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TitleCreatorDescriptionSubject
1 Upbeat NystagmusRaed Behbehani, MD,A patient with a brain stem syndrome due to demyelination and upbeat nystagmus.Upbeat Nystagmus
2 Upbeat NystagmusShirley H. Wray, MD, PhD, FRCPThe patient, a 36 year old Italian, presented in October 1967, at the age of 27, with acute dizziness and ataxia. He was evaluated in Rome. A pneumoencephalogram showed hydrocephalus, attributed to arachnoiditis, and a ventriculo-atrial shunt was placed. Three months post shunt placement he had a re...Upbeat Nystagmus; Saccadic Hypermetria; Saccadic Pursuit; Square Wave Jerks; Oscillopsia; Cerebellar Astrocytoma; Primary Position Upbeat Nystagmus; Horizontal Saccadic Dysmetria
3 Bilateral Internuclear OphthalmoplegiaShirley H. Wray, MD, PhD, FRCPSlideshow describing condition.Abducting Nystagmus; Bilateral Internuclear Ophthalmoplegia; Botulinum Toxin Therapy; Gaze Evoked Upbeat Nystagmus; Horizontal Pendular Nystagmus; Lid Nystagmus; Multiple Sclerosis; Pendular Horizontal Oscillations; Upbeat Nystagmus
4 Bilateral Internuclear OphthalmoplegiaShirley H. Wray, MD, PhD, FRCPThis patient was seen at the Yale Eye Center at the age of 37. She had a long history of multiple sclerosis. At age 22, she had an acute attack of optic neuritis in the left eye which recovered fully within three weeks. Some months later she had a recurrent episode in the same eye, which also recove...Bilateral Internuclear Ophthalmoplegia; Pendular Horizontal Oscillations; Lid Nystagmus; Upbeat Nystagmus; Botulinum Toxin Therapy; Multiple Sclerosis; Horizontal Pendular Nystagmus; Gaze Evoked Upbeat Nystagmus; Abducting Nystagmus
5 Multiple SclerosisShirley H. Wray, MD, PhD, FRCPThe patient is a 56 year old woman who presented in 1982, at the age of 48, with a one week history of painless loss of vision in the left eye. Past History: Negative for a previous attack of optic neuritis or transient neurological symptoms. Family History: Negative for CNS disease Neuro-ophthalmol...Upbeat Nystagmus; Lid Nystagmus; Square Wave Jerks; Jerk Oscillations; Rotary Nystagmus; Saccadic Pursuit; Saccadic Dysmetria; Multiple Sclerosis; Bilateral Lid Nystagmus; Primary Position Upbeat Nystagmus; Torsional Nystagmus; Horizontal Saccadic Dysmetria
6 Internuclear Ophthalmoplegia in ChildhoodShirley H. Wray, MD, PhD, FRCPPowerPoint slideshow describing the condition.Abducting Nystagmus; Bilateral Internuclear Ophthalmoplegia; Medulloblastoma; Upbeat Nystagmus
7 Lessons From Bench BedsideShirley H. Wray, MD, PhD, FRCPSee also: http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/69, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/282, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/94, and http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/103Bilateral Internuclear Ophthalmoplegia; Pendular Horizontal Oscillations; Lid Nystagmus; Upbeat Nystagmus; Botulinum Toxin Therapy; Multiple Sclerosis; Horizontal Pendular Nystagmus; Gaze Evoked Upbeat Nystagmus; Abducting Nystagmus; Normal Convergence; Gaze Evoked Downbeat Nystagmus; Sac...
