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CreatorTitleDescriptionSubjectDate
1 Fu, YingbinMechanism of reductive activation of potato tuber ADP-glucose pyrophosphorylase.The potato tuber (Solanum tuberosum L.) ADP-glucose pyrophosphorylase activity is activated by a incubation with ADP-glucose and dithiothreitol or by ATP, glucose- 1-phosphate, Ca2+, and dithiothreitol. The activation was accompanied by the appearance of new sulfhydryl groups as determined with 5, 5...Glucosephosphates; Enzyme Activation; Adenosine Triphosphate1998
2 Mitchell, Joyce A.The creation and early implementation of a high speed fiber optic network for a university health sciences centerIn late 1989 the University of Missouri Health Sciences Center began the process of creating an extensive fiber optic network throughout its facilities, with the intent to provide networked computer access to anyone in the Center desiring such access, regardless of geographic location or organizatio...1991-01-01
3 Rondina, Matthew ThomasEmerging evidence for platelets as immune and inflammatory effector cellsWhile traditionally recognized for their roles in hemostatic pathways, emerging evidence demonstrates that platelets have previously unrecognized, dynamic roles that span the immune continuum. These newly recognized platelet functions, including the secretion of immune mediators, interactions with e...2014-01-01
4 Mitchell, Joyce A.Computational Feature of Selection and Classification of RET Phenotypic SeverityAlthough many reported mutations in the RET oncogene have been directly associated with hereditary thyroid carcinoma, other mutations are labelled as uncertain gene variants because they have not been clearly associated with a clinical phenotype. The process of determining the severity of a mutation...2010-01-01
5 Gardner, Reed M.Instrumentation for Computerized Heart CatheterizationBiomedical Informatics1971
6 Warner, Homer R.Health Evaluation Through Logical Processing - HELPBiomedical Informatics1973
7 Mitchell, Joyce A.50 Years of informatics research on decision support: what's nextObjectives: To reflect on the history, status, and future trends of decision support in health and biomedical informatics. To highlight the new challenges posed by the complexity and diversity of genomic and clinical domains. To examine the emerging paradigms for sup - porting cost-effective, person...2011-01-01
8 Rodin, Ernst A.Prognosis of Patients with Epilepsy
9 Rodin, Ernst A.Prognosis of Patients with EpilepsyWritten primarily for the physician who is responsible for the treatment of epileptic patients and the clinical investigator interested in the basic mechanisms underlying this disorder. The book also addresses itself to psychologists interested in the study of mind-brain relationships. Factors relat...epilepsy; epileptic patients; mind-brain relationships1968
10 Blumenthal, Donald K.; Trewhella, JillConformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.Different isoforms of the full-length protein kinase A (PKA) regulatory subunit homodimer (R2) and the catalytic (C) subunit-bound holoenzyme (R2C2) have very different global structures despite similar molecular weights and domain organization within their primary sequences. To date, it has been th...Protein Isoforms; Global Structures; cAMP2005-10-21
11 Jorde, Lynn B.Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: A report from the Childrens Oncology GroupBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and prelimina...2014-01-01
12 Capecchi, Mario R.Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA rec...Animals, Newborn; Crosses, Genetic1997-10-14
13 Mitchell, Joyce A.Bioinformatics linkage of heterogeneous clinical and genomic information in support of personalized medicineObjectives: Biomedical Informatics as a whole faces a difficult epistemological task, since there is no foundation to explain the complexities of modeling clinical medicine and the many relationships between genotype, phenotype, and environment. This paper discusses current efforts to investigate su...2007-01-01
14 Mitchell, Joyce A.Challenges and strategies of the Genetics Home ReferenceObjective: This paper focuses on the first two years of operation of Genetics Home Reference (GHR), a Web-based resource <http://www.ghr.nlm.nih.gov> for the general public that helps to explain the health implications of findings from the Human Genome Project. Methods and Findings: Key challenges o...2006-01-01
15 Couldwell, William T.Multifocal inflammatory leukoencephalopathy associated with levamisole and 5-fluorouracil: case reportLEVAMISOLE AND 5-FLUOROURACIL have now become the standard chemotherapeutic regimen for patients with Stage 111 colon carcinoma. A case of multifocal inflammatory leukoencephalopathy secondary to levamisole alone or combination of levamisole and 5-fluorouracil is reported. Magnetic resonance imaging...Autopsy; Levamisole; Multifocal inflammatory leukoencephalopathy1994
16 Rodin, Ernst A.Prognosis of Patients with Epilepsy
17 Dailey, Andrew T.; Brodke, Darrel S.; Bachus, Kent N.Anterior cervical fixation: analysis of load-sharing and stability with use of static and dynamic platesBackground: Anterior plates provide stability following decompression and fusion of the cervical spine. Various plate designs have emerged, and they include static plates with fixed-angle screws, rotationally dynamic plates that allow the screws to toggle in the plate, and translationally dynamic pl...Anterior cervical fixation; Load-sharing; Stability; Static plates; Dynamic plates2006
18 Mitchell, Joyce A.Predicting phenotypic severity of uncertain gene variants in the RET Proto-OncogeneAlthough reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the associated clinical phenotype is made clear. Cur...2011-01-01
19 Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R.Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...Neuroprogenitor; Embryogenesis2004-11-01
20 Crockett, David K.Utility of gene-specific algorithms for predicting pathogenicity of uncertain gene variantsThe rapid advance of gene sequencing technologies has produced an unprecedented rate of discovery for genome variation in humans. A growing numbered of authoritative clinical repositories archive gene variants and disease phenotype, yet there are currently many more gene variants that lack clear ann...2012
21 Schmidt, Meic H.Cervical spine metastases: techniques for anterior reconstruction and stabilizationThe surgical management of cervical spine metastases continues to evolve and improve. The authors provide an overview of the various techniques for anterior reconstruction and stabilization of the subaxial cervical spine after corpectomy for spinal metastases. Vertebral body reconstruction can be ac...2012-01-01
22 Blumenthal, Donald K.Effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding.Using site-directed mutagenesis we have expressed in Escherichia coli three engineered calmodulins (CaM) containing deletions in the solvent-exposed region of the central helix. These are CaM delta 84, Glu-84 removed; CaM delta 83-84, Glu-83 and Glu-84 removed; and CaM delta 81-84, Ser-81 through Gl...Drug Effects; Genetics; Metabolism1989-05-15
23 Mitchell, Joyce A.Evaluating the informatics for integrating biology and the bedside system for clinical researchBackground: Selecting patient cohorts is a critical, iterative, and often time-consuming aspect of studies involving human subjects; informatics tools for helping streamline the process have been identified as important infrastructure components for enabling clinical and translational research. We d...2009-01-01
24 Warner, Homer R.A Computer Based Information System for Patient CareBiomedical Informatics1972
25 Couldwell, William T.Expanding neurosurgeryThe history of medicine is replete with innovations in neurosurgery that have spurred further developments across the medical spectrum. Surgeons treating pathologies in the head and spine have broken ground with new approaches, techniques, and technologies since ancient times. Neurosurgeons occupy a...2014-01-01
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