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Creator | Title | Description | Subject | Date |
| 1 |
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Gesteland, Raymond F.; Atkins, John F.; Wills, Norma M. | rRNA-mRNA base pairing stimulates a programmed -1 ribosomal frameshift | Base pairing between the 3' end of 16S rRNA and mRNA is shown to be important for the programmed -1 frameshifting utilized in decoding the Escherichia coli dnaX gene. This pairing is the same as the Shine-Dalgarno pairing used by prokaryotic ribosomes in selection of translation initiators, but for ... | Frameshifting; Escherichia coli; Binding Sites; Base Composition | 1994 |
| 2 |
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Gesteland, Raymond F.; Atkins, John F.; Ingram, Jennifer A.; Kelly, Paul J.; Grentzmann, Guido | Dual-luciferase reporter system for studying recoding signals | A new reporter system has been developed for measuring translation coupling efficiency of recoding mechanisms such as frameshifting or readthrough. A recoding test sequence is cloned in between the renilla and firefly luciferase reporter genes and the two luciferase activities are subsequently measu... | Amino Acid Sequence; Genes, Reporter; HIV; Antizyme; Translation | 1998 |
| 3 |
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Baehr, Wolfgang | Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene | Guanylate cyclase-activating protein (GCAP) is a novel Ca(2+)-binding protein that stimulates synthesis of cGMP in photoreceptors. Molecular cloning of human and mouse GCAP cDNA revealed that the known mammalian GCAPs are more than 90% similar, consist of 201-205 amino acids, and contain three ident... | Amino Acid Sequence; Base Sequence; Cloning, Molecular | 1994 |
| 4 |
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Capecchi, Mario R. | Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. | We describe the generation of mammalian cell lines carrying amber suppressor genes. Nonsense mutants in the herpes simplex virus thymidine kinase (HSV tk) gene, the Escherichia coli xanthine-guanine phosphoribosyl transferase (Eco-gpt) gene and the aminoglycoside 3' phosphotransferase gene of the Tn... | Cercopithecus aethiops; Escherichia coli; Xenopus | 1982-11-30 |
| 5 |
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Dailey, Andrew T.; Moore, Kevin R. | Value of MR neurography for evaluating extraspinal neuropathic leg pain: a pictorial essay | Summary: Fifteen patients with neuropathic leg pain referable to the lumbosacral plexus or sciatic nerve underwent high-resolution MR neurography. Thirteen of the patients also underwent routine MR imaging of the lumbar segments of the spinal cord before undergoing MR neurography. Using phased-array... | MR neurography; Neuropathic leg pain; Extraspinal; Lumbosacral plexus | 2001 |
| 6 |
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Normann, Richard A.; Kolb, Helga; Lasater, Eric M. | Signal integration at the pedicle of turtle cone photoreceptors: an anatomical and electrophysiological study | The morphology of the axon which connects the cell body and pedicle of turtle cone photoreceptors was studied by light and electron microscopy. The axon which contains numerous synaptic vesicles, some endoplasmic reticulum, and a few cisternae is basically filled with cytoplasm. The length of the ax... | Cone Photoreceptor, Voltage Clamp; Isolated Cells; Input Resistance; Cell Body-Pedicle Coupling | 1989 |
| 7 |
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Gesteland, Raymond F.; Atkins, John F. | Influence of the stacking potential of the base 3' of tandem shift codons on -1 ribosomal frameshifting used for gene expression | Translating ribosomes can shift reading frame at specific sites with high efficiency for gene expression purposes. The most common type of shift to the 1 frame involves a tandem realignment of two anticodons from pairing with mRNA sequence of the form X XXY YYZ to XXX YYY Z where the spaces indicate... | 1 frameshifting; 39 context effect; Codon anticodon interaction; Escherichia coli ; Recoding; tRNALys; XXXY YYZ frameshift motifs | 2002 |
| 8 |
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Mitchell, Joyce A. | Retrieval from full-text medical literature: the dream & the reality | While the retrieval of the full-text of a document might seem to end all the hassle of using traditional retrieval systems, the results of the MEDLINE/Full-Text Project indicate that retrieval from the current full-text databases of biomedical journal literature does not match the dream. During the ... | | 1991-01-01 |
| 9 |
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Blumenthal, Donald K. | Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase. | Limited proteolysis has been utilized to study the structural organization of rabbit skeletal muscle myosin light chain kinase. The enzyme (Mr approximately 89,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis) consists of an amino-terminal, protease-susceptible region of unidentified... | Enzymology; Skeletal Muscle; Proteolysis, Peptide Fragments | 1995-09-15 |
| 10 |
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Baehr, Wolfgang; Frederick, Jeanne M.; Church-Kopish, Jill; Howes, Kimberly | Mutant rhodopsin transgene expression on a null background | PURPOSE. To study mechanisms leading to photoreceptor degeneration in mouse models for autosomal dominant retinitis pigmentosa (adRP) based on the rhodopsin P23H mutation. METHODS. Mice of a transgenic line expressing a rhodopsin triple mutant, V20G, P23H, and P27L (GHL), were mated with rhodopsin (... | Mutant Rhodopsin; Photoreceptor Degeneration; Autosomal Dominant Retinitis Pigmentosa; Rhodopsin | 2001-03 |
| 11 |
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Florsheim, Paul W. | Mourning the loss of "self as father": a longitudinal study of fatherhood among the druze | IT is within the context of the parent-child relationship - through the processes of attachment, loss, separation and individuation - that we grow and develop interpersonally and intrapsychically (Bowlby 1969, 1980; Mahler et al. 1975; Pollock, 1989). Most developmentalists agree that changes in th... | | 1992 |
| 12 |