8 Brainstem Cavernous AngiomaShirley H. Wray, MD, PhD, FRCPSlideshow describing condition.Bilateral Horizontal Gaze Palsy Hemorrhage; Bilateral Lid Nystagmus; Cavernous Angioma; Hiccup; Horizontal Gaze Evoked Nystagmus; Lid Nystagmus; Medulla Hemorrhage; Medullary Hemorrhage; Primary Position Upbeat Nystagmus; Upbeat Nystagmus
9 Multiple SclerosisShirley H. Wray, MD, PhD, FRCPSlideshow describing condition.Bilateral Lid Nystagmus; Horizontal Saccadic Dysmetria; Jerk Oscillations; Lid Nystagmus; Multiple Sclerosis; Primary Position Upbeat Nystagmus; Rotary Nystagmus; Saccadic Dysmetria; Saccadic Pursuit; Square Wave Jerks; Torsional Nystagmus; Upbeat Nystagmus
10 Thiamine (Vitamin B1) Deficiency (Video)Nirupama Devanathan; Devin D. Mackay, MD33-year-old female who initially presented with heat stroke that was thought to provoke cyclical vomiting over the course of 6 weeks, perpetuated by anxiety, resulting in a 15- pound weight loss. She presented to the ED with bilateral vision loss, bilateral lower extremity weakness and vertical nyst...Thiamine; Upbeat Nystagmus; Nutritional Optic Neuropathy; Wernicke Encephalopathy
11 Brainstem Cavernous AngiomaShirley H. Wray, MD, PhD, FRCPThe patient is a 50 year old woman who presented in November 1977 with a transient facial droop, nystagmus, diplopia, dysarthria and vertigo. She was admitted to New England Tufts Medical Center and had an extensive workup including an electroencephalogram, first generation CT brain scan, angiogram ...Upbeat Nystagmus; Lid Nystagmus; Horizontal Gaze Evoked Nystagmus; Hiccup; Medullary Hemorrhage; Cavernous Angioma; Bilateral Lid Nystagmus; Bilateral Horizontal Gaze Palsy Hemorrhage; Primary Position Upbeat Nystagmus; Medulla Hemorrhage; Medulla
12 Paraneoplastic Upbeat NystagmusShirley H. Wray, MD, PhD, FRCPThis case was presented to the Clinical Eye Movement Society at the American Neurological Association Meeting in October 2009. The patient is a 65 year old woman who was in good health until seven weeks prior to admission. On June 22/09 on the return flight from her daughter's wedding in Oregon she ...Upbeat Nystagmus; Lid Nystagmus; Square Wave Jerks (Saccadic Oscillations); Saccadic Dysmetria; Saccadic Pursuit; Paraneoplastic Syndrome; Paraneoplastic Upbeat Nystagmus; Pancreatic Endocrine Carcinoma; Anti-Hu - Associated Paraneoplastic Encephalitis
13 Internuclear Ophthalmoplegia in Childhood (Guest Lecture)Shirley H. Wray, MD, PhD, FRCPThis case was reported by Cogan DG and Wray SH. Internuclear ophthalmoplegia as an early sign of brain tumor. Neurology 1970; 20:629-633. The patient is Case 1. He is a 4 ½ year old boy whose parents noted that the right eye had been "drifting" for four months. On examination the only significant f...Bilateral Internuclear Ophthalmoplegia; Upbeat Nystagmus; Medulloblastoma; Abducting Nystagmus
14 Multiple Sclerosis 2008: Bench to Bedside….and Back Again, The Raymond Adams LectureStephen L. Hauser, MDSlideshow describing condition.Abducting Nystagmus; Bilateral Internuclear Ophthalmoplegia; Botulinum Toxin Therapy; Gaze Evoked Downbeat Nystagmus; Horizontal Pendular Nystagmus; Horizontal Saccadic Dysmetria; Lid Nystagmus; Multiple Sclerosis; Normal Convergence; Oscillopsia; Pendular Horizontal Oscillations; Saccadic Dysmetri...
15 Paraneoplastic Upbeat NystagmusShirley H. Wray, MD, PhD, FRCPA PowerPoint slideshow describing the condition.Anti-Hu - Associated Paraneoplastic Encephalitis Ataxia; Horizontal Saccadic Dysmetria; Lid Nystagmus; Oscillopsia; Pancreatic Endocrine Carcinoma; Paraneoplastic Cerebellar Syndrome; Paraneoplastic Upbeat Nystagmus; Primary Position Upbeat Nystagmus; Saccadic Dysmetria; Saccadic Pursuit; Square Wa...
16 Brain MRI in Multiple SclerosisAnne G. Osborn, MDSlideshow describing condition.Abducting Nystagmus; Bilateral Internuclear Ophthalmoplegia; Botulinum Toxin Therapy; Gaze Evoked Downbeat Nystagmus; Horizontal Pendular Nystagmus; Horizontal Saccadic Dysmetria; Lid Nystagmus; Multiple Sclerosis; Normal Convergence; Oscillopsia; Pendular Horizontal Oscillations; Saccadic Dysmetri...
17 Upbeat NystagmusShirley H. Wray, MD, PhD, FRCPSlideshow describing condition.Bilateral Lid Nystagmus; Bulbar Palsy; Cerebellar Astrocytoma; Cervical Myelitis; Horizontal Gaze Evoked Nystagmus; Horizontal Saccadic Dysmetria; Opsoclonus; Oscillopsia; Post Infectious Brainstem Encephalitis; Primary Position Upbeat Nystagmus; Saccadic Hypermetria; Saccadic Pursuit; Square Wave ...
