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1 Johnson, Nicholas J.The inflation reducation act's medicare part D drug price negotiation: an unlikely outcomeThe Inflation Reduction Act (IRA) was signed into law on August 16, 2022, and the passage of this unassuming piece of legislation marks one of the most important advancements in health care policy in the United States. A key component of the law is its efforts to increase access and affordability of...Medicare part d; inflation reduction act; drug price negotiation2024
2 Gates, AbigailHealth Care in the United States: Disparities and Distrust in the Black CommunityDuring the time of slavery, Black and African Americans were mistreated and abused as research subjects in medical studies. This mistreatment continued into the 20th century with the Tuskegee Syphilis study and continues today in many doctor's offices throughout America. This paper begins by looking...2020
3 Pecchia-Bekkum, AnnikaApplications of controlled DNA assembly and disassembly in biosensing and responsive drug deliveryDeoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In...Nucleic acids; biotechnology2013-08
4 Reimers, NoelleExploring the role of lipied metabolism in hepatocellular carcinomaHepatocellular carcinoma (HCC) is an aggressive cancer with poor survival rates and limited treatment options whose prevalence is expected to increase up to 137% by 2030. Existing therapies outside of liver resection or transplantation have poor efficacy, and few new treatment options have been deve...2021
5 Ballif, MicahDrugs and Pregnancy: Clinical Management with a Cystic Fibrosis FocusDespite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise...Physicians; University of Utah Hospital's; antibiotics2019
6 Larson, BrookeChacterization of signaling to the degradative pathways of the cellProtein degradation in cells is a complex network of pathways that are distinct from each other but highly interconnected. Understanding how proteins are degraded in cells is important for understanding and developing treatments for diseases such as lysosomal storage diseases and neurodegenerative d...2023
7 Radhakrishnan, ParvathiPI3K inhibitors as potential new therapy against breast cancer progressionReceptor tyrosine kinases (RTKs) and their pleiotropic effectors play key roles in metastasis. Met and Ron are RTKs that have been shown to contribute to tumor growth and metastasis in both animal models and in patients. Recently, an alternative Ron isoform known as "short-form" Ron (sfRon) was asso...Breast - Cancer - Treatment - Research; Protein - tyrosine kinase - inhibitors - Therapeutic use; Enzyme inhibitors - Therapeutic use. - Research; Biology - Research2014-05
8 Amaechi, AyanaUnderstanding sex differences in early predictors of pathological aggression with a mouse modelAntisocial behavior (ASB) is characterized by aggression, violence, drug use, thrillseeking behavior, and delinquent behavior. While childhood and adolescent maltreatment contribute to the ontogeny of this condition, converging evidence suggests that genetic factors play an equally important role. T...MAOA; pathological aggression; sex differences; stress; early development; animal models2021
9 Davis, Kacey A.Expression and Purification of Augertoxins: Searching for Novel Protein Folds in Venomous Marine SnailsThis study describes a method for bacterial expression and purification of previously uncharacterized proteins. The proteins chosen for this study come from auger snail toxins, which have evolved to help the snail hunt and kill their prey. Evolutionary pressure between predator and prey selects for ...2018
10 Cowley, JacobOptimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynesIn order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the...2021
11 Ingold, AlexanderDevelopment of a Utah optrode array for large scale optogenetics in non-human primate cortex: analysis of spatial excitation pattern using C-FOS expressionA central goal in neuroscience is to understand how neural circuits generate the computations that underlie neuronal responses, sensory perception, and behavior. This requires manipulating their activity and determining the results of these manipulations. Optogenetics is a versatile laboratory techn...2022
12 Stewart, PatrickA Real-World Investigation of the Attentional Capture ParadigmAttention directs awareness toward important objects, like food or predators, and filters out unimportant objects, like familiar scenery. Two modes of visual attention have been identified: goal-directed and stimulus-driven (Simons, 2000). Goal-directed attention refers to a deliberate search for ob...2017
