patients and keep track of medical records. The purpose of this thesis is to...2021
19 Kannan, Sarmishta DiraviamThe Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial SarcomaSarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph...2017
20 Adams, Samuel I.Correcting acoustic phase aberrations in focused ultrasound treatments for breast cancerBreast cancer is the most diagnosed cancer worldwide. Early-stage localized cancers are currently treated with surgical lumpectomy and radiation. Focused ultrasound is a disruptive technology that can replace conventional surgical and radiation therapies to provide noninvasive cancer treatment. This...2021
21 Tripathy, AnuragNickel-Functionalized Solid-State Titania Nanotube Array for the Electrochemical Detection of Breath-Based Biomarkers in Colorectal CancerColorectal cancer (CRC) is the second most common cancer in the United States with approximately 137,000 new cases each year, 50,000 of which are fatal due to belated screenings [1]. The gold-standard detection method is colonoscopy, a direct visualization tool that facilitates the removal of minor ...2019
22 Khuu, ScottIdentifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal TransitionCancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski...2017
23 Reimers, NoelleExploring the role of lipied metabolism in hepatocellular carcinomaHepatocellular carcinoma (HCC) is an aggressive cancer with poor survival rates and limited treatment options whose prevalence is expected to increase up to 137% by 2030. Existing therapies outside of liver resection or transplantation have poor efficacy, and few new treatment options have been deve...2021
24 Loftus, Patrick D.Agonist binding of herg K+ channels inhibits epithelial cell extrusion but not apoptosis in MDCK monolayers; providing possibilities to cancer metastasis regulationMetastasis is commonly referred to as cancerous cell movement from an original site to one or more sites elsewhere in the body. When these moving cancerous cells are malignant, an individual's chance of survival is decreased. In order for epithelial cells to move they are detached from the epitheliu...Biomedical Engineering2012-01
25 Kendell, IsaacImmunomodulation improves cancer cell clearance by T cells during multi-antigent T cell hybridizer therapyTreatment of hematopoietic malignancies is challenging due to systemic side effects of current treatments and the possibility of relapse. Multi-antigen T cell hybridizer (MATCH) therapy is a novel treatment system composed of antibody fragments conjugated with morpholino oligonucleotides, which hybr...2024
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