18 Thiamine (Vitamin B1) Deficiency (Presentation)Nirupama Devanathan; Devin D. Mackay, MDOverview of thiamine deficiency and its neuro-ophthalmic manifestations with an illustrative case example and discussion of clinical presentation, relevant biochemistry, testing, risk factors, and treatment. Corresponding Video: https://collections.lib.utah.edu/details?id=2297569Thiamine; Upbeat Nystagmus; Nutritional Optic neuropathy; Wernicke Encephalopathy
19 One and a Half SyndromeShirley H. Wray, MD, PhD, FRCPThis 44 year old woman presented in 1973 with an acute attack of optic neuritis in the right eye that fully recovered after a course of ACTH therapy. In 1991, 18 years later, she developed unsteadiness of gait, "walking like a chicken", stiff legs that jerked spontaneously in bed at night, and numbn...Unilateral Internuclear Ophthalmoplegia; Unilateral Horizontal Gaze Palsy; Upbeat Nystagmus on Upgaze; Convergence Normal; Fisher's One-and-a-Half Syndrome; Uhthoff's Symptom; Multiple Sclerosis; Unilateral Horizontal Gaze Palsy Demyelination; Gaze Evoked Upbeat Nystagmus; Abducting Nystagmus
20 Brain MRI in Multiple Sclerosis (Guest Lecture)Anne G. Osborn, MDThe patient is a 25 year old woman who was in excellent health until 4 days prior to admission when she noted blurred vision and horizontal double vision on lateral gaze to right and left. Past History: Negative for strabismus as a child. No previous episodes of transient neurological symptoms. Fami...Bilateral Internuclear Ophthalmoplegia; Abducting Nystagmus; Normal Convergence; Gaze Evoked Upbeat Nystagmus; Gaze Evoked Downbeat Nystagmus; Saccadic Dysmetria; Multiple Sclerosis; Horizontal Saccadic Dysmetria
21 One and a Half SyndromeShirley H. Wray, MD, PhD, FRCPSlideshow describing condition.Abducens Nuclear Lesion; Abducting Nystagmus; Cavernous Angioma; Convergence Absent; Convergence Normal; Esotropia; Facial Palsy; Facial Weakness; Fisher's One-and-a-Half Syndrome; Gaze Evoked Upbeat Nystagmus; Multiple Sclerosis; Pendular Vertical Oscillations; Pontine Hemorrhage; Pontine Infarct;...
22 Cavernous AngiomaShirley H. Wray, MD, PhD, FRCPThe patient is a 19 year old sophomore who presented in 1983 with numbness of the left hand, involving initially just the fingers, and numbness and weakness of the right side of the face. He described the numbness in his hand as if it was "intensely asleep". The facial numbness involved the perioral...Unilateral Internuclear Ophthalmoplegia; Unilateral Horizontal Gaze Palsy; Upbeat Nystagmus on Upgaze; Convergence Normal; Pendular Vertical Oscillations; Facial Palsy; Fisher's One-and-a-Half Syndrome; Pontine Hemorrhage; Cavernous Angioma; Unilateral Gaze Palsy Hemorrhage; Abducting Nystagmus; Fac...
23 Pontine InfarctionShirley H. Wray, MD, PhD, FRCPSlideshow describing condition.Abducting Nystagmus; Convergence Normal; Fisher's One-and-a-Half Syndrome; Pontine Infarct; Unilateral Horizontal Gaze Palsy Infarct; Unilateral Horizontal Gaze Palsy; Unilateral Internuclear Ophthalmoplegia; Upbeat Nystagmus on Upgaze
24 Cavernous Sinus MeningiomaShirley H. Wray, MD, PhD, FRCPSlideshow describing condition.Abducting Nystagmus; Cavernous Angioma; Convergence Normal; Facial Palsy; Facial Weakness; Fisher's One-and-a-Half Syndrome; Pendular Vertical Oscillations; Pontine Hemorrhage; Unilateral Gaze Palsy Hemorrhage; Unilateral Horizontal Gaze Palsy; Unilateral Internuclear Ophthalmoplegia; Upbeat Nystag...
25 Pontine_InfarctionShirley H. Wray, MD, PhD, FRCPThe patient is a 62 year old right handed man, status post myocardial infarction in 1989 and on Coumadin. In 1993 he presented with a history of three separate TIAs 1.Instantaneous perioral tingling and/or numbness lasting less than 1 minute. 2.Episodic numbness of the right hand and foot lasting le...Unilateral Internuclear Ophthalmoplegia; Unilateral Horizontal Gaze Palsy; Upbeat Nystagmus on Upgaze; Convergence Normal; Fisher's One-and-a-Half Syndrome; Pontine Infarct; Unilateral Horizontal Gaze Palsy Infarct; Abducting Nystagmus
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