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Baehr, Wolfgang | Annotation and analysis of 10,000 expressed sequence tags from 3 mouse eye cDNA libraries | BACKGROUND: As a biomarker of cellular activities, the transcriptome of a specific tissue or cell type during development and disease is of great biomedical interest. We have generated and analyzed 10,000 expressed sequence tags (ESTs) from three mouse eye tissue cDNA libraries: embryonic day 15.5 (... | Cluster Analysis; DNA, Complementary; Gene Expression Profiling | 2003 |
| 13 |
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Gardner, Reed M. | Frequency of Technical Problems Encountered in the Measurement of Pulmonary Artery Wedge Pressure | Biomedical Informatics | | 1984 |
| 14 |
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Caserta, Michael; Lund, Dale A. | Future directions in adult bereavement research | The primary purpose of this article is to stimulate interest in conducting research related to adult bereavement and provide suggestions for improving the quality of these studies and the application of their findings. Future research needs to generate new knowledge about grief and bereavement but ... | | 1998 |
| 15 |
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Capecchi, Mario R. | Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. | Hypoxanthine-guanine phosphoribosyltransferase (HGPR transferase) (EC 2.4.2.8) has been purified approximately 4500-fold to apparent homogeneity from mouse liver. The procedure involves the use of affinity chromatography and was designed to be readily adaptable to small scale isolations. The enzyme ... | Buffers; Centrifugation, Density Gradient; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel | 1975-01-31 |
| 16 |
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Baehr, Wolfgang | Characterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pineal | PURPOSE: This study had three objectives: (1) to characterize the structures of the chicken GCAP1 and GCAP2 genes; (2) to determine if GCAP1, GCAP2, and GC1 genes are expressed in chicken pineal gland; (3) if GC1 is expressed in chicken pineal, to determine if the GC1 null mutation carried by the re... | Molecular Sequence Data; Promoter Regions (Genetics); Retinal Degeneration | 1999 |
| 17 |
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Normann, Richard A. | Statistical encoding model for a primary motor cortical brain-computer interface | A number of studies of the motor system suggest that the majority of primary motor cortical neurons represent simple movement-related kinematic and dynamic quantities in their time-varying activity patterns. An example of such an encoding relationship is the cosine tuning of firing rate with respect... | Discrete Distribution; LN Model; Neural Decoding; Neuroprosthetics; Sequential Monte-Carlo Filter | 2005 |
| 18 |
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Jones, Bryan W. | Molecular phenotyping of retinal ganglion cells | Classifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutama... | Aspartic Acid/metabolism; Image Cytometry/methods | 2002 |
| 19 |
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Normann, Richard A.; Shoham, Shy | Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion | Recent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ... | Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle | 2004 |
| 20 |
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Bernstein, Paul S.; Gellermann, Werner | Nonmydriatic fluorescence-based quantitative imaging of human macular pigment distributions. | We have developed a CCD-camera-based nonmydriatic instrument that detects fluorescence from retinal lipofuscin chromophores ("autofluorescence") as a means to indirectly quantify and spatially image the distribution of macular pigment (MP). The lipofuscin fluorescence intensity is reduced at all ret... | Cytology; Sensitivity and Specificity | 2006-10 |
| 21 |
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Normann, Richard A.; Branner, Almut | Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve | We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions o... | Cats; Microelectrodes; Prosthesis Implantation; Sciatic Nerve | 2004 |
| 22 |
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Kestle, John R. W.; Simon, Tamara Danielle | Infection rates following initial cerebrospinal fluid shunt placement across pediatric hospitals in the United States | Object. Reported rates of CSF shunt infection vary widely across studies. The study objective was to determine the CSF shunt infection rates after initial shunt placement at multiple US pediatric hospitals. The authors hypothesized that infection rates between hospitals would vary widely even after ... | Shunt placement; Pediatric neurosurgery | 2009 |
| 23 |
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Baehr, Wolfgang | Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons | The second messengers cAMP and inositol-1,4,5-triphosphate have been implicated in olfaction in various species. The odorant-induced cGMP response was investigated using cilia preparations and olfactory primary cultures. Odorants cause a delayed and sustained elevation of cGMP. A component of this c... | Calcium-Binding Proteins; Nerve Tissue Proteins; Rats, Sprague-Dawley | 1998 |
| 24 |
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Varner, Michael W. | Human placental lactogen and other placental proteins as indicators of fetal well-being. | The purpose of this article will be to review the role of hPL and the newer hormones as indicators of fetal well-being. | Human Placental Lactogen; Pregnancy Proteins; Indicators of Fetal Well-Being | 1982-12 |
| 25 |
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Couldwell, William T.; Apfelbaum, Ronald I. | Transoral approach and extended modifications for lesions of the ventral foramen magnum and craniovertebral junction | Objectives: To describe our method of performing the transoral approach and the extended approaches to the ventral foramen magnum and craniovertebral junction and review the technical aspects and operative nuances. Design: Review Results: The transoral approach provides direct midline exposure to a... | Craniovertebral junction; Foramen magnum; Skull base surgery; Transoral approach | 2008 |