13 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
14 Kodele, ChristianMultivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma CellsNon-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon...2018
15 Meaux, Scott AlanBorders of immunity redefined under the scope of scaleBorders. A line in the sand as it were, a place with a definite beginning and a hazy ending. Whether respected or disregarded, an entity that most simply can't ignore. The choice to see them as helpful or to ensure harm, divisiveness washes away all connotation. Often defined in the classroom as an ...2022
16 Austin, Maxwell JackTriazolinedione-Based methods for peptide cyclization and efforts toward the total synthesis of (-)-BiotinChapter 1 presents the development of a triazolinedione-based, tyrosine-selective method to cyclize short- to medium-sized peptides. The development of efficient conditions to prepare precursor ‘urazole' peptides is discussed. Preliminary efforts to oxidize and cyclize urazole peptides are discuss...2023
17 Davidson, OliviaUtilizing synthetic biology to improve platelet transfusion outcomesPlatelets are essential to blood clotting. Due to a high risk of bacterial infection, donor platelets have short shelf -lives. As a result, being able to maintain a constant supply of platelets in vitro would be clinically valuable. This could be accomplished by using synthetic biology to guide stem...Blood platelets - Transfusion - Research; Stem cells - Therapeutic use; Synthetic biology; Hematopoietic stem cells; Erthropoientin2016-05
18 Martinez, TravisInvestigative work in antibiotic treatment of biofilms using a new reactor modelBiofilms are notoriously tolerant to antibiotics and a growing problem in modern healthcare, yet the inaccessibility of biofilm reactors hinders research in many instances. Existing biofilm reactors remain costly, time-consuming, and dependent on difficult-tomanage resources. To address this issue, ...2024
19 Hansen, MasonInterferon gamma inducible nampt and its role in resisting cancer cell growthThe tumor microenvironment (TME) is very complex and important due to its ability to influence the response of therapies on tumors. Immune cells infiltrate the TME and secrete inflammatory cytokines, such as interferon-gamma (IFNg), which help activate the immune system. This activation leads to an ...2023
20 Schlegel, Isabelle B.Peptide-fab conjugates to improve treatment of neovascular age-related macular degenerationAge-Related Macular Degeneration (AMD), a chronic disease of the eye and leading cause of blindness in Americans over 50, is often treated with agents that inhibit Vascular Endothelial Growth Factor (VEGF). Ranibizumab is an anti-VEGF antibody fragment (Fab) effective at treating over 90% of AMD pat...2021
21 Gallegos, MorganHerThis creative exploration is a study of how a girl comes to identify herself in an increasingly judgmental and harsh world. Her is a collection of short stories that are linked together through one character. The stories are intentionally fragmented to display the fragmentary nature of identity. Eac...American fiction - 21st century2012-05
22 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
23 Kehr, DavidAbnormal Stock Returns and Venture Capital Funding Event Study of Six Down Round Venture Capital Funding Announcement DatesThis paper analyzes the reaction of stock prices to the announcement of a round of financing raised by a venture capital-backed firm at a valuation lower than in a previous round. The event study is performed to analyze short-term stock price reactions prior to and following the announcement of a do...2018
24 Vetter, MikeyInhibition of FAK and AKT as potential therapies for melanoma brain metastasisBrain metastasis is the leading cause of death in patients with advanced melanoma. Melanoma diagnoses nearly reached 100,000 in 2019, and melanoma patients make up 10% of all patients with brain metastasis [1]. The roles of the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinos...vehicle control; previously2021
25 Kendell, IsaacImmunomodulation improves cancer cell clearance by T cells during multi-antigent T cell hybridizer therapyTreatment of hematopoietic malignancies is challenging due to systemic side effects of current treatments and the possibility of relapse. Multi-antigen T cell hybridizer (MATCH) therapy is a novel treatment system composed of antibody fragments conjugated with morpholino oligonucleotides, which hybr...2024